The role of ubiquitin-specific peptidases in cancer progression MJ Young, KC Hsu, TE Lin, WC Chang, JJ Hung Journal of Biomedical Science 26, 1-14, 2019 | 135 | 2019 |
5-Aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating Alzheimer’s disease phenotypes HY Lee, SJ Fan, FI Huang, HY Chao, KC Hsu, TE Lin, TK Yeh, MJ Lai, ... Journal of Medicinal Chemistry 61 (16), 7087-7102, 2018 | 68 | 2018 |
Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach KC Hsu, CY Liu, TE Lin, JH Hsieh, TY Sung, HJ Tseng, JM Yang, ... Scientific Reports 7 (1), 3228, 2017 | 51 | 2017 |
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase MJ Lai, R Ojha, MH Lin, YM Liu, HY Lee, TE Lin, KC Hsu, CY Chang, ... European journal of medicinal chemistry 162, 612-630, 2019 | 41 | 2019 |
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer’s disease HJ Tseng, MH Lin, YJ Shiao, YC Yang, JC Chu, CY Chen, YY Chen, ... European Journal of Medicinal Chemistry 192, 112193, 2020 | 40 | 2020 |
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors K Nepali, TY Chang, MJ Lai, KC Hsu, Y Yen, TE Lin, SB Lee, JP Liou European Journal of Medicinal Chemistry 196, 112291, 2020 | 39 | 2020 |
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo R Ojha, K Nepali, CH Chen, KH Chuang, TY Wu, TE Lin, KC Hsu, ... European journal of medicinal chemistry 190, 112086, 2020 | 38 | 2020 |
Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for … HJ Tseng, S Banerjee, B Qian, MJ Lai, TY Wu, TI Hsu, TE Lin, KC Hsu, ... European Journal of Medicinal Chemistry 256, 115459, 2023 | 34 | 2023 |
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo YW Wu, KC Hsu, HY Lee, TC Huang, TE Lin, YL Chen, TY Sung, JP Liou, ... Frontiers in pharmacology 9, 205, 2018 | 33 | 2018 |
A novel selective JAK2 inhibitor identified using pharmacological interactions TE Lin, WC HuangFu, MW Chao, TY Sung, CD Chang, YY Chen, ... Frontiers in pharmacology 9, 1379, 2018 | 29 | 2018 |
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition A Singh, TY Chang, N Kaur, KC Hsu, Y Yen, TE Lin, MJ Lai, SB Lee, ... European Journal of Medicinal Chemistry 215, 113169, 2021 | 28 | 2021 |
13-Acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the Keap1/Nrf2/p62/SQSTM1 pathway: The need to move beyond classical … YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, ... Marine drugs 18 (8), 382, 2020 | 24 | 2020 |
Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities SW Chao, LC Chen, CC Yu, CY Liu, TE Lin, JH Guh, CY Wang, CY Chen, ... European journal of medicinal chemistry 143, 792-805, 2018 | 24 | 2018 |
Installation of pargyline, a LSD1 inhibitor, in the HDAC inhibitory template culminated in the identification of a tractable antiprostate cancer agent R Ojha, IC Chen, CM Hsieh, K Nepali, RW Lai, KC Hsu, TE Lin, SL Pan, ... Journal of Medicinal Chemistry 64 (24), 17824-17845, 2021 | 22 | 2021 |
Biological evaluation of selected flavonoids as inhibitors of MNKs targeting acute myeloid leukemia LC Chen, HL Huang, WC HuangFu, SC Yen, ST Ngo, YW Wu, TE Lin, ... Journal of Natural Products 83 (10), 2967-2975, 2020 | 20 | 2020 |
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells K Nepali, MH Lin, MW Chao, SJ Peng, KC Hsu, TE Lin, MC Chen, MJ Lai, ... Bioorganic Chemistry 91, 103119, 2019 | 19 | 2019 |
Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains KC Hsu, HC Hung, WC HuangFu, TY Sung, T Eight Lin, MY Fang, IJ Chen, ... Scientific reports 7 (1), 12336, 2017 | 19 | 2017 |
Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation MH Hsu, CY Hsieh, M Kapoor, JH Chang, HL Chu, TM Cheng, KC Hsu, ... Bioorganic Chemistry 98, 103729, 2020 | 18 | 2020 |
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma K Nepali, TI Hsu, CM Hsieh, WL Lo, MJ Lai, KC Hsu, TE Lin, JY Chuang, ... European Journal of Medicinal Chemistry 217, 113338, 2021 | 17 | 2021 |
Investigation of selected flavonoid derivatives as potent FLT3 inhibitors for the potential treatment of acute myeloid leukemia SC Yen, LC Chen, HL Huang, ST Ngo, YW Wu, TE Lin, TY Sung, ST Lien, ... Journal of Natural Products 84 (1), 1-10, 2021 | 17 | 2021 |