| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity T Maurer, LS Garrenton, A Oh, K Pitts, DJ Anderson, NJ Skelton, ... Proceedings of the National Academy of Sciences 109 (14), 5299-5304, 2012 | 694 | 2012 |
| The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression PJ Schmidt, PT Toran, AM Giannetti, PJ Bjorkman, NC Andrews Cell metabolism 7 (3), 205-214, 2008 | 434 | 2008 |
| Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis JA Di Paolo, T Huang, M Balazs, J Barbosa, KH Barck, BJ Bravo, ... Nature chemical biology 7 (1), 41-50, 2011 | 386 | 2011 |
| Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination EC Dueber, AJ Schoeffler, A Lingel, JM Elliott, AV Fedorova, AM Giannetti, ... Science 334 (6054), 376-380, 2011 | 237 | 2011 |
| Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling JR Haling, J Sudhamsu, I Yen, S Sideris, W Sandoval, W Phung, BJ Bravo, ... Cancer cell 26 (3), 402-413, 2014 | 225 | 2014 |
| Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors AM Giannetti, BD Koch, MF Browner Journal of medicinal chemistry 51 (3), 574-580, 2008 | 224 | 2008 |
| Molecular mechanism of the Syk activation switch E Tsang, AM Giannetti, D Shaw, M Dinh, KY Joyce, S Gandhi, H Ho, ... Journal of Biological Chemistry 283 (47), 32650-32659, 2008 | 188 | 2008 |
| From experimental design to validated hits: a comprehensive walk-through of fragment lead identification using surface plasmon resonance AM Giannetti Methods in enzymology 493, 169-218, 2011 | 166 | 2011 |
| HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface AM Giannetti, PJ Björkman Journal of Biological Chemistry 279 (24), 25866-25875, 2004 | 165 | 2004 |
| Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites AP West Jr, AM Giannetti, AB Herr, MJ Bennett, JS Nangiana, JR Pierce, ... Journal of molecular biology 313 (2), 385-397, 2001 | 165 | 2001 |
| Selection and characterization of replicon variants dually resistant to thumb-and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus S Le Pogam, H Kang, SF Harris, V Leveque, AM Giannetti, S Ali, ... Journal of virology 80 (12), 6146-6154, 2006 | 151 | 2006 |
| Mechanism for multiple ligand recognition by the human transferrin receptor AM Giannetti, PM Snow, O Zak, PJ Björkman PLoS biology 1 (3), e51, 2003 | 141 | 2003 |
| Docking for fragment inhibitors of AmpC β-lactamase DG Teotico, K Babaoglu, GJ Rocklin, RS Ferreira, AM Giannetti, ... Proceedings of the National Academy of Sciences 106 (18), 7455-7460, 2009 | 136 | 2009 |
| Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology GA Papalia, S Leavitt, MA Bynum, PS Katsamba, R Wilton, H Qiu, ... Analytical biochemistry 359 (1), 94-105, 2006 | 136 | 2006 |
| A global benchmark study using affinity-based biosensors RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ... Analytical biochemistry 386 (2), 194-216, 2009 | 124 | 2009 |
| Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus JQ Hang, Y Yang, SF Harris, V Leveque, HJ Whittington, S Rajyaguru, ... Journal of Biological Chemistry 284 (23), 15517-15529, 2009 | 122 | 2009 |
| Identification of substituted 2-thio-6-oxo-1, 6-dihydropyrimidines as inhibitors of human lactate dehydrogenase PS Dragovich, BP Fauber, LB Corson, CZ Ding, C Eigenbrot, HX Ge, ... Bioorganic & medicinal chemistry letters 23 (11), 3186-3194, 2013 | 96 | 2013 |
| Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors SS Antonysamy, B Aubol, J Blaney, MF Browner, AM Giannetti, SF Harris, ... Bioorganic & medicinal chemistry letters 18 (9), 2990-2995, 2008 | 82 | 2008 |
| Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase BP Fauber, PS Dragovich, J Chen, LB Corson, CZ Ding, C Eigenbrot, ... Bioorganic & medicinal chemistry letters 23 (20), 5533-5539, 2013 | 70 | 2013 |
| Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449) AM Giannetti, H Wong, GJP Dijkgraaf, EC Dueber, DF Ortwine, BJ Bravo, ... Journal of medicinal chemistry 54 (8), 2592-2601, 2011 | 67 | 2011 |
