| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase TF Franke, SI Yang, TO Chan, K Datta, A Kazlauskas, DK Morrison, ... Cell 81 (5), 727-736, 1995 | 2617 | 1995 |
| AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation TO Chan, SE Rittenhouse, PN Tsichlis Annual review of biochemistry 68 (1), 965-1014, 1999 | 1292 | 1999 |
| Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway T Skorski, A Bellacosa, M Nieborowska‐Skorska, M Majewski, R Martinez, ... The EMBO journal, 1997 | 817 | 1997 |
| Akt activation by growth factors is a multiple-step process: the role of the PH domain A Bellacosa, TO Chan, NN Ahmed, K Datta, S Malstrom, D Stokoe, ... Oncogene 17 (3), 313-325, 1998 | 742 | 1998 |
| Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase NN Ahmed, HL Grimes, A Bellacosa, TO Chan, PN Tsichlis Proceedings of the National Academy of Sciences 94 (8), 3627-3632, 1997 | 665 | 1997 |
| Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation WG King, MD Mattaliano, TO Chan, PN Tsichlis, JS Brugge Molecular and cellular biology, 1997 | 567 | 1997 |
| Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS K Datta, A Bellacosa, TO Chan, PN Tsichlis Journal of Biological Chemistry 271 (48), 30835-30839, 1996 | 389 | 1996 |
| The Gfi-1 Proto-Oncoprotein Contains a Novel Transcriptional Repressor Domain, SNAG, and Inhibits G1 Arrest Induced by Interleukin-2 Withdrawal HL Grimes, TO Chan, PA Zweidler-McKay, B Tong, PN Tsichlis Molecular and cellular biology 16 (11), 6263-6272, 1996 | 355 | 1996 |
| Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage C Kari, TO Chan, M Rocha de Quadros, U Rodeck Cancer research 63 (1), 1-5, 2003 | 242 | 2003 |
| Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation. JD Bjorge, TO Chan, M Antczak, HJ Kung, DJ Fujita Proceedings of the National Academy of Sciences 87 (10), 3816-3820, 1990 | 234 | 1990 |
| AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation K Datta, TF Franke, TO Chan, A Makris, SI Yang, DR Kaplan, DK Morrison, ... Molecular and cellular biology 15 (4), 2304-2310, 1995 | 231 | 1995 |
| The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells D Alvarez-Guardia, X Palomer, T Coll, MM Davidson, TO Chan, ... Cardiovascular research 87 (3), 449-458, 2010 | 226 | 2010 |
| TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model X Palomer, D Álvarez-Guardia, R Rodríguez-Calvo, T Coll, JC Laguna, ... Cardiovascular research 81 (4), 703-712, 2009 | 201 | 2009 |
| Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-α–induced cardiomyopathy Y Higuchi, CF McTiernan, CB Frye, BS McGowan, TO Chan, AM Feldman Circulation 109 (15), 1892-1897, 2004 | 194 | 2004 |
| Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit TO Chan, U Rodeck, AM Chan, AC Kimmelman, SE Rittenhouse, ... Cancer cell 1 (2), 181-191, 2002 | 178 | 2002 |
| PDK2: a complex tail in one Akt TO Chan, PN Tsichlis Science's STKE 2001 (66), pe1-pe1, 2001 | 166 | 2001 |
| The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death HL Grimes, CB Gilks, TO Chan, S Porter, PN Tsichlis Proceedings of the National Academy of Sciences 93 (25), 14569-14573, 1996 | 149 | 1996 |
| Regulated Overexpression of the A1-Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function H Funakoshi, TO Chan, JC Good, JR Libonati, J Piuhola, X Chen, ... Circulation 114 (21), 2240-2250, 2006 | 105* | 2006 |
| Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival M Osada, T Tolkacheva, W Li, TO Chan, PN Tsichlis, R Saez, ... Molecular and cellular biology, 1999 | 97 | 1999 |
| Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity TO Chan, J Zhang, U Rodeck, JM Pascal, RS Armen, M Spring, ... Proceedings of the National Academy of Sciences 108 (46), E1120-E1127, 2011 | 86 | 2011 |
