| Neurons respond directly to mechanical deformation with pannexin‐mediated ATP release and autostimulation of P2X7 receptors J Xia, JC Lim, W Lu, JM Beckel, EJ Macarak, AM Laties, CH Mitchell The Journal of physiology 590 (10), 2285-2304, 2012 | 172 | 2012 |
| Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels D Reigada, W Lu, M Zhang, CH Mitchell Neuroscience 157 (2), 396-404, 2008 | 154 | 2008 |
| Mechanosensitive release of adenosine 5′‐triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A … JM Beckel, AJ Argall, JC Lim, J Xia, W Lu, EE Coffey, EJ Macarak, ... Glia 62 (9), 1486-1501, 2014 | 150 | 2014 |
| The P2X7 receptor primes IL-1β and the NLRP3 inflammasome in astrocytes exposed to mechanical strain F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell Frontiers in cellular neuroscience 11, 227, 2017 | 130 | 2017 |
| Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo H Hu, W Lu, M Zhang, X Zhang, AJ Argall, S Patel, GE Lee, YC Kim, ... Experimental eye research 91 (3), 425-432, 2010 | 125 | 2010 |
| Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations S Guha, EE Coffey, W Lu, JC Lim, JM Beckel, AM Laties, ... Experimental eye research 126, 68-76, 2014 | 101 | 2014 |
| Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor S Guha, GC Baltazar, EE Coffey, LA Tu, JC Lim, JM Beckel, S Patel, ... The FASEB Journal 27 (11), 4500, 2013 | 101 | 2013 |
| Identification of the A3 adenosine receptor in rat retinal ganglion cells M Zhang, MT Budak, W Lu, TS Khurana, X Zhang, AM Laties, CH Mitchell Mol vis 12, 937-948, 2006 | 74 | 2006 |
| Degradation of extracellular ATP by the retinal pigment epithelium D Reigada, W Lu, X Zhang, C Friedman, K Pendrak, A McGlinn, RA Stone, ... American Journal of Physiology-Cell Physiology 289 (3), C617-C624, 2005 | 70 | 2005 |
| The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance CH Mitchell, W Lu, H Hu, X Zhang, D Reigada, M Zhang Purinergic signalling 4, 313-321, 2008 | 64 | 2008 |
| Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye W Lu, HL Hu, J Sévigny, TG B'Ann, PL Kaufman, EC Johnson, ... Investigative Ophthalmology & Visual Science 56 (5), 3075-3083, 2015 | 60 | 2015 |
| The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells M Zhang, H Hu, X Zhang, W Lu, J Lim, T Eysteinsson, KA Jacobson, ... Neurochemistry international 56 (1), 35-41, 2010 | 59 | 2010 |
| Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells J Liu, W Lu, S Guha, GC Baltazar, EE Coffey, AM Laties, RC Rubenstein, ... American Journal of Physiology-Cell Physiology 303 (2), C160-C169, 2012 | 56 | 2012 |
| The P2X7 receptor links mechanical strain to cytokine IL‐6 up‐regulation and release in neurons and astrocytes W Lu, F Albalawi, JM Beckel, JC Lim, AM Laties, CH Mitchell Journal of neurochemistry 141 (3), 436-448, 2017 | 55 | 2017 |
| Neuronal release of cytokine IL-3 triggered by mechanosensitive autostimulation of the P2X7 receptor is neuroprotective JC Lim, W Lu, JM Beckel, CH Mitchell Frontiers in cellular neuroscience 10, 228437, 2016 | 54 | 2016 |
| Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation NM Gómez, W Lu, JC Lim, K Kiselyov, KE Campagno, Y Grishchuk, ... The FASEB Journal 32 (2), 782, 2018 | 51 | 2018 |
| Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris S Guha, GC Baltazar, LA Tu, J Liu, JC Lim, W Lu, A Argall, ... Journal of neurochemistry 122 (4), 823-833, 2012 | 49 | 2012 |
| Glutamate acts at NMDA receptors on fresh bovine and on cultured human retinal pigment epithelial cells to trigger release of ATP D Reigada, W Lu, CH Mitchell The Journal of physiology 575 (3), 707-720, 2006 | 49 | 2006 |
| Inhibition of swelling-activated Cl− currents by functional anti-ClC-3 antibody in native bovine non-pigmented ciliary epithelial cells CW Do, W Lu, CH Mitchell, MM Civan Investigative ophthalmology & visual science 46 (3), 948-955, 2005 | 40 | 2005 |
| Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels JM Beckel, NM Gómez, W Lu, KE Campagno, B Nabet, F Albalawi, JC Lim, ... Scientific Reports 8 (1), 5726, 2018 | 39 | 2018 |
