| Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl Cell 90 (1), 65-75, 1997 | 1643 | 1997 |
| Structure and mechanism of the Hsp90 molecular chaperone machinery LH Pearl, C Prodromou Annu. Rev. Biochem. 75 (1), 271-294, 2006 | 1367 | 2006 |
| Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl Journal of medicinal chemistry 42 (2), 260-266, 1999 | 1239 | 1999 |
| Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex MMU Ali, SM Roe, CK Vaughan, P Meyer, B Panaretou, PW Piper, ... Nature 440 (7087), 1013-1017, 2006 | 1158 | 2006 |
| ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ... The EMBO journal 17 (16), 4829-4836, 1998 | 929 | 1998 |
| Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1 B Panaretou, G Siligardi, P Meyer, A Maloney, JK Sullivan, S Singh, ... Molecular cell 10 (6), 1307-1318, 2002 | 652 | 2002 |
| The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N‐terminal domains C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ... The EMBO journal, 2000 | 646 | 2000 |
| Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions P Meyer, C Prodromou, B Hu, C Vaughan, SM Roe, B Panaretou, ... Molecular cell 11 (3), 647-658, 2003 | 603 | 2003 |
| Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ... The EMBO journal, 1999 | 555 | 1999 |
| The Hsp90 molecular chaperone: an open and shut case for treatment LH Pearl, C Prodromou, P Workman Biochemical Journal 410 (3), 439-453, 2008 | 544 | 2008 |
| NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ... Cancer research 68 (8), 2850-2860, 2008 | 543 | 2008 |
| 4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ... Journal of medicinal chemistry 51 (2), 196-218, 2008 | 507 | 2008 |
| Chaperoned ubiquitylation—crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex M Zhang, M Windheim, SM Roe, M Peggie, P Cohen, C Prodromou, ... Molecular cell 20 (4), 525-538, 2005 | 461 | 2005 |
| Structure and in vivo function of Hsp90 LH Pearl, C Prodromou Current opinion in structural biology 10 (1), 46-51, 2000 | 447 | 2000 |
| The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50cdc37 SM Roe, MMU Ali, P Meyer, CK Vaughan, B Panaretou, PW Piper, ... Cell 116 (1), 87-98, 2004 | 423 | 2004 |
| Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery P Meyer The EMBO journal 23 (6), 1402-1410, 2004 | 403 | 2004 |
| Recursive PCR: a novel technique for total gene synthesis C Prodromou, LH Pearl Protein Engineering, Design and Selection 5 (8), 827-829, 1992 | 383 | 1992 |
| Structure and functional relationships of Hsp90 C Prodromou, LH Pearl Current cancer drug targets 3 (5), 301-323, 2003 | 360 | 2003 |
| Structure of an hsp90-cdc37-cdk4 complex CK Vaughan, U Gohlke, F Sobott, VM Good, MMU Ali, C Prodromou, ... Molecular cell 23 (5), 697-707, 2006 | 359 | 2006 |
| Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37 G Siligardi, B Panaretou, P Meyer, S Singh, DN Woolfson, PW Piper, ... Journal of biological chemistry 277 (23), 20151-20159, 2002 | 343 | 2002 |
Laurence PearlProfessor of Structural Biology, University of Sussex在 sussex.ac.uk 的电子邮件经过验证
