Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage AC Komor, YB Kim, MS Packer, JA Zuris, DR Liu Nature 533 (7603), 420-424, 2016 | 4907 | 2016 |
Programmable base editing of A• T to G• C in genomic DNA without DNA cleavage NM Gaudelli, AC Komor, HA Rees, MS Packer, AH Badran, DI Bryson, ... Nature 551 (7681), 464-471, 2017 | 3656 | 2017 |
CRISPR-based technologies for the manipulation of eukaryotic genomes AC Komor, AH Badran, DR Liu Cell 168 (1), 20-36, 2017 | 1231 | 2017 |
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions YB Kim, AC Komor, JM Levy, MS Packer, KT Zhao, DR Liu Nature biotechnology 35 (4), 371-376, 2017 | 830 | 2017 |
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity AC Komor, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, ... Science advances 3 (8), eaao4774, 2017 | 781 | 2017 |
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery HA Rees, AC Komor, WH Yeh, J Caetano-Lopes, M Warman, ASB Edge, ... Nature communications 8 (1), 15790, 2017 | 470 | 2017 |
Global chemical effects of the microbiome include new bile-acid conjugations RA Quinn, AV Melnik, A Vrbanac, T Fu, KA Patras, MP Christy, Z Bodai, ... Nature 579 (7797), 123-129, 2020 | 391 | 2020 |
The path for metal complexes to a DNA target AC Komor, JK Barton Chemical communications 49 (35), 3617-3630, 2013 | 388 | 2013 |
Base editing: advances and therapeutic opportunities EM Porto, AC Komor, IM Slaymaker, GW Yeo Nature Reviews Drug Discovery 19 (12), 839-859, 2020 | 302 | 2020 |
Fusions of Cas9 domains and nucleic acid-editing domains DR Liu, AC Komor US Patent 11,053,481, 2021 | 146 | 2021 |
Editing the genome without double-stranded DNA breaks AC Komor, AH Badran, DR Liu ACS chemical biology 13 (2), 383-388, 2018 | 120 | 2018 |
Methods for nucleic acid editing DR Liu, AC Komor US Patent 9,840,699, 2017 | 94 | 2017 |
Methods for correcting caspase-9 point mutations DR Liu, AC Komor US Patent App. 14/326,303, 2015 | 92 | 2015 |
Methods for correcting presenilin point mutations DR Liu, AC Komor US Patent 9,068,179, 2015 | 87 | 2015 |
Methods for correcting alpha-antitrypsin point mutations DR Liu, AC Komor US Patent App. 14/326,290, 2015 | 87 | 2015 |
Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization AC Komor, CJ Schneider, AG Weidmann, JK Barton Journal of the American Chemical Society 134 (46), 19223-19233, 2012 | 86 | 2012 |
Methods for correcting pi3k point mutations DR Liu, AC Komor US Patent App. 14/326,140, 2015 | 83 | 2015 |
Methods for correcting von willebrand factor point mutations DR Liu, AC Komor US Patent App. 14/326,318, 2015 | 79 | 2015 |
Nucleobase editors and uses thereof DR Liu, AC Komor, HA Rees, Y Kim US Patent 10,167,457, 2019 | 76 | 2019 |
Cas variants for gene editing DR Liu, AC Komor US Patent 10,465,176, 2019 | 65 | 2019 |