| Mechanisms of ADC toxicity and strategies to increase ADC tolerability TD Nguyen, BM Bordeau, JP Balthasar Cancers 15 (3), 713, 2023 | 55 | 2023 |
| Transient competitive inhibition bypasses the binding site barrier to improve tumor penetration of trastuzumab and enhance T-DM1 efficacy BM Bordeau, Y Yang, JP Balthasar Cancer research 81 (15), 4145-4154, 2021 | 34 | 2021 |
| Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor TS Owen, G Ngoje, TJ Lageman, BM Bordeau, M Belfort, BP Callahan Analytical biochemistry 488, 1-5, 2015 | 27 | 2015 |
| Strategies to enhance monoclonal antibody uptake and distribution in solid tumors BM Bordeau, JP Balthasar Cancer biology & medicine 18 (3), 649, 2021 | 21 | 2021 |
| Hedgehog proteins consume steroidal CYP17A1 antagonists: Potential therapeutic significance in advanced prostate cancer BM Bordeau, DA Ciulla, BP Callahan ChemMedChem 11 (18), 1983-1986, 2016 | 16 | 2016 |
| Payload-binding Fab fragments increase the therapeutic index of MMAE antibody–drug conjugates BM Bordeau, TD Nguyen, JR Polli, P Chen, JP Balthasar Molecular cancer therapeutics 22 (4), 459-470, 2023 | 10 | 2023 |
| Development and evaluation of competitive inhibitors of trastuzumab-HER2 binding to bypass the binding-site barrier BM Bordeau, L Abuqayyas, TD Nguyen, P Chen, JP Balthasar Frontiers in pharmacology 13, 837744, 2022 | 9 | 2022 |
| Transient inhibition of trastuzumab–tumor binding to overcome the “binding-site barrier” and improve the efficacy of a trastuzumab–gelonin immunotoxin P Chen, BM Bordeau, Y Zhang, JP Balthasar Molecular cancer therapeutics 21 (10), 1573-1582, 2022 | 5 | 2022 |
| Targeted delivery of endosomal escape peptides to enhance immunotoxin potency and anti-cancer efficacy JR Polli, P Chen, BM Bordeau, JP Balthasar The AAPS journal 24 (3), 47, 2022 | 5 | 2022 |
| Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid–Antibody–Drug Conjugates TD Nguyen, BM Bordeau, JP Balthasar Molecular cancer therapeutics 22 (11), 1332-1342, 2023 | 3 | 2023 |
| Half-life extension and biodistribution modulation of biotherapeutics via red blood cell hitch-hiking with novel anti-band 3 single-domain antibodies TD Nguyen, BM Bordeau, Y Zhang, AG Mattle, JP Balthasar International Journal of Molecular Sciences 24 (1), 475, 2022 | 3 | 2022 |
| Dynamic contrast-enhanced magnetic resonance imaging for the prediction of monoclonal antibody Tumor Disposition BM Bordeau, JR Polli, F Schweser, HP Grimm, WF Richter, JP Balthasar International Journal of Molecular Sciences 23 (2), 679, 2022 | 2 | 2022 |
| Increasing the therapeutic index of ADCs with payload binding selectivity enhancers B Bordeau Drug Metabolism and Pharmacokinetics 55, 100586, 2024 | | 2024 |
| Compositions and methods for reducing off-target toxicity of antibody drug conjugates JP Balthasar, BM Bordeau, TD Nguyen, JR Polli US Patent App. 17/782,549, 2023 | | 2023 |
| Targeted delivery of tumor matrix modifying enzymes JP Balthasar, BM Bordeau US Patent App. 17/638,725, 2022 | | 2022 |
| Compositions and methods for improving tumor penetration of tumor specific antibodies JP Balthasar, BM Bordeau US Patent App. 17/640,760, 2022 | | 2022 |
