Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer U Sahin, E Derhovanessian, M Miller, BP Kloke, P Simon, M Löwer, ... Nature 547 (7662), 222-226, 2017 | 2236 | 2017 |
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy LM Kranz, M Diken, H Haas, S Kreiter, C Loquai, KC Reuter, M Meng, ... Nature 534 (7607), 396-401, 2016 | 1546 | 2016 |
Mutant MHC class II epitopes drive therapeutic immune responses to cancer S Kreiter, M Vormehr, N Van de Roemer, M Diken, M Löwer, J Diekmann, ... Nature 520 (7549), 692-696, 2015 | 1303 | 2015 |
Exploiting the mutanome for tumor vaccination JC Castle, S Kreiter, J Diekmann, M Löwer, N Van de Roemer, J de Graaf, ... Cancer research 72 (5), 1081-1091, 2012 | 939 | 2012 |
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma U Sahin, P Oehm, E Derhovanessian, RA Jabulowsky, M Vormehr, ... Nature 585 (7823), 107-112, 2020 | 662 | 2020 |
Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity S Kreiter, A Selmi, M Diken, M Koslowski, CM Britten, C Huber, Ö Türeci, ... Cancer research 70 (22), 9031-9040, 2010 | 402 | 2010 |
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma JC Castle, M Loewer, S Boegel, J de Graaf, C Bender, AD Tadmor, ... BMC genomics 15, 1-12, 2014 | 386 | 2014 |
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors K Reinhard, B Rengstl, P Oehm, K Michel, A Billmeier, N Hayduk, O Klein, ... Science 367 (6476), 446-453, 2020 | 345 | 2020 |
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis C Krienke, L Kolb, E Diken, M Streuber, S Kirchhoff, T Bukur, ... Science 371 (6525), 145-153, 2021 | 319 | 2021 |
HLA typing from RNA-Seq sequence reads S Boegel, M Löwer, M Schäfer, T Bukur, J De Graaf, V Boisguérin, ... Genome medicine 4, 1-12, 2013 | 300 | 2013 |
Improving mRNA-based therapeutic gene delivery by expression-augmenting 3′ UTRs identified by cellular library screening AGO von Niessen, MA Poleganov, C Rechner, A Plaschke, LM Kranz, ... Molecular Therapy 27 (4), 824-836, 2019 | 278 | 2019 |
Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo AN Kuhn, M Diken, S Kreiter, A Selmi, J Kowalska, J Jemielity, ... Gene therapy 17 (8), 961-971, 2010 | 257 | 2010 |
Tumor vaccination using messenger RNA: prospects of a future therapy S Kreiter, M Diken, A Selmi, Ö Türeci, U Sahin Current opinion in immunology 23 (3), 399-406, 2011 | 231 | 2011 |
Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation M Diken, S Kreiter, A Selmi, CM Britten, C Huber, Ö Türeci, U Sahin Gene therapy 18 (7), 702-708, 2011 | 204 | 2011 |
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals S Kreiter, A Selmi, M Diken, M Sebastian, P Osterloh, H Schild, C Huber, ... The Journal of Immunology 180 (1), 309-318, 2008 | 189 | 2008 |
Individualized vaccines for cancer U Sahin, S Kreiter, M Diken, J Diekmann, M Koslowski, C Britten, ... US Patent 10,738,355, 2020 | 178 | 2020 |
Targeting the heterogeneity of cancer with individualized neoepitope vaccines Ö Türeci, M Vormehr, M Diken, S Kreiter, C Huber, U Sahin Clinical Cancer Research 22 (8), 1885-1896, 2016 | 160 | 2016 |
Polymeric nanoparticles with neglectable protein corona I Alberg, S Kramer, M Schinnerer, Q Hu, C Seidl, C Leps, N Drude, ... Small 16 (18), 1907574, 2020 | 137 | 2020 |
Nanomedicine and macroscale materials in immuno-oncology Q Sun, M Barz, BG De Geest, M Diken, WE Hennink, F Kiessling, ... Chemical Society Reviews 48 (1), 351-381, 2019 | 133 | 2019 |
Specific hepatic delivery of procollagen α1 (I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis C Jiménez Calvente, A Sehgal, Y Popov, YO Kim, V Zevallos, U Sahin, ... Hepatology 62 (4), 1285-1297, 2015 | 123 | 2015 |