| Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non–small cell lung cancer RC Doebele, AB Pilling, DL Aisner, TG Kutateladze, AT Le, AJ Weickhardt, ... Clinical cancer research 18 (5), 1472-1482, 2012 | 1280 | 2012 |
| Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein S Pugazhenthi, A Nesterova, C Sable, KA Heidenreich, LM Boxer, ... Journal of Biological Chemistry 275 (15), 10761-10766, 2000 | 974 | 2000 |
| Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. RA Nemenoff, S Winitz, NX Qian, V Van Putten, GL Johnson, LE Heasley Journal of Biological Chemistry 268 (3), 1960-1964, 1993 | 627 | 1993 |
| Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells L Marek, KE Ware, A Fritzsche, P Hercule, WR Helton, JE Smith, ... Molecular pharmacology 75 (1), 196-207, 2009 | 279 | 2009 |
| Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines AF Soriano, B Helfrich, DC Chan, LE Heasley, PA Bunn Jr, TC Chou Cancer Research 59 (24), 6178-6184, 1999 | 275 | 1999 |
| MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. SK Gupta, C Gallego, GL Johnson, LE Heasley Journal of Biological Chemistry 267 (12), 7987-7990, 1992 | 272 | 1992 |
| A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop KE Ware, TK Hinz, E Kleczko, KR Singleton, LA Marek, BA Helfrich, ... Oncogenesis 2 (3), e39-e39, 2013 | 254 | 2013 |
| Autocrine and paracrine signaling through neuropeptide receptors in human cancer LE Heasley Oncogene 20 (13), 1563-1569, 2001 | 253 | 2001 |
| G protein-coupled receptor systems involved in cell growth and oncogenesis N Dhanasekaran, LE Heasley, GL Johnson Endocrine reviews 16 (3), 259-270, 1995 | 247 | 1995 |
| Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of Gα12 and Gα13 MV Prasad, JM Dermott, LE Heasley, GL Johnson, N Dhanasekaran Journal of Biological Chemistry 270 (31), 18655-18659, 1995 | 236 | 1995 |
| Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells LE Heasley, GL Johnson Journal of Biological Chemistry 264 (15), 8646-8652, 1989 | 229 | 1989 |
| Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration A Oweida, MK Hararah, A Phan, D Binder, S Bhatia, S Lennon, ... Clinical Cancer Research 24 (21), 5368-5380, 2018 | 225 | 2018 |
| Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer RMA Linger, RA Cohen, CT Cummings, S Sather, J Migdall-Wilson, ... Oncogene 32 (29), 3420-3431, 2013 | 222 | 2013 |
| Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer LE Heasley, S Thaler, M Nicks, B Price, K Skorecki, RA Nemenoff Journal of Biological Chemistry 272 (23), 14501-14504, 1997 | 214 | 1997 |
| Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation RA Winn, L Marek, SY Han, K Rodriguez, N Rodriguez, M Hammond, ... Journal of Biological Chemistry 280 (20), 19625-19634, 2005 | 209 | 2005 |
| The beta-PDGF receptor induces neuronal differentiation of PC12 cells. LE Heasley, GL Johnson Molecular biology of the cell 3 (5), 545-553, 1992 | 198 | 1992 |
| Peroxisome proliferator-activated receptor-γ is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth M Wick, G Hurteau, C Dessev, D Chan, MW Geraci, RA Winn, LE Heasley, ... Molecular pharmacology 62 (5), 1207-1214, 2002 | 192 | 2002 |
| c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation L Butterfield, B Storey, L Maas, LE Heasley Journal of Biological Chemistry 272 (15), 10110-10116, 1997 | 181 | 1997 |
| Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression KE Ware, ME Marshall, LR Heasley, L Marek, TK Hinz, P Hercule, ... PloS one 5 (11), e14117, 2010 | 173 | 2010 |
| FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies MW Wynes, TK Hinz, D Gao, M Martini, LA Marek, KE Ware, MG Edwards, ... Clinical cancer research 20 (12), 3299-3309, 2014 | 163 | 2014 |
