LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer T Boulding, RD McCuaig, A Tan, K Hardy, F Wu, J Dunn, M Kalimutho, ... Scientific reports 8 (1), 73, 2018 | 152 | 2018 |
Genome-wide analysis of gene expression in T cells to identify targets of the NF-κB transcription factor c-Rel K Bunting, S Rao, K Hardy, D Woltring, GS Denyer, J Wang, S Gerondakis, ... The Journal of Immunology 178 (11), 7097-7109, 2007 | 147 | 2007 |
Transcriptional networks and cellular senescence in human mammary fibroblasts K Hardy, L Mansfield, A Mackay, S Benvenuti, S Ismail, P Arora, ... Molecular biology of the cell 16 (2), 943-953, 2005 | 107 | 2005 |
The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis G Chen, K Hardy, E Pagler, L Ma, S Lee, S Gerondakis, S Daley, ... The Journal of Immunology 187 (9), 4483-4491, 2011 | 96 | 2011 |
Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel G Chen, K Hardy, K Bunting, S Daley, L Ma, MF Shannon The Journal of Immunology 185 (4), 2350-2359, 2010 | 88 | 2010 |
Lysine-specific histone demethylase 1A regulates macrophage polarization and checkpoint molecules in the tumor microenvironment of triple-negative breast cancer AHY Tan, WJ Tu, R McCuaig, K Hardy, T Donovan, S Tsimbalyuk, ... Frontiers in Immunology 10, 1351, 2019 | 82 | 2019 |
Differential roles for DUSP family members in epithelial-to-mesenchymal transition and cancer stem cell regulation in breast cancer T Boulding, F Wu, R McCuaig, J Dunn, CR Sutton, K Hardy, W Tu, ... PloS one 11 (2), e0148065, 2016 | 64 | 2016 |
Activation and signal transduction via mitogen‐activated protein (MAP) kinases in T lymphocytes K Hardy, G Chaudhri Immunology and cell biology 75 (6), 528-545, 1997 | 62 | 1997 |
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling A Liston, K Hardy, Y Pittelkow, SR Wilson, LE Makaroff, AM Fahrer, ... Genome biology 8, 1-23, 2007 | 57 | 2007 |
Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells A Zafar, F Wu, K Hardy, J Li, WJ Tu, R McCuaig, J Harris, KK Khanna, ... Molecular and cellular biology 34 (16), 2961-2980, 2014 | 56 | 2014 |
Dichloroacetate prevents cisplatin-induced nephrotoxicity without compromising cisplatin anticancer properties R Galgamuwa, K Hardy, JE Dahlstrom, AC Blackburn, E Wium, M Rooke, ... Journal of the American Society of Nephrology 27 (11), 3331-3344, 2016 | 54 | 2016 |
Targeting nuclear LSD1 to reprogram cancer cells and reinvigorate exhausted T cells via a novel LSD1-EOMES switch WJ Tu, RD McCuaig, AHY Tan, K Hardy, N Seddiki, S Ali, JE Dahlstrom, ... Frontiers in Immunology 11, 1228, 2020 | 50 | 2020 |
Differential effects of the antioxidant α-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells RA Pack, K Hardy, MC Madigan, NH Hunt Molecular immunology 38 (10), 733-745, 2002 | 46 | 2002 |
Defining the chromatin signature of inducible genes in T cells PS Lim, K Hardy, KL Bunting, L Ma, K Peng, X Chen, MF Shannon Genome biology 10, 1-18, 2009 | 36 | 2009 |
Chromatinized protein kinase C-θ: can it escape the clutches of NF-κB? EL Sutcliffe, J Li, A Zafar, K Hardy, R Ghildyal, R McCuaig, NC Norris, ... Frontiers in immunology 3, 260, 2012 | 31 | 2012 |
Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes J Dunn, R McCuaig, WJ Tu, K Hardy, S Rao BMC immunology 16, 1-11, 2015 | 28 | 2015 |
Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway LM Grønning, R Tingsabadh, K Hardy, KT Dalen, PS Jat, L Gnudi, ... American Journal of Physiology-Endocrinology and Metabolism 290 (4), E599-E606, 2006 | 27 | 2006 |
Identification of chromatin accessibility domains in human breast cancer stem cells K Hardy, F Wu, W Tu, A Zafar, T Boulding, R McCuaig, CR Sutton, ... Nucleus 7 (1), 50-67, 2016 | 26 | 2016 |
KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation J Li, K Hardy, M Olshansky, A Barugahare, LJ Gearing, JE Prier, XYX Sng, ... Cell reports 34 (11), 2021 | 25 | 2021 |
Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells WJ Tu, K Hardy, CR Sutton, R McCuaig, J Li, J Dunn, A Tan, V Brezar, ... Scientific reports 7 (1), 44825, 2017 | 25 | 2017 |