Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions M Salwiczek, EK Nyakatura, UIM Gerling, S Ye, B Koksch Chemical Society Reviews 41 (6), 2135-2171, 2012 | 468 | 2012 |
Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses AZ Wec, AS Herbert, CD Murin, EK Nyakatura, DM Abelson, JM Fels, ... Cell 169 (5), 878-890. e15, 2017 | 158 | 2017 |
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses AZ Wec, EK Nyakatura, AS Herbert, KA Howell, FW Holtsberg, RR Bakken, ... Science 354 (6310), 350-354, 2016 | 128 | 2016 |
Protocadherin-1 is essential for cell entry by New World hantaviruses RK Jangra, AS Herbert, R Li, LT Jae, LM Kleinfelter, MM Slough, ... Nature 563 (7732), 559-563, 2018 | 114 | 2018 |
Pan-ebolavirus and pan-filovirus mouse monoclonal antibodies: protection against Ebola and Sudan viruses FW Holtsberg, S Shulenin, H Vu, KA Howell, SJ Patel, B Gunn, M Karim, ... Journal of virology 90 (1), 266-278, 2016 | 105 | 2016 |
Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein L Vozzolo, B Loh, PJ Gane, M Tribak, L Zhou, I Anderson, E Nyakatura, ... Journal of Biological Chemistry 285 (50), 39314-39328, 2010 | 96 | 2010 |
Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site KA Howell, X Qiu, JM Brannan, C Bryan, E Davidson, FW Holtsberg, ... Cell reports 15 (7), 1514-1526, 2016 | 89 | 2016 |
Position‐Dependent Effects of Fluorinated Amino Acids on the Hydrophobic Core Formation of a Heterodimeric Coiled Coil M Salwiczek, S Samsonov, T Vagt, E Nyakatura, E Fleige, J Numata, ... Chemistry–A European Journal 15 (31), 7628-7636, 2009 | 58 | 2009 |
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever JM Fels, DP Maurer, AS Herbert, AS Wirchnianski, O Vergnolle, RW Cross, ... Cell 184 (13), 3486-3501. e21, 2021 | 55 | 2021 |
Chemical and structural aspects of Ebola virus entry inhibitors EK Nyakatura, JC Frei, JR Lai ACS infectious diseases 1 (1), 42-52, 2015 | 45 | 2015 |
Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins JA Quiroz, RJ Malonis, LB Thackray, CA Cohen, J Pallesen, RK Jangra, ... PLoS pathogens 15 (11), e1008061, 2019 | 41 | 2019 |
Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses JC Frei, EK Nyakatura, SE Zak, RR Bakken, K Chandran, JM Dye, JR Lai Scientific reports 6 (1), 19193, 2016 | 39 | 2016 |
Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide T Vagt, E Nyakatura, M Salwiczek, C Jäckel, B Koksch Organic & biomolecular chemistry 8 (6), 1382-1386, 2010 | 33 | 2010 |
Bispecific antibodies for viral immunotherapy EK Nyakatura, AY Soare, JR Lai Human vaccines & immunotherapeutics 13 (4), 836-842, 2017 | 27 | 2017 |
Accommodating fluorinated amino acids in a helical peptide environment EK Nyakatura, O Reimann, T Vagt, M Salwiczek, B Koksch RSC advances 3 (18), 6319-6322, 2013 | 27 | 2013 |
Synthesis of enantiomerically pure (2S, 3S)-5, 5, 5-trifluoroisoleucine and (2R, 3S)-5, 5, 5-trifluoro-allo-isoleucine H Erdbrink, EK Nyakatura, S Huhmann, UIM Gerling, D Lentz, B Koksch, ... Beilstein Journal of Organic Chemistry 9 (1), 2009-2014, 2013 | 25 | 2013 |
Effects of single substitutions with hexafluoroleucine and trifluorovaline on the hydrophobic core formation of a heterodimeric coiled coil S Huhmann, EK Nyakatura, H Erdbrink, UIM Gerling, C Czekelius, ... Journal of Fluorine Chemistry 175, 32-35, 2015 | 24 | 2015 |
Design and evaluation of bi-and trispecific antibodies targeting multiple filovirus glycoproteins EK Nyakatura, SE Zak, AZ Wec, D Hofmann, S Shulenin, RR Bakken, ... Journal of Biological Chemistry 293 (16), 6201-6211, 2018 | 14 | 2018 |
An Unusual Interstrand H-Bond Stabilizes the Heteroassembly of Helical αβγ-Chimeras with Natural Peptides EK Nyakatura, R Rezaei Araghi, J Mortier, S Wieczorek, C Baldauf, ... ACS Chemical Biology 9 (3), 613-616, 2014 | 13 | 2014 |
A TCR mimic monoclonal antibody reactive with the “public” phospho-neoantigen pIRS2/HLA-A* 02: 01 complex T Dao, SS Mun, Z Molvi, T Korontsvit, MG Klatt, AG Khan, EK Nyakatura, ... JCI insight 7 (5), 2022 | 10 | 2022 |