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Mariëtte van der Watt
Mariëtte van der Watt
在 up.ac.za 的电子邮件经过验证
标题
引用次数
引用次数
年份
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ...
Science translational medicine 9 (387), 2017
2522017
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
J Reader, M Botha, A Theron, SB Lauterbach, C Rossouw, D Engelbrecht, ...
Malaria journal 14 (1), 1-17, 2015
1262015
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ...
Nature communications 12 (1), 1-15, 2021
732021
UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria
C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ...
Antimicrobial agents and chemotherapy 62 (9), e00012-18, 2018
662018
Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites
N Coetzee, H von Grüning, D Opperman, M van der Watt, J Reader, ...
Scientific reports 10 (1), 1-11, 2020
612020
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in …
K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ...
Journal of medicinal chemistry 60 (4), 1432-1448, 2017
552017
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle
C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ...
Journal of medicinal chemistry 59 (21), 9890-9905, 2016
502016
Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte stages
D Coertzen, J Reader, M Van Der Watt, SH Nondaba, L Gibhard, ...
Antimicrobial agents and chemotherapy 62 (8), e02214-17, 2018
432018
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
RM Beteck, R Seldon, D Coertzen, ME Van Der Watt, J Reader, ...
Communications Chemistry 1 (1), 1-11, 2018
342018
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship …
C Le Manach, T Paquet, C Brunschwig, M Njoroge, Z Han, ...
Journal of medicinal chemistry 58 (21), 8713-8722, 2015
322015
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites
M Leshabane, GA Dziwornu, D Coertzen, J Reader, P Moyo, ...
ACS Infectious Diseases, 2021
272021
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials
ME van der Watt, J Reader, A Churchyard, SH Nondaba, SB Lauterbach, ...
Journal of Antimicrobial Chemotherapy 73 (5), 1279-1290, 2018
242018
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo …
GA Dziwornu, D Coertzen, M Leshabane, CM Korkor, CK Cloete, ...
Journal of Medicinal Chemistry 64 (8), 5198-5215, 2021
232021
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products
P Moyo, W Shamburger, ME van der Watt, J Reader, ACC De Sousa, ...
International Journal for Parasitology: Drugs and Drug Resistance 13, 51-58, 2020
202020
Identification and profiling of a novel diazaspiro [3.4] octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and …
C Le Manach, J Dam, JG Woodland, G Kaur, LP Khonde, C Brunschwig, ...
Journal of Medicinal Chemistry 64 (4), 2291-2309, 2021
192021
Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action
M Kumar, J Okombo, D Mambwe, D Taylor, N Lawrence, J Reader, ...
ACS infectious diseases 5 (2), 303-315, 2018
192018
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum including …
HN Wong, V Padín-Irizarry, ME van der Watt, J Reader, W Liebenberg, ...
Frontiers in chemistry 7, 901, 2020
172020
Activities of 11‐azaartemisinin and N‐sulfonyl derivatives against asexual and transmissible malaria parasites
R Harmse, D Coertzen, HN Wong, FJ Smit, ME Van der Watt, J Reader, ...
Wiley, 2017
162017
A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail
PB Burger, M Williams, J Sprenger, SB Reeksting, M Botha, IB Müller, ...
Malaria journal 14 (1), 1-18, 2015
152015
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and …
PM Cheuka, L Centani, LB Arendse, S Fienberg, L Wambua, SS Renga, ...
ACS Infectious Diseases 7 (1), 34-46, 2020
142020
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