Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions DG Lupiáñez, K Kraft, V Heinrich, P Krawitz, F Brancati, E Klopocki, ... Cell 161 (5), 1012-1025, 2015 | 2121 | 2015 |
Enhancer redundancy provides phenotypic robustness in mammalian development M Osterwalder, I Barozzi, V Tissières, Y Fukuda-Yuzawa, BJ Mannion, ... Nature 554 (7691), 239-243, 2018 | 604 | 2018 |
Progressive loss of function in a limb enhancer during snake evolution EZ Kvon, OK Kamneva, US Melo, I Barozzi, M Osterwalder, BJ Mannion, ... Cell 167 (3), 633-642. e11, 2016 | 333 | 2016 |
Ultraconserved enhancers are required for normal development DE Dickel, AR Ypsilanti, R Pla, Y Zhu, I Barozzi, BJ Mannion, YS Khin, ... Cell 172 (3), 491-499. e15, 2018 | 194 | 2018 |
Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development A Galli, D Robay, M Osterwalder, X Bao, JD Bénazet, M Tariq, R Paro, ... PLoS genetics 6 (4), e1000901, 2010 | 175 | 2010 |
Loss of extreme long-range enhancers in human neural crest drives a craniofacial disorder HK Long, M Osterwalder, IC Welsh, K Hansen, JOJ Davies, YE Liu, ... Cell Stem Cell 27 (5), 765-783. e14, 2020 | 123 | 2020 |
HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme M Osterwalder, D Speziale, M Shoukry, R Mohan, R Ivanek, M Kohler, ... Developmental cell 31 (3), 345-357, 2014 | 123 | 2014 |
Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog) AJ Will, G Cova, M Osterwalder, WL Chan, L Wittler, N Brieske, V Heinrich, ... Nature genetics 49 (10), 1539-1545, 2017 | 120 | 2017 |
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis J Lopez-Rios, D Speziale, D Robay, M Scotti, M Osterwalder, ... Developmental cell 22 (4), 837-848, 2012 | 114 | 2012 |
Genome-wide compendium and functional assessment of in vivo heart enhancers DE Dickel, I Barozzi, Y Zhu, Y Fukuda-Yuzawa, M Osterwalder, ... Nature communications 7 (1), 12923, 2016 | 102 | 2016 |
Cardiac reprogramming factors synergistically activate genome-wide cardiogenic stage-specific enhancers H Hashimoto, Z Wang, GA Garry, VS Malladi, GA Botten, W Ye, H Zhou, ... Cell stem cell 25 (1), 69-86. e5, 2019 | 90 | 2019 |
Dual RMCE for efficient re-engineering of mouse mutant alleles M Osterwalder, A Galli, B Rosen, WC Skarnes, R Zeller, J Lopez-Rios Nature methods 7 (11), 893-895, 2010 | 87 | 2010 |
Distal limb patterning requires modulation of cis-regulatory activities by HOX13 R Sheth, I Barozzi, D Langlais, M Osterwalder, S Nemec, HL Carlson, ... Cell reports 17 (11), 2913-2926, 2016 | 76 | 2016 |
Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli, M Osterwalder, ... Cell reports 9 (6), 2071-2083, 2014 | 71 | 2014 |
Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos J Itou, H Kawakami, T Quach, M Osterwalder, SM Evans, R Zeller, ... Development 139 (9), 1620-1629, 2012 | 65 | 2012 |
HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development F Laurent, A Girdziusaite, J Gamart, I Barozzi, M Osterwalder, JA Akiyama, ... Cell reports 19 (8), 1602-1613, 2017 | 63 | 2017 |
The mole genome reveals regulatory rearrangements associated with adaptive intersexuality F M. Real, SA Haas, P Franchini, P Xiong, O Simakov, H Kuhl, R Schöpflin, ... Science 370 (6513), 208-214, 2020 | 49 | 2020 |
Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors S Kult, T Olender, M Osterwalder, S Markman, D Leshkowitz, S Krief, ... Elife 10, e55361, 2021 | 40 | 2021 |
Noncoding deletions reveal a gene that is critical for intestinal function D Oz-Levi, T Olender, I Bar-Joseph, Y Zhu, D Marek-Yagel, I Barozzi, ... Nature 571 (7763), 107-111, 2019 | 29 | 2019 |
Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb R Monti, I Barozzi, M Osterwalder, E Lee, M Kato, TH Garvin, ... PLoS computational biology 13 (8), e1005720, 2017 | 23 | 2017 |