Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers N Mars, JT Koskela, P Ripatti, TTJ Kiiskinen, AS Havulinna, JV Lindbohm, ... Nature medicine 26 (4), 549-557, 2020 | 326 | 2020 |
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease W Zhou, M Kanai, KHH Wu, H Rasheed, K Tsuo, JB Hirbo, Y Wang, ... Cell Genomics 2 (10), 2022 | 198 | 2022 |
Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap H Iwamoto, J Gao, J Koskela, V Kinnula, H Kobayashi, T Laitinen, ... European Respiratory Journal 43 (2), 421-429, 2014 | 183 | 2014 |
Genetic architecture of human plasma lipidome and its link to cardiovascular disease R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, ... Nature communications 10 (1), 4329, 2019 | 141 | 2019 |
Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease GJ Walker, JW Harrison, GA Heap, MD Voskuil, V Andersen, ... Jama 321 (8), 773-785, 2019 | 139 | 2019 |
Geographic variation and bias in the polygenic scores of complex diseases and traits in Finland S Kerminen, AR Martin, J Koskela, SE Ruotsalainen, AS Havulinna, ... The American Journal of Human Genetics 104 (6), 1169-1181, 2019 | 118 | 2019 |
Sleep apnoea is a risk factor for severe COVID-19 S Strausz, T Kiiskinen, M Broberg, S Ruotsalainen, J Koskela, A Bachour, ... BMJ Open Respiratory Research 8 (1), e000845, 2021 | 116 | 2021 |
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population MA Rivas, BE Avila, J Koskela, H Huang, C Stevens, M Pirinen, ... PLoS genetics 14 (5), e1007329, 2018 | 94 | 2018 |
Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD J Koskela, M Kilpeläinen, H Kupiainen, W Mazur, H Sintonen, M Boezen, ... BMC pulmonary medicine 14, 1-11, 2014 | 92 | 2014 |
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility A Sazonovs, CR Stevens, GR Venkataraman, K Yuan, B Avila, MT Abreu, ... Nature genetics 54 (9), 1275-1283, 2022 | 83 | 2022 |
Characterization of sputum biomarkers for asthma–COPD overlap syndrome J Gao, H Iwamoto, J Koskela, H Alenius, N Hattori, N Kohno, T Laitinen, ... International journal of chronic obstructive pulmonary disease, 2457-2465, 2016 | 65 | 2016 |
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts Y Wang, S Namba, E Lopera, S Kerminen, K Tsuo, K Läll, M Kanai, ... Cell Genomics 3 (1), 2023 | 53 | 2023 |
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution M Kanai, R Elzur, W Zhou, KHH Wu, H Rasheed, K Tsuo, JB Hirbo, ... Cell Genomics 2 (12), 2022 | 52 | 2022 |
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers A Palomäki, A Palotie, J Koskela, KK Eklund, M Pirinen, S Ripatti, ... Annals of the Rheumatic Diseases 80 (12), 1530-1536, 2021 | 30 | 2021 |
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics JJ Partanen, P Häppölä, W Zhou, AA Lehisto, M Ainola, E Sutinen, ... Cell genomics 2 (10), 2022 | 29 | 2022 |
Physical activity in COPD patients decreases short-acting bronchodilator use and the number of exacerbations M Katajisto, J Koskela, A Lindqvist, M Kilpeläinen, T Laitinen Respiratory medicine 109 (10), 1320-1325, 2015 | 29 | 2015 |
Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy JS Tyrmi, T Kaartokallio, AI Lokki, T Jääskeläinen, E Kortelainen, ... JAMA cardiology 8 (7), 674-683, 2023 | 28 | 2023 |
Genomic prediction of alcohol-related morbidity and mortality T Kiiskinen, NJ Mars, T Palviainen, J Koskela, JT Rämö, P Ripatti, ... Translational Psychiatry 10 (1), 23, 2020 | 28 | 2020 |
Face masks to prevent transmission of respiratory diseases: Systematic review and meta-analysis of randomized controlled trials* HM Ollila, M Partinen, J Koskela, R Savolainen, A Rotkirch, LT Laine medRxiv, 2020.07. 31.20166116, 2020 | 23 | 2020 |
Genetic associations and architecture of asthma-COPD overlap C John, AL Guyatt, N Shrine, R Packer, TA Olafsdottir, J Liu, LP Hayden, ... Chest 161 (5), 1155-1166, 2022 | 19 | 2022 |