On-demand manufacturing of clinical-quality biopharmaceuticals LE Crowell, AE Lu, KR Love, A Stockdale, SM Timmick, D Wu, Y Wang, ... Nature biotechnology 36 (10), 988-995, 2018 | 104 | 2018 |
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice NC Dalvie, SA Rodriguez-Aponte, BL Hartwell, LH Tostanoski, ... Proceedings of the National Academy of Sciences 118 (38), e2106845118, 2021 | 78 | 2021 |
Host-Informed Expression of CRISPR Guide RNA for Genomic Engineering in Komagataella phaffii NC Dalvie, J Leal, CA Whittaker, Y Yang, JR Brady, KR Love, JC Love ACS synthetic biology 9 (1), 26-35, 2019 | 50 | 2019 |
Comparative genome‐scale analysis of Pichia pastoris variants informs selection of an optimal base strain JR Brady, CA Whittaker, MC Tan, DL Kristensen, D Ma, NC Dalvie, ... Biotechnology and Bioengineering 117 (2), 543-555, 2020 | 39 | 2020 |
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters NC Dalvie, SA Rodriguez-Aponte, BL Hartwell, LH Tostanoski, ... BioRxiv, 2021 | 19 | 2021 |
Alternative hosts as the missing link for equitable therapeutic protein production JR Brady, JC Love Nature Biotechnology 39 (4), 404-407, 2021 | 18 | 2021 |
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus NC Dalvie, JR Brady, LE Crowell, MK Tracey, AM Biedermann, K Kaur, ... Microbial Cell Factories 20 (1), 94, 2021 | 16 | 2021 |
Identifying improved sites for heterologous gene integration using ATAC-seq JR Brady, MC Tan, CA Whittaker, NA Colant, NC Dalvie, KR Love, ... ACS synthetic biology 9 (9), 2515-2524, 2020 | 16 | 2020 |
Rapid developability assessments to formulate recombinant protein antigens as stable, low-cost, multi-dose vaccine candidates: Case-study with non-replicating rotavirus (NRRV … N Sawant, K Kaur, DA Holland, JM Hickey, S Agarwal, JR Brady, ... Journal of pharmaceutical sciences 110 (3), 1042-1053, 2021 | 15 | 2021 |
Mechanism of thimerosal-induced structural destabilization of a recombinant rotavirus P [4] protein antigen formulated as a multi-dose vaccine K Kaur, J Xiong, N Sawant, S Agarwal, JM Hickey, DA Holland, ... Journal of pharmaceutical sciences 110 (3), 1054-1066, 2021 | 10 | 2021 |
Stimulation-induced changes at the electrode–tissue interface and their influence on deep brain stimulation J Evers, K Sridhar, J Liegey, J Brady, H Jahns, M Lowery Journal of neural engineering 19 (4), 046004, 2022 | 8 | 2022 |
Constructs and cells for enhanced protein expression KR Love, JC Love, C Whittaker, J Brady, CB Matthews, N Colant, ... US Patent App. 16/080,844, 2020 | 1 | 2020 |
Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii Y Yang, NC Dalvie, JR Brady, C Naranjo, T Lorgeree, S Rodriguez, ... ESS Open Archive eprints 553, 55322456, 2024 | | 2024 |
Manufacturing of Aglycosylated Monoclonal Antibodies in Yeast NC Dalvie, JR Brady, C Naranjo, SR Aponte, R Johnston, JC Love 2022 AIChE Annual Meeting, 2022 | | 2022 |
Modeling of copy number variability in Pichia pastoris AE Lu, AJ Maloney, NC Dalvie, JR Brady, KR Love, JC Love, RD Braatz Biotechnology and Bioengineering 118 (5), 1832-1839, 2021 | | 2021 |
A multi-omics approach to improving productivity of therapeutic proteins in Pichia pastoris (Komagataella phaffii) JR Brady Massachusetts Institute of Technology, 2020 | | 2020 |
Engineering quality and manufacturability of a trivalent protein subunit vaccine N Dalvie, JR Brady, MK Tracey, L Crowell, DL Kristensen, KR Love, ... 2019 AIChE Annual Meeting, 2019 | | 2019 |
Optimizing heterologous gene dosage in eukaryotes informed by omic analysis of over 125 yeast strains J Brady, C Whittaker, M Tan, N Colant, K Love, J Love ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019 | | 2019 |
Leveraging-omics techniques to enhance productivity of biologics in microbes J Brady, C Whittaker, M Tang, N Colant, N Dalvie, K Love, J Love ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
Leptospirosis in two squirrel monkeys (Samiri sciureus) [Conference poster]. AM Lee, J Schoening, J Cassidy, J Bainbridge, J Brady, S Peters, ... | | 2018 |