Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis AE John, RH Graves, KT Pun, G Vitulli, EJ Forty, PF Mercer, JL Morrell, ... Nature communications 11 (1), 4659, 2020 | 83 | 2020 |
The circadian clock protein REVERBα inhibits pulmonary fibrosis development PS Cunningham, P Meijer, A Nazgiewicz, SG Anderson, LA Borthwick, ... Proceedings of the National Academy of Sciences 117 (2), 1139-1147, 2020 | 65 | 2020 |
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis J Leslie, BJM Millar, A del Carpio Pons, RA Burgoyne, JD Frost, ... JCI insight 5 (4), 2020 | 64 | 2020 |
The role of epithelial damage in the pulmonary immune response RA Burgoyne, AJ Fisher, LA Borthwick Cells 10 (10), 2763, 2021 | 59 | 2021 |
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis J Leslie, MG Macia, S Luli, JC Worrell, WJ Reilly, HL Paish, A Knox, ... Nature metabolism 2 (11), 1350-1367, 2020 | 29 | 2020 |
A mammalian target of rapamycin‐perilipin 3 (mTORC1‐Plin3) pathway is essential to activate lipophagy and protects against hepatosteatosis M Garcia‐Macia, A Santos‐Ledo, J Leslie, HL Paish, AL Collins, RS Scott, ... Hepatology 74 (6), 3441-3459, 2021 | 27 | 2021 |
Anti–Cholestatic Therapy with obeticholic acid improves short-term memory in bile duct–ligated mice LMV Gee, B Barron-Millar, J Leslie, C Richardson, MYW Zaki, S Luli, ... The American Journal of Pathology 193 (1), 11-26, 2023 | 9 | 2023 |
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease AL Wilkinson, AE John, JW Barrett, E Gower, VS Morrison, Y Man, KT Pun, ... European Journal of Pharmacology 913, 174618, 2021 | 5 | 2021 |
Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease R Younes, R Burgoyne, D Tiniakos, O Govaere Hepatoma Research 7, 2021 | 2 | 2021 |
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis P Weeratunga, B Hunter, M Sergeant, J Bull, C Clelland, L Denney, ... medRxiv, 2024.04. 10.24305440, 2024 | 1 | 2024 |
S101 Identification and validation of novel therapeutic targets in IPF using human tissue models RA Burgoyne, BS Barksby, S Murphy, L Sabater, LS Patterson, J Majo, ... Thorax 78 (Suppl 4), A73-A73, 2023 | | 2023 |
Distinct Idiopathic Pulmonary Fibrosis Associated Transcriptome and Methylome Changes in Airway and Parenchymal Fibroblasts P Rajasekar, A Lagan, J Patel, B Barksby, RA Burgoyne, JL MacIssac, ... D29. TRANSLATIONAL RESEARCH IN IPF, A6477-A6477, 2023 | | 2023 |
Differential IPF Associated Gene Expression and DNA Methylation Changes in Human Airway and Parenchymal Fibroblasts P Rajasekar, AL Lagan, J Patel, B Barksby, RA Burgoyne, J MacIsaac, ... C109. PULMONARY FIBROSIS: MOVING FORWARD WITH GENETICS AND SEQUENCING, A4977 …, 2022 | | 2022 |
The Role of the Interleukin 1 Family in Lung Disease WJ Reilly, RA Burgoyne, LA Borthwick Academic Press, 2022 | | 2022 |
Obeticholic acid but not bezafibrate treatment improves cholestasis-induced cognitive decline L Gee, R Burgoyne, F Lebeau, D Jones, F Oakley Journal of Hepatology 73, S198, 2020 | | 2020 |
Translational pharmacology of an inhaled small molecule? v? 6 integrin inhibitor for idiopathic pulmonary fibrosis AE John, RH Graves, KT Pun, G Vitulli, EJ Forty, PF Mercer, JL Morrell, ... Nature Communications 11 (1), 0 | | |