| Renal transporters in drug development. KM Morrissey, SL Stocker, MB Wittwer, L Xu, KM Giacomini Annual review of pharmacology and toxicology 53 (1), 503-529, 2013 | 338 | 2013 |
| FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation T Klein, D Abgottspon, M Wittwer, S Rabbani, J Herold, X Jiang, S Kleeb, ... Journal of medicinal chemistry 53 (24), 8627-8641, 2010 | 271 | 2010 |
| Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance MJ Zamek‐Gliszczynski, ME Taub, PP Chothe, X Chu, KM Giacomini, ... Clinical Pharmacology & Therapeutics 104 (5), 890-899, 2018 | 219 | 2018 |
| Antiadhesion Therapy for Urinary Tract Infections A Balanced PK/PD Profile Proved To Be Key for Success X Jiang, D Abgottspon, S Kleeb, S Rabbani, M Scharenberg, M Wittwer, ... Journal of medicinal chemistry 55 (10), 4700-4713, 2012 | 158 | 2012 |
| Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling MB Wittwer, AA Zur, N Khuri, Y Kido, A Kosaka, X Zhang, KM Morrissey, ... Journal of medicinal chemistry 56 (3), 781-795, 2013 | 151 | 2013 |
| Fundamental aspects of DMPK optimization of targeted protein degraders C Cantrill, P Chaturvedi, C Rynn, JP Schaffland, I Walter, MB Wittwer Drug Discovery Today 25 (6), 969-982, 2020 | 113 | 2020 |
| pK a determination by 1 H NMR spectroscopy–An old methodology revisited J Bezençon, MB Wittwer, B Cutting, M Smieško, B Wagner, M Kansy, ... Journal of pharmaceutical and biomedical analysis 93, 147-155, 2014 | 109 | 2014 |
| Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists O Schwardt, S Rabbani, M Hartmann, D Abgottspon, M Wittwer, S Kleeb, ... Bioorganic & medicinal chemistry 19 (21), 6454-6473, 2011 | 106 | 2011 |
| Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice ED Mock, M Mustafa, O Gunduz-Cinar, R Cinar, GN Petrie, V Kantae, X Di, ... Nature chemical biology 16 (6), 667-675, 2020 | 72 | 2020 |
| Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R) D Stokmaier, O Khorev, B Cutting, R Born, D Ricklin, TOG Ernst, F Böni, ... Bioorganic & medicinal chemistry 17 (20), 7254-7264, 2009 | 64 | 2009 |
| Chemical development of intracellular protein heterodimerizers D Erhart, M Zimmermann, O Jacques, MB Wittwer, B Ernst, E Constable, ... Chemistry & biology 20 (4), 549-557, 2013 | 63 | 2013 |
| The effect of famotidine, a MATE1-selective inhibitor, on the pharmacokinetics and pharmacodynamics of metformin JE Hibma, AA Zur, RA Castro, MB Wittwer, RJ Keizer, SW Yee, ... Clinical pharmacokinetics 55 (6), 711-721, 2016 | 59 | 2016 |
| High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach A Schlessinger, MB Wittwer, A Dahlin, N Khuri, M Bonomi, H Fan, ... Journal of Biological Chemistry 287 (45), 37745-37756, 2012 | 50 | 2012 |
| From a library of MAG antagonists to nanomolar CD22 ligands S Mesch, K Lemme, M Wittwer, H Koliwer‐Brandl, O Schwardt, S Kelm, ... ChemMedChem 7 (1), 134-143, 2012 | 46 | 2012 |
| Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation S Mesch, D Moser, DS Strasser, A Kelm, B Cutting, G Rossato, A Vedani, ... Journal of medicinal chemistry 53 (4), 1597-1615, 2010 | 42 | 2010 |
| A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome A Dahlin, M Wittwer, M De La Cruz, JM Woo, R Bam, V Scharen-Guivel, ... Pharmacogenetics and genomics 25 (2), 82, 2015 | 39 | 2015 |
| Transporters in drug development: International transporter consortium update on emerging transporters of clinical importance MJ Zamek‐Gliszczynski, V Sangha, H Shen, B Feng, MB Wittwer, ... Clinical Pharmacology & Therapeutics 112 (3), 485-500, 2022 | 34 | 2022 |
| Nitric oxide–independent soluble guanylate cyclase activation improves vascular function and cardiac remodeling in sickle cell disease KP Potoka, KC Wood, JJ Baust, M Bueno, SA Hahn, RR Vanderpool, ... American Journal of Respiratory Cell and Molecular Biology 58 (5), 636-647, 2018 | 31 | 2018 |
| ITC commentary on metformin clinical drug-drug interaction study design that enables an efficacy-and safety-based dose adjustment decision MJ Zamek-Gliszczynski, X Chu, JA Cook, JM Custodio, A Galetin, ... Clinical Pharmacology and Therapeutics, 2018 | 30 | 2018 |
| Application of the extended clearance classification system (ECCS) in drug discovery and development: selection of appropriate in vitro tools and clearance prediction K Umehara, C Cantrill, MB Wittwer, E Di Lenarda, F Klammers, A Ekiciler, ... Drug Metabolism and Disposition 48 (10), 849-860, 2020 | 26 | 2020 |
