EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma B Mukherjee, B McEllin, CV Camacho, N Tomimatsu, S Sirasanagandala, ... Cancer research 69 (10), 4252-4259, 2009 | 317 | 2009 |
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection T Costelloe, R Louge, N Tomimatsu, B Mukherjee, E Martini, B Khadaroo, ... Nature 489 (7417), 581-584, 2012 | 297 | 2012 |
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly (ADP-ribose) polymerase inhibitors B McEllin, CV Camacho, B Mukherjee, B Hahm, N Tomimatsu, ... Cancer research 70 (13), 5457-5464, 2010 | 279 | 2010 |
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks E Bolderson, N Tomimatsu, DJ Richard, D Boucher, R Kumar, TK Pandita, ... Nucleic acids research 38 (6), 1821-1831, 2010 | 224 | 2010 |
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice N Tomimatsu, B Mukherjee, M Catherine Hardebeck, M Ilcheva, ... Nature communications 5 (1), 3561, 2014 | 214 | 2014 |
The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses B Mukherjee, N Tomimatsu, K Amancherla, CV Camacho, ... Neoplasia 14 (1), 34-IN8, 2012 | 202 | 2012 |
Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma CR Gil del Alcazar, MC Hardebeck, B Mukherjee, N Tomimatsu, X Gao, ... Clinical cancer research 20 (5), 1235-1248, 2014 | 172 | 2014 |
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions N Tomimatsu, B Mukherjee, K Deland, A Kurimasa, E Bolderson, ... DNA repair 11 (4), 441-448, 2012 | 157 | 2012 |
Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells N Tomimatsu, B Mukherjee, S Burma EMBO reports 10 (6), 629-635, 2009 | 153 | 2009 |
DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair N Tomimatsu, B Mukherjee, JL Harris, FL Boffo, MC Hardebeck, PR Potts, ... Journal of Biological Chemistry 292 (26), 10779-10790, 2017 | 85 | 2017 |
Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence E Fletcher-Sananikone, S Kanji, N Tomimatsu, LFM Di Cristofaro, ... Cancer research 81 (23), 5935-5947, 2021 | 80 | 2021 |
AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells P Raghavan, V Tumati, L Yu, N Chan, N Tomimatsu, S Burma, RG Bristow, ... International Journal of Radiation Oncology* Biology* Physics 84 (4), e507-e514, 2012 | 62 | 2012 |
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks N Tomimatsu, CGT Tahimic, A Otsuki, S Burma, A Fukuhara, K Sato, ... Journal of biological chemistry 282 (14), 10138-10145, 2007 | 61 | 2007 |
Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells CGT Tahimic, N Tomimatsu, R Nishigaki, A Fukuhara, T Toda, K Kaibuchi, ... Biochemical and biophysical research communications 340 (4), 1244-1250, 2006 | 61 | 2006 |
Modulation of the DNA-damage response to HZE particles by shielding B Mukherjee, CV Camacho, N Tomimatsu, J Miller, S Burma DNA repair 7 (10), 1717-1730, 2008 | 36 | 2008 |
Immunofluorescence-based methods to monitor DNA end resection B Mukherjee, N Tomimatsu, S Burma Stress responses: methods and protocols, 67-75, 2015 | 33 | 2015 |
Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions JM Daley, N Tomimatsu, G Hooks, W Wang, AS Miller, X Xue, KA Nguyen, ... Nature communications 11 (1), 3088, 2020 | 31 | 2020 |
DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification CV Camacho, PK Todorova, MC Hardebeck, N Tomimatsu, ... Oncogene 34 (8), 1064-1072, 2015 | 31 | 2015 |
Construction of a novel expression system on a human artificial chromosome A Otsuki, CGT Tahimic, N Tomimatsu, M Katoh, DJ Chen, A Kurimasa, ... Biochemical and biophysical research communications 329 (3), 1018-1025, 2005 | 22 | 2005 |
INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells C Morris, N Tomimatsu, DJ Richard, D Cluet, S Burma, KK Khanna, ... Cancer research 72 (8), 2006-2016, 2012 | 19 | 2012 |