| Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor N Jacobson, M Andrews, AR Shepard, D Nishimura, C Searby, JH Fingert, ... Human molecular genetics 10 (2), 117-125, 2001 | 354 | 2001 |
| TGFβ2-induced changes in human trabecular meshwork: implications for intraocular pressure DL Fleenor, AR Shepard, PE Hellberg, N Jacobson, IH Pang, AF Clark Investigative ophthalmology & visual science 47 (1), 226-234, 2006 | 351 | 2006 |
| Adenoviral gene transfer of active human transforming growth factor-β2 elevates intraocular pressure and reduces outflow facility in rodent eyes AR Shepard, JC Millar, IH Pang, N Jacobson, WH Wang, AF Clark Investigative ophthalmology & visual science 51 (4), 2067-2076, 2010 | 216 | 2010 |
| Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues AF Clark, HT Steely, JE Dickerson, S English-Wright, K Stropki, ... Investigative ophthalmology & visual science 42 (8), 1769-1780, 2001 | 195 | 2001 |
| α1C (CaV1.2) L-type calcium channel mediates mechanosensitive calcium regulation GL Lyford, PR Strege, A Shepard, Y Ou, L Ermilov, SM Miller, SJ Gibbons, ... American Journal of Physiology-Cell Physiology 283 (3), C1001-C1008, 2002 | 140 | 2002 |
| Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage IH Pang, EC Johnson, L Jia, WO Cepurna, AR Shepard, MR Hellberg, ... Investigative ophthalmology & visual science 46 (4), 1313-1321, 2005 | 127 | 2005 |
| Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure AR Shepard, N Jacobson, JC Millar, IH Pang, HT Steely, CC Searby, ... Human molecular genetics 16 (6), 609-617, 2007 | 125 | 2007 |
| Exon-level expression profiling of ocular tissues AH Wagner, VN Anand, WH Wang, JE Chatterton, D Sun, AR Shepard, ... Experimental eye research 111, 105-111, 2013 | 123 | 2013 |
| Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells AR Shepard, N Jacobson, JH Fingert, EM Stone, VC Sheffield, AF Clark Investigative ophthalmology & visual science 42 (13), 3173-3181, 2001 | 88 | 2001 |
| Two CGTCA motifs and a GHF1/Pit1 binding site mediate cAMP-dependent protein kinase A regulation of human growth hormone gene expression in rat anterior pituitary GC cells. AR Shepard, W Zhang, NL Eberhardt Journal of Biological Chemistry 269 (3), 1804-1814, 1994 | 84 | 1994 |
| Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXC1 using quantitative RT-PCR WH Wang, LG McNatt, AR Shepard, N Jacobson, DY Nishimura, ... Mol Vis 7, 89-94, 2001 | 68 | 2001 |
| Magnetic bead capture of cDNAs from double-stranded plasmid cDNA libraries AR Shepard, JL Rae Nucleic acids research 25 (15), 3478-3480, 1997 | 61 | 1997 |
| Thyroid hormone responsiveness in human growth hormone-related genes. Possible correlation with receptor-induced DNA conformational changes. F Leidig, AR Shepard, WG Zhang, A Stelter, PA Cattini, JD Baxter, ... Journal of Biological Chemistry 267 (2), 913-921, 1992 | 58 | 1992 |
| RNAi inhibition of CTGF for treatment of ocular disorders AR Shepard, IH Pang US Patent 7,622,454, 2009 | 46 | 2009 |
| TGF-β2–mediated ocular hypertension is attenuated in SPARC-null mice SS Swaminathan, DJ Oh, MH Kang, AR Shepard, IH Pang, DJ Rhee Investigative ophthalmology & visual science 55 (7), 4084-4097, 2014 | 45 | 2014 |
| RNAi-mediated inhibition of ocular targets AR Shepard, JE Chatterton, AF Clark, MB Wax US Patent 7,592,324, 2009 | 44 | 2009 |
| Control of intraocular pressure using alk5 modulation agents D Fleenor, IH Pang, A Shepard, M Hellberg, A Clark, P Klimko US Patent App. 11/611,312, 2007 | 44 | 2007 |
| Kv3. 3 potassium channels in lens epithelium and corneal endothelium JL RAE, AR SHEPARD Experimental eye research 70 (3), 339-348, 2000 | 43 | 2000 |
| An initiator element is required for maximal human chorionic somatomammotropin gene promoter and enhancer function SW Jiang, AR Shepard, NL Eberhardt Journal of Biological Chemistry 270 (8), 3683-3692, 1995 | 43 | 1995 |
| RNAi-mediated inhibition of ocular hypertension targets A Shepard, J Chatterton, A Clark US Patent App. 11/344,702, 2006 | 38 | 2006 |
