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| A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model R Postina, A Schroeder, I Dewachter, J Bohl, U Schmitt, E Kojro, ... The Journal of clinical investigation 113 (10), 1456-1464, 2004 | 887 | 2004 |
| Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice MT Heneka, M Sastre, L Dumitrescu-Ozimek, A Hanke, I Dewachter, ... Brain 128 (6), 1442-1453, 2005 | 728 | 2005 |
| Association of amyloid and tau with cognition in preclinical Alzheimer disease: a longitudinal study BJ Hanseeuw, RA Betensky, HIL Jacobs, AP Schultz, J Sepulcre, ... JAMA neurology 76 (8), 915-924, 2019 | 669 | 2019 |
| Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ M Sastre, I Dewachter, S Rossner, N Bogdanovic, E Rosen, P Borghgraef, ... Proceedings of the National Academy of Sciences 103 (2), 443-448, 2006 | 475 | 2006 |
| Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice R Etcheberrigaray, M Tan, I Dewachter, C Kuipéri, I Van der Auwera, ... Proceedings of the National Academy of Sciences 101 (30), 11141-11146, 2004 | 453 | 2004 |
| Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through … M Sastre, I Dewachter, GE Landreth, TM Willson, T Klockgether, ... Journal of Neuroscience 23 (30), 9796-9804, 2003 | 448 | 2003 |
| Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology J Chapuis, F Hansmannel, M Gistelinck, A Mounier, ... Molecular psychiatry 18 (11), 1225-1234, 2013 | 412 | 2013 |
| Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP [V717I] transgenic mice MT Heneka, M Sastre, L Dumitrescu-Ozimek, I Dewachter, J Walter, ... Journal of neuroinflammation 2, 1-12, 2005 | 405 | 2005 |
| Hallmarks of neurodegenerative diseases DM Wilson, MR Cookson, L Van Den Bosch, H Zetterberg, DM Holtzman, ... Cell 186 (4), 693-714, 2023 | 391 | 2023 |
| Tau association with synaptic vesicles causes presynaptic dysfunction L Zhou, J McInnes, K Wierda, M Holt, AG Herrmann, RJ Jackson, ... Nature communications 8 (1), 1-13, 2017 | 368 | 2017 |
| Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding T Gevaert, J Vriens, A Segal, W Everaerts, T Roskams, K Talavera, ... The Journal of clinical investigation 117 (11), 3453-3462, 2007 | 366 | 2007 |
| Amyloid activates GSK-3β to aggravate neuronal tauopathy in bigenic mice D Terwel, D Muyllaert, I Dewachter, P Borghgraef, S Croes, H Devijver, ... The American journal of pathology 172 (3), 786-798, 2008 | 365 | 2008 |
| What is the evidence that tau pathology spreads through prion-like propagation? A Mudher, M Colin, S Dujardin, M Medina, I Dewachter, SM Alavi Naini, ... Acta neuropathologica communications 5, 1-20, 2017 | 346 | 2017 |
| Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo IC Stancu, N Cremers, H Vanrusselt, J Couturier, A Vanoosthuyse, ... Acta neuropathologica 137, 599-617, 2019 | 317 | 2019 |
| Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism IC Stancu, B Vasconcelos, D Terwel, I Dewachter Molecular neurodegeneration 9, 1-14, 2014 | 317 | 2014 |
| Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein … I Dewachter, D Reversé, N Caluwaerts, L Ris, C Kuipéri, C Van den Haute, ... Journal of Neuroscience 22 (9), 3445-3453, 2002 | 305 | 2002 |
| Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide B Permanne, C Adessi, GP Saborio, S Fraga, MJ Frossard, J Van Dorpe, ... The FASEB Journal 16 (8), 860-862, 2002 | 303 | 2002 |
| Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons J Van Dorpe, L Smeijers, I Dewachter, D Nuyens, K Spittaels, ... The American journal of pathology 157 (4), 1283-1298, 2000 | 266 | 2000 |
| Expression in brain of amyloid precursor protein mutated in the alpha‐secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. D Moechars, K Lorent, B De Strooper, I Dewachter, F Van Leuven The EMBO Journal 15 (6), 1265-1274, 1996 | 264 | 1996 |
