| Synthesis and Structure−Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors T Heinrich, H Böttcher, R Gericke, GD Bartoszyk, S Anzali, CA Seyfried, ... Journal of medicinal chemistry 47 (19), 4684-4692, 2004 | 161 | 2004 |
| Palladium-catalyzed carbonylation of haloindoles: No need for protecting groups K Kumar, A Zapf, D Michalik, A Tillack, T Heinrich, H Böttcher, M Arlt, ... Organic Letters 6 (1), 7-10, 2004 | 102 | 2004 |
| Biologically Active Compounds through Catalysis: Efficient Synthesis of N‐(Heteroarylcarbonyl)‐N′‐(arylalkyl)piperazines K Kumar, D Michalik, I Garcia Castro, A Tillack, A Zapf, M Arlt, T Heinrich, ... Chemistry–A European Journal 10 (3), 746-757, 2004 | 100 | 2004 |
| Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors T Heinrich, J Seenisamy, L Emmanuvel, SS Kulkarni, J Bomke, F Rohdich, ... Journal of medicinal chemistry 56 (3), 1160-1170, 2013 | 68 | 2013 |
| Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity T Heinrich, H Böttcher, K Schiemann, G Hölzemann, M Schwarz, ... Bioorganic & medicinal chemistry 12 (18), 4843-4852, 2004 | 65 | 2004 |
| Substituted indoles O Schadt, H Böttcher, J Leibrock, K Schiemann, T Heinrich, G Hölzemann, ... US Patent 7,572,796, 2009 | 51 | 2009 |
| Metalated 2‐Alkenylsulfoximides in Asymmetric Synthesis: Diastereoselective Preparation of Highly Substituted Pyrrolidine Derivatives M Reggelin, T Heinrich Angewandte Chemie International Edition 37 (20), 2883-2886, 1998 | 50 | 1998 |
| Asymmetric synthesis of highly substituted azapolycyclic compounds via 2-alkenyl sulfoximines: potential scaffolds for peptide mimetics M Reggelin, B Junker, T Heinrich, S Slavik, P Bühle Journal of the American Chemical Society 128 (12), 4023-4034, 2006 | 49 | 2006 |
| Allosteric IGF-1R inhibitors T Heinrich, U Grädler, H Böttcher, A Blaukat, A Shutes ACS medicinal chemistry letters 1 (5), 199-203, 2010 | 48 | 2010 |
| Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 BT Berger, M Amaral, DB Kokh, A Nunes-Alves, D Musil, T Heinrich, ... Cell Chemical Biology 28 (5), 686-698. e7, 2021 | 45 | 2021 |
| Pyrrolidone derivatives for use as MetAP-2 inhibitors T Heinrich, M Krier, T Knoechel, A Jonczyk, F Zenke, H Enderle US Patent 8,846,694, 2014 | 45 | 2014 |
| (1H-indol-7-yl)-(pyrimidin-2-ylamino) methanone derivatives and related compounds as IGF-R1 inhibitors for the treatment of cancer T Heinrich, A Blaukat, M Kordowicz US Patent 8,114,882, 2012 | 44 | 2012 |
| A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone T Heinrich, H Böttcher Bioorganic & medicinal chemistry letters 14 (10), 2681-2684, 2004 | 44 | 2004 |
| A short and efficient synthesis of N-aryl-and N-heteroaryl-N′-(arylalkyl) piperazines D Michalik, K Kumar, A Zapf, A Tillack, M Arlt, T Heinrich, M Beller Tetrahedron letters 45 (10), 2057-2061, 2004 | 44 | 2004 |
| Convenient and Reliable Routes Towards 2‐Aminothiazoles: Palladium‐Catalyzed versus Copper‐Catalyzed Aminations of Halothiazoles S Toulot, T Heinrich, FR Leroux Advanced Synthesis & Catalysis 355 (16), 3263-3272, 2013 | 41 | 2013 |
| Indolebutylamines as Selective 5-HT1A Agonists T Heinrich, H Böttcher, GD Bartoszyk, HE Greiner, CA Seyfried, ... Journal of medicinal chemistry 47 (19), 4677-4683, 2004 | 38 | 2004 |
| Fragment-based discovery of focal adhesion kinase inhibitors U Grädler, J Bomke, D Musil, V Dresing, M Lehmann, G Hölzemann, ... Bioorganic & medicinal chemistry letters 23 (19), 5401-5409, 2013 | 36 | 2013 |
| Syntheses of novel 2, 3-diaryl-substituted 5-cyano-4-azaindoles exhibiting c-Met inhibition activity H Koolman, T Heinrich, H Böttcher, W Rautenberg, M Reggelin Bioorganic & medicinal chemistry letters 19 (7), 1879-1882, 2009 | 35 | 2009 |
| Systematic optimization of a lead‐structure identities for a selective short peptide agonist for the human orphan receptor BRS‐3 D Weber, C Berger, T Heinrich, P Eickelmann, J Antel, H Kessler Journal of peptide science: an official publication of the European Peptide …, 2002 | 35 | 2002 |
| Metallierte 2‐Alkenylsulfoximide in der asymmetrischen Synthese: diastereoselektive Herstellung hochsubstituierter Pyrrolidinderivate M Reggelin, T Heinrich Angewandte Chemie 110 (20), 3005-3008, 1998 | 33 | 1998 |
