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Jadd Shelton
Jadd Shelton
未知所在单位机构
在 autoliv.com 的电子邮件经过验证
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Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
J Shelton, X Lu, JA Hollenbaugh, JH Cho, F Amblard, RF Schinazi
Chemical reviews 116 (23), 14379-14455, 2016
3592016
Chutes and ladders in hepatitis C nucleoside drug development
SJ Coats, EC Garnier-Amblard, F Amblard, M Ehteshami, S Amiralaei, ...
Antiviral research 102, 119-147, 2014
792014
Substrates and Inhibitors of SAMHD1
JA Hollenbaugh, J Shelton, S Tao, S Amiralaei, P Liu, X Lu, RW Goetze, ...
PloS one 12 (1), e0169052, 2017
532017
A broad spectrum anticancer nucleoside with selective toxicity against human colon cells in vitro
JR Shelton, SR Burt, MA Peterson
Bioorganic & medicinal chemistry letters 21 (5), 1484-1487, 2011
222011
Comparison of Three 2′-C-Methyl Guanosine Prodrugs for Hepatitis C including a Novel β-D-2′-C-Me-2, 6-Diaminopurine Ribonucleoside Phosphoramidate (RS-1389): Interspecies …
S Tao, Z Longhu, H Zhang, S Zhou, S Amiralaei, J Shelton, SJ Coats, ...
Hepatology 60, 1170A-1171A, 2014
212014
The effects of estradiol and catecholestrogens on uterine glycogen metabolism in mink (Neovison vison)
J Rose, J Hunt, J Shelton, S Wyler, D Mecham
Theriogenology 75 (5), 857-866, 2011
212011
Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N6, 5′-bis-ureido-and 5′-carbamoyl-N6-ureidoadenosine derivatives
JR Shelton, CE Cutler, M Oliveira, J Balzarini, MA Peterson
Bioorganic & medicinal chemistry 20 (2), 1008-1019, 2012
162012
Biochemical characterization of the active anti-hepatitis C virus metabolites of 2, 6-diaminopurine ribonucleoside prodrug compared to sofosbuvir and BMS-986094
M Ehteshami, S Tao, T Ozturk, L Zhou, JH Cho, H Zhang, S Amiralaei, ...
Antimicrobial agents and chemotherapy 60 (8), 4659-4669, 2016
132016
Synthesis and SAR of 2′, 3′-bis-O-substituted N6, 5′-bis-ureidoadenosine derivatives: Implications for prodrug delivery and mechanism of action
JR Shelton, CE Cutler, MS Browning, J Balzarini, MA Peterson
Bioorganic & medicinal chemistry letters 22 (19), 6067-6071, 2012
132012
Nucleotide substrate specificity of anti-hepatitis C virus nucleoside analogs for human mitochondrial RNA polymerase
M Ehteshami, L Zhou, S Amiralaei, JR Shelton, JH Cho, H Zhang, H Li, ...
Antimicrobial agents and chemotherapy 61 (8), 10.1128/aac. 00492-17, 2017
112017
Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro
JR Shelton, J Balzarini, MA Peterson
Bioorganic & Medicinal Chemistry Letters 24 (21), 5107-5110, 2014
72014
Intracellular metabolism and potential cardiotoxicity of a β-D-2’-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication
S Tao, L Zhou, H Zhang, S Zhou, S Amiralaei, J Shelton, M Ehteshami, ...
Nucleosides, nucleotides & nucleic acids 39 (1-3), 204-224, 2020
52020
The Effects of Estradiol and Catecholestrogens on the Expression and Activity of Enzymes Regulating Glycogen Metabolism in the Uterus of the Mink.
J Rose, J Hunt, J Shelton, S Wyler, D Mecham
Biology of Reproduction 78 (Suppl_1), 93-93, 2008
52008
Efficient synthesis of 5′-O (N)-carbamyl and-polycarbamyl nucleosides
JR Shelton, MA Peterson
Tetrahedron Letters 54 (50), 6882-6885, 2013
32013
A 4-N-Hydroxycytidine Ribonucleoside Phosphorami-date Delivers Intracellularly Three Distinct Active 5′-Tri-phosphate Nucleosides that are Potent Inhibitors of HCV Polymerase …
RF Schinazi, F Amblard, S Tao, M Ehteshami, S Amiralaei, H Li, J Shelton, ...
Hepatology 60, 1162A, 2014
2014
Phosphoramidate Prodrugs of β-D-2 ″-C-Me-2, 6-diaminopurine Ribonucleoside are Potent Inhibitors of Hepatitis C Virus (HCV) Replication Delivering Two Active Nucleoside …
RF Schinazi, Z Longhu, H Zhang, M Ehteshami, S Tao, LC Bassit, ...
Hepatology 58, 437A, 2013
2013
Biochemical characterization of beta-D-2'-C-methyl-2, 6-diaminopurine-ribonucleoside-5'-triphosphate as a potent inhibitor of hepatitis C virus (HCV) polymerase
M Ehteshami, S Amiralaei, JR Shelton, S Tao, JE Suesserman, HW Zhang, ...
ANTIVIRAL THERAPY 18, A10-A10, 2013
2013
Synthesis and Biological Evaluation of Various Derivatives of a Broad-Spectrum Anticancer Nucleoside
JR Shelton
Brigham Young University, 2012
2012
1R= Et3Si, tBuPh2Si,(iPr) 3Si, tBuMe2Si 2R= CH3,(CH3) 2CH, n-C3H7, C (CH3) 3, n-C5H11, C6H5, n-C7H15, n-C9H19, n-C15H31
CW Rivero, EC De Benedetti, JE Sambeth, ME Lozano, JA Trelles, ...
Bioorganic & Medicinal Chemistry Letters 22 (19), 6025-6038, 2012
2012
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