Synthetic lethality and cancer NJ O'Neil, ML Bailey, P Hieter Nature Reviews Genetics 18 (10), 613-623, 2017 | 639 | 2017 |
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human D Bergamaschi, Y Samuels, NJ O'Neil, G Trigiante, T Crook, JK Hsieh, ... Nature genetics 33 (2), 162-167, 2003 | 527 | 2003 |
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017 | 518 | 2017 |
RTEL1 maintains genomic stability by suppressing homologous recombination LJ Barber, JL Youds, JD Ward, MJ McIlwraith, NJ O'Neil, MIR Petalcorin, ... Cell 135 (2), 261-271, 2008 | 459 | 2008 |
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes M Le Gallo, AJ O'Hara, ML Rudd, ME Urick, NF Hansen, NJ O'Neil, ... Nature genetics 44 (12), 1310-1315, 2012 | 429 | 2012 |
RTEL-1 enforces meiotic crossover interference and homeostasis JL Youds, DG Mets, MJ McIlwraith, JS Martin, JD Ward, NJ ONeil, ... Science 327 (5970), 1254-1258, 2010 | 201 | 2010 |
MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome JR Tyson, NJ O'Neil, M Jain, HE Olsen, P Hieter, TP Snutch Genome research 28 (2), 266-274, 2018 | 169 | 2018 |
DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair JL Youds, LJ Barber, JD Ward, SJ Collis, NJ O'Neil, SJ Boulton, AM Rose Molecular and cellular biology 28 (5), 1470-1479, 2008 | 116 | 2008 |
The use of functional genomics in C. elegans for studying human development and disease PE Kuwabara, N O'neil Journal of inherited metabolic disease 24 (2), 127-138, 2001 | 103 | 2001 |
TILLING is an effective reverse genetics technique for Caenorhabditis elegans EJ Gilchrist, NJ O'Neil, AM Rose, MC Zetka, GW Haughn BMC genomics 7, 1-16, 2006 | 100 | 2006 |
Glioblastoma Cells Containing Mutations in the Cohesin Component STAG2 Are Sensitive to PARP Inhibition ML Bailey, NJ O'Neil, DM van Pel, DA Solomon, T Waldman, P Hieter Molecular cancer therapeutics 13 (3), 724-732, 2014 | 89 | 2014 |
Synthetic lethality of cohesins with PARPs and replication fork mediators JL McLellan, NJ O'Neil, I Barrett, E Ferree, DM van Pel, K Ushey, ... PLoS genetics 8 (3), e1002574, 2012 | 88 | 2012 |
Joint Molecule Resolution Requires the Redundant Activities of MUS-81 and XPF-1 during Caenorhabditis elegans Meiosis NJ O'Neil, JS Martin, JL Youds, JD Ward, MIR Petalcorin, AM Rose, ... PLoS genetics 9 (7), e1003582, 2013 | 80 | 2013 |
Homologous Recombination Is Required for Genome Stability in the Absence of DOG-1 in Caenorhabditis elegans JL Youds, NJ O'Neil, AM Rose Genetics 173 (2), 697-708, 2006 | 80 | 2006 |
Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1 JW Astin, NJ O’Neil, PE Kuwabara DNA repair 7 (2), 267-280, 2008 | 66 | 2008 |
The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans LM Kuervers, CL Jones, NJ O'neil, DL Baillie Molecular Genetics and Genomics 270, 121-131, 2003 | 65 | 2003 |
Identification and analysis of internal promoters in Caenorhabditis elegans operons P Huang, ED Pleasance, JS Maydan, R Hunt-Newbury, NJ O’Neil, A Mah, ... Genome research 17 (10), 1478-1485, 2007 | 61 | 2007 |
Synthetic Lethal Genetic Interactions That Decrease Somatic Cell Proliferation in Caenorhabditis elegans Identify the Alternative RFCCTF18 as a Candidate … J McLellan, N O'Neil, S Tarailo, J Stoepel, J Bryan, A Rose, P Hieter Molecular biology of the cell 20 (24), 5306-5313, 2009 | 53 | 2009 |
Synthetic lethality and cancer: cohesin and PARP at the replication fork NJ O’Neil, DM van Pel, P Hieter Trends in Genetics 29 (5), 290-297, 2013 | 46 | 2013 |
RNA-mediated interference as a tool for identifying drug targets NJ O’Neil, RL Martin, ML Tomlinson, MR Jones, A Coulson, PE Kuwabara American Journal of Pharmacogenomics 1, 45-53, 2001 | 45 | 2001 |