| Mechanism and catalysis of nucleophilic substitution in phosphate esters RJG Thatcher, R Kluger Advances in Physical Organic Chemistry 25, 99-265, 1989 | 418 | 1989 |
| Thiamin diphosphate: a mechanistic update on enzymic and nonenzymic catalysis of decarboxylation R Kluger Chemical reviews 87 (5), 863-876, 1987 | 315 | 1987 |
| Thiamin diphosphate catalysis: enzymic and nonenzymic covalent intermediates R Kluger, K Tittmann Chemical reviews 108 (6), 1797-1833, 2008 | 294 | 2008 |
| Electrostatic stabilization can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions JP Guthrie, R Kluger Journal of the American Chemical Society 115 (24), 11569-11572, 1993 | 190 | 1993 |
| Chemical cross-linking and protein–protein interactions—a review with illustrative protocols R Kluger, A Alagic Bioorganic chemistry 32 (6), 451-472, 2004 | 156 | 2004 |
| pH-Product and pH-rate profiles for the hydrolysis of methyl ethylene phosphate. Rate-limiting pseudorotation R Kluger, F Covitz, E Dennis, LD Williams, FH Westheimer Journal of the American Chemical Society 91 (22), 6066-6072, 1969 | 147 | 1969 |
| Active site generated analogs of reactive intermediates in enzymic reactions. Potent inhibition of pyruvate dehydrogenase by a phosphonate analog of pyruvate R Kluger, DC Pike Journal of the American Chemical Society 99 (13), 4504-4506, 1977 | 128 | 1977 |
| Allosteric transition intermediates modelled by crosslinked haemoglobins MA Schumacher, MM Dixon, R Kluger, RT Jones, RG Brennan Nature 375 (6526), 84-87, 1995 | 98 | 1995 |
| Thiamin-catalyzed decarboxylation of pyruvate. Synthesis and reactivity analysis of the central, elusive intermediate,. alpha.-lactylthiamin R Kluger, J Chin, T Smyth Journal of the American Chemical Society 103 (4), 884-888, 1981 | 83 | 1981 |
| Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate S Lüdtke, P Neumann, KM Erixon, F Leeper, R Kluger, R Ficner, ... Nature chemistry 5 (9), 762-767, 2013 | 75 | 2013 |
| On the origins of enhanced reactivity of five-membered cyclic phosphate esters. The relative contributions of enthalpic and entropic factors R Kluger, SD Taylor Journal of the American Chemical Society 112 (18), 6669-6671, 1990 | 70 | 1990 |
| Decarboxylation via addition of water to a carboxyl group: acid catalysis of pyrrole-2-carboxylic acid SOC Mundle, R Kluger Journal of the American Chemical Society 131 (33), 11674-11675, 2009 | 69 | 2009 |
| Red cell substitutes from hemoglobin—do we start all over again? R Kluger Current opinion in chemical biology 14 (4), 538-543, 2010 | 67 | 2010 |
| Phosphonate analogues of pyruvate. Probes of substrate binding to pyruvate oxidase and other thiamin pyrophosphate-dependent decarboxylases TA O'Brien, R Kluger, DC Pike, RB Gennis Biochimica et Biophysica Acta (BBA)-Enzymology 613 (1), 10-17, 1980 | 67 | 1980 |
| Allosteric intermediates indicate R2 is the liganded hemoglobin end state MA Schumacher, EE Zheleznova, KS Poundstone, R Kluger, RT Jones, ... Proceedings of the National Academy of Sciences 94 (15), 7841-7844, 1997 | 65 | 1997 |
| Hydrolytic decarboxylation of carboxylic acids and the formation of protonated carbonic acid SOC Mundle, G Lacrampe-Couloume, BS Lollar, R Kluger Journal of the American Chemical Society 132 (7), 2430-2436, 2010 | 61 | 2010 |
| Pharmaceutical composition and treatment R Kluger, M Mamelak US Patent 4,738,985, 1988 | 61 | 1988 |
| Three-point crosslinking: potential red cell substitutes from the reaction of trimesoyl tris (methyl phosphate) with hemoglobin R Kluger, J Wodzinska, RT Jones, C Head, TS Fujita, DT Shih Biochemistry 31 (33), 7551-7559, 1992 | 60 | 1992 |
| Carboxylic acid participation in amide hydrolysis. Evidence that separation of a nonbonded complex can be rate determining R Kluger, J Chin Journal of the American Chemical Society 104 (10), 2891-2897, 1982 | 58 | 1982 |
| Interaction of pyruvate-thiamin diphosphate adducts with pyruvate decarboxylase. Catalysis through" closed" transition states R Kluger, T Smyth Journal of the American Chemical Society 103 (5), 1214-1216, 1981 | 58 | 1981 |
Scott O. C. MundleGreat Lakes Institute for Environmental Research在 uwindsor.ca 的电子邮件经过验证
