| Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells S Tirman, A Quinet, M Wood, A Meroni, E Cybulla, J Jackson, S Pegoraro, ... Molecular cell 81 (19), 4026-4040. e8, 2021 | 109 | 2021 |
| cGAS suppresses genomic instability as a decelerator of replication forks H Chen, H Chen, J Zhang, Y Wang, A Simoneau, H Yang, AS Levine, ... Science advances 6 (42), eabb8941, 2020 | 88 | 2020 |
| The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells A Simoneau, R Xiong, L Zou Genes & Development 35 (17-18), 1271-1289, 2021 | 58 | 2021 |
| TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch T Yadav, JM Zhang, J Ouyang, W Leung, A Simoneau, L Zou Molecular cell 82 (21), 3985-4000. e4, 2022 | 44 | 2022 |
| CDC7-independent G1/S transition revealed by targeted protein degradation JM Suski, N Ratnayeke, M Braun, T Zhang, V Strmiska, W Michowski, ... Nature 605 (7909), 357-365, 2022 | 44 | 2022 |
| BRG1 loss predisposes lung cancers to replicative stress and ATR dependency M Gupta, CP Concepcion, CG Fahey, H Keshishian, A Bhutkar, ... Cancer research 80 (18), 3841-3854, 2020 | 41 | 2020 |
| Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage A Simoneau, N Delgoshaie, I Celic, J Dai, N Abshiru, S Costantino, ... Genetics 200 (1), 185-205, 2015 | 39 | 2015 |
| An extending ATR–CHK1 circuitry: the replication stress response and beyond A Simoneau, L Zou Current opinion in genetics & development 71, 92-98, 2021 | 32 | 2021 |
| Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress A Simoneau, E Ricard, S Weber, I Hammond-Martel, LH Wong, A Sellam, ... Nucleic Acids Research 44 (6), 2706-2726, 2016 | 30 | 2016 |
| Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progression A Simoneau, X Robellet, AM Ladouceur, D D’Amours Cell Cycle 13 (7), 1078-1090, 2014 | 30 | 2014 |
| CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer T Tsujino, T Takai, K Hinohara, F Gui, T Tsutsumi, X Bai, C Miao, C Feng, ... Nature Communications 14 (1), 252, 2023 | 27 | 2023 |
| Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer M Stanzione, J Zhong, E Wong, TJ LaSalle, JF Wise, A Simoneau, ... Science Advances 8 (19), eabn1229, 2022 | 14 | 2022 |
| Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer N Vidula, T Dubash, MS Lawrence, A Simoneau, A Niemierko, E Blouch, ... Clinical Cancer Research 26 (18), 4852-4862, 2020 | 14 | 2020 |
| Ubiquitinated PCNA drives USP1 synthetic lethality in cancer A Simoneau, JL Engel, M Bandi, K Lazarides, S Liu, SR Meier, AH Choi, ... Molecular Cancer Therapeutics 22 (2), 215-226, 2023 | 12 | 2023 |
| Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae K Desfossés-Baron, I Hammond-Martel, A Simoneau, A Sellam, S Roberts, ... Scientific reports 6 (1), 36013, 2016 | 10 | 2016 |
| An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres A Simoneau, E Ricard, H Wurtele PLoS Genetics 14 (4), e1007356, 2018 | 9 | 2018 |
| ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms W Leung, A Simoneau, S Saxena, J Jackson, PS Patel, M Limbu, ... Cell reports 42 (7), 2023 | 7 | 2023 |
| Calcium influx guards replication forks against exonuclease 1 A Simoneau, L Zou Molecular cell 74 (6), 1103-1105, 2019 | 4 | 2019 |
| Oncogenic KIT induces replication stress and confers cell cycle checkpoint vulnerability in melanoma CN Njauw, Z Ji, DM Pham, A Simoneau, R Kumar, KT Flaherty, L Zou, ... Journal of Investigative Dermatology 142 (5), 1413-1424. e6, 2022 | 3 | 2022 |
| Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins R Tremblay, Y Mehrjoo, O Ahmed, A Simoneau, ME McQuaid, EB Affar, ... Molecular and Cellular Biology 43 (11), 566-595, 2023 | 1 | 2023 |
