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Ian Slaymaker
Ian Slaymaker
Broad Institute
在 broadinstitute.org 的电子邮件经过验证
标题
引用次数
引用次数
年份
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ...
cell 163 (3), 759-771, 2015
47582015
Rationally engineered Cas9 nucleases with improved specificity
IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang
Science 351 (6268), 84-88, 2016
26172016
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ...
Science 353 (6299), aaf5573, 2016
21562016
Crystal structure of Cpf1 in complex with guide RNA and target DNA
T Yamano, H Nishimasu, B Zetsche, H Hirano, IM Slaymaker, Y Li, ...
Cell 165 (4), 949-962, 2016
7022016
Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28
AA Smargon, DBT Cox, NK Pyzocha, K Zheng, IM Slaymaker, ...
Molecular cell 65 (4), 618-630. e7, 2017
5852017
CRISPR enzymes and systems
F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh
US Patent 9,790,490, 2017
5002017
Directed evolution of adenine base editors with increased activity and therapeutic application
NM Gaudelli, DK Lam, HA Rees, NM Solá-Esteves, LA Barrera, DA Born, ...
Nature biotechnology 38 (7), 892-900, 2020
4392020
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker, GW Yeo
Nature Reviews Drug Discovery 19 (12), 839-859, 2020
3022020
Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits
RJ Platt, Y Zhou, IM Slaymaker, AS Shetty, NR Weisbach, JA Kim, ...
Cell reports 19 (2), 335-350, 2017
2022017
High-resolution structure of Cas13b and biochemical characterization of RNA targeting and cleavage
IM Slaymaker, P Mesa, MJ Kellner, S Kannan, E Brignole, J Koob, ...
Cell reports 26 (13), 3741-3751. e5, 2019
1052019
Rationally designed base editors for precise editing of the sickle cell disease mutation
SH Chu, M Packer, H Rees, D Lam, Y Yu, J Marshall, LI Cheng, D Lam, ...
The CRISPR Journal 4 (2), 169-177, 2021
682021
Crispr enzymes and systems
F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker
US Patent 11,781,172, 2023
452023
CRISPR enzymes and systems
F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh
US Patent 10,669,540, 2020
452020
MCM structure and mechanics: what we have learned from archaeal MCM
IM Slaymaker, XS Chen
The Eukaryotic Replisome: a Guide to Protein Structure and Function, 89-111, 2012
342012
Crispr enzyme mutations reducing off-target effects
F Zhang, L Gao, B Zetsche, I Slaymaker
US Patent 10,876,100, 2020
332020
Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology
IM Slaymaker, Y Fu, DB Toso, N Ranatunga, A Brewster, SL Forsburg, ...
Nucleic acids research 41 (5), 3446-3456, 2013
322013
CRISPR–Cas9 mediated DNA unwinding detected using site-directed spin labeling
NS Tangprasertchai, R Di Felice, X Zhang, IM Slaymaker, ...
ACS chemical biology 12 (6), 1489-1493, 2017
252017
Engineering Cas9 for human genome editing
IM Slaymaker, NM Gaudelli
Current Opinion in Structural Biology 69, 86-98, 2021
222021
Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding
AS Brewster, IM Slaymaker, SA Afif, XS Chen
BMC Molecular Biology 11, 1-8, 2010
222010
CRISPR enzymes and systems
F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker
US Patent 10,648,020, 2020
182020
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