| BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway EJ Pone, J Zhang, T Mai, CA White, G Li, JK Sakakura, PJ Patel, ... Nature communications 3 (1), 767, 2012 | 314 | 2012 |
| HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation SR Park, H Zan, Z Pal, J Zhang, A Al-Qahtani, EJ Pone, Z Xu, T Mai, ... Nature immunology 10 (5), 540-550, 2009 | 180 | 2009 |
| 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination Z Xu, Z Fulop, G Wu, EJ Pone, J Zhang, T Mai, LM Thomas, A Al-Qahtani, ... Nature structural & molecular biology 17 (9), 1124-1135, 2010 | 169 | 2010 |
| Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses EJ Pone, H Zan, JS Zhang, A Al-Qahtani, Z Xu, P Casali Critical Reviews™ in Immunology 30 (1), 2010 | 166 | 2010 |
| Targeted selection of HIV-specific antibody mutations by engineering B cell maturation KO Saunders, K Wiehe, M Tian, P Acharya, T Bradley, SM Alam, EP Go, ... Science 366 (6470), eaay7199, 2019 | 135 | 2019 |
| Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH× VL knockin mice reveals multiple tolerance controls L Verkoczy, Y Chen, H Bouton-Verville, J Zhang, M Diaz, J Hutchinson, ... The Journal of Immunology 187 (7), 3785-3797, 2011 | 126 | 2011 |
| Developing an HIV vaccine BF Haynes, DR Burton Science 355 (6330), 1129-1130, 2017 | 119 | 2017 |
| Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages R Zhang, L Verkoczy, K Wiehe, SM Alam, NI Nicely, S Santra, T Bradley, ... Science translational medicine 8 (336), 336ra62-336ra62, 2016 | 104 | 2016 |
| Vaccine induction of heterologous tier 2 HIV-1 neutralizing antibodies in animal models KO Saunders, LK Verkoczy, C Jiang, J Zhang, R Parks, H Chen, ... Cell reports 21 (13), 3681-3690, 2017 | 103 | 2017 |
| Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10 Y Chen, J Zhang, KK Hwang, H Bouton-Verville, SM Xia, A Newman, ... The Journal of Immunology 191 (3), 1260-1275, 2013 | 103 | 2013 |
| Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: Selection against membrane proximal external region–associated autoreactivity limits T-dependent responses L Verkoczy, Y Chen, J Zhang, H Bouton-Verville, A Newman, B Lockwood, ... The Journal of Immunology 191 (5), 2538-2550, 2013 | 98 | 2013 |
| Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA … T Mai, H Zan, J Zhang, JS Hawkins, Z Xu, P Casali Journal of Biological Chemistry 285 (48), 37797, 2010 | 92 | 2010 |
| Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations WB Williams, J Zhang, C Jiang, NI Nicely, D Fera, K Luo, MA Moody, ... Nature communications 8 (1), 1732, 2017 | 84 | 2017 |
| cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages WG Feng, YB Wang, JS Zhang, XY Wang, CL Li, ZL Chang Cell research 12 (5), 331-337, 2002 | 77 | 2002 |
| CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra-and intracellular Ca2+ but not PKA, PKC, ERK, or p38 MAPK J Zhou, G Yao, J Zhang, Z Chang Biochemical and biophysical research communications 296 (4), 1013-1018, 2002 | 68 | 2002 |
| NF-κB regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: roles of PKC, PKA, ERK, p38 MAPK, and proteasome JS Zhang, WG Feng, CL Li, XY Wang, ZL Chang Cellular immunology 204 (1), 38-45, 2000 | 61 | 2000 |
| Heat shock response inhibits IL-18 expression through the JNK pathway in murine peritoneal macrophages Y Wang, C Li, X Wang, J Zhang, Z Chang Biochemical and biophysical research communications 296 (3), 742-748, 2002 | 60 | 2002 |
| Expression of toll-like receptors 2 and 4 and CD14 during differentiation of HL-60 cells induced by phorbol 12-myristate 13-acetate and 1α, 25-dihydroxy-vitamin D3 C Li, Y Wang, L Gao, J Zhang, J Shao, S Wang, W Feng, X Wang, M Li, ... | 54 | 2002 |
| Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination H Zan, CA White, LM Thomas, T Mai, G Li, Z Xu, J Zhang, P Casali Cell reports 2 (5), 1220-1232, 2012 | 53 | 2012 |
| Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus … H Zan, J Zhang, S Ardeshna, Z Xu, SR Park, P Casali Autoimmunity 42 (2), 89-103, 2009 | 52 | 2009 |
Laurent VerkoczyProfessor, Applied biomedical Science Institute在 SDBRI.org 的电子邮件经过验证
