| Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation SW Fanning, CG Mayne, V Dharmarajan, KE Carlson, TA Martin, ... elife 5, e12792, 2016 | 294 | 2016 |
| On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex*♦ A Patel, V Dharmarajan, VE Vought, MS Cosgrove Journal of Biological Chemistry 284 (36), 24242-24256, 2009 | 275 | 2009 |
| A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex A Patel, VE Vought, V Dharmarajan, MS Cosgrove Journal of Biological Chemistry 283 (47), 32162-32175, 2008 | 231 | 2008 |
| Structure of the full-length glucagon class B G-protein-coupled receptor H Zhang, A Qiao, D Yang, L Yang, A Dai, C De Graaf, S Reedtz-Runge, ... Nature 546 (7657), 259-264, 2017 | 211 | 2017 |
| Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide A Patel, V Dharmarajan, MS Cosgrove Journal of Biological Chemistry 283 (47), 32158-32161, 2008 | 198 | 2008 |
| Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases V Dharmarajan, JH Lee, A Patel, DG Skalnik, MS Cosgrove Journal of Biological Chemistry 287 (33), 27275-27289, 2012 | 133 | 2012 |
| Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand X Zhang, F Zhao, Y Wu, J Yang, GW Han, S Zhao, A Ishchenko, L Ye, ... Nature communications 8 (1), 15383, 2017 | 119 | 2017 |
| Conformational states of the full-length glucagon receptor L Yang, D Yang, C De Graaf, A Moeller, GM West, V Dharmarajan, ... Nature communications 6 (1), 7859, 2015 | 115 | 2015 |
| A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex A Patel, VE Vought, V Dharmarajan, MS Cosgrove Journal of Biological Chemistry 286 (5), 3359-3369, 2011 | 106 | 2011 |
| HDX-MS guided drug discovery: small molecules and biopharmaceuticals DP Marciano, V Dharmarajan, PR Griffin Current opinion in structural biology 28, 105-111, 2014 | 100 | 2014 |
| The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells SW Fanning, R Jeselsohn, V Dharmarajan, CG Mayne, M Karimi, ... Elife 7, e37161, 2018 | 97 | 2018 |
| Full antagonism of the estrogen receptor without a prototypical ligand side chain S Srinivasan, JC Nwachukwu, NE Bruno, V Dharmarajan, D Goswami, ... Nature chemical biology 13 (1), 111-118, 2017 | 63 | 2017 |
| Synthetic RORγt agonists enhance protective immunity MR Chang, V Dharmarajan, C Doebelin, RD Garcia-Ordonez, SJ Novick, ... ACS chemical biology 11 (4), 1012-1018, 2016 | 53 | 2016 |
| Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling JE Longbotham, CM Chio, V Dharmarajan, MJ Trnka, IO Torres, ... Nature communications 10 (1), 94, 2019 | 48 | 2019 |
| Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1 IMS de Vera, P Munoz-Tello, J Zheng, V Dharmarajan, DP Marciano, ... Structure 27 (1), 66-77. e5, 2019 | 47 | 2019 |
| Identification and function of conformational dynamics in the multidomain GTP ase dynamin S Srinivasan, V Dharmarajan, DK Reed, PR Griffin, SL Schmid The EMBO journal 35 (4), 443-457, 2016 | 46 | 2016 |
| A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase N Shkriabai, V Dharmarajan, A Slaughter, JJ Kessl, RC Larue, L Feng, ... Journal of Biological Chemistry 289 (38), 26430-26440, 2014 | 43 | 2014 |
| The competitive interplay between allosteric HIV-1 integrase inhibitor BI/D and LEDGF/p75 during the early stage of HIV-1 replication adversely affects inhibitor potency L Feng, V Dharmarajan, E Serrao, A Hoyte, RC Larue, A Slaughter, ... ACS chemical biology 11 (5), 1313-1321, 2016 | 42 | 2016 |
| A steric “ball-and-chain” mechanism for pH-mediated regulation of gap junction channels AK Khan, M Jagielnicki, WE McIntire, MD Purdy, V Dharmarajan, ... Cell reports 31 (3), 2020 | 39 | 2020 |
| Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a “two-active site” model for multiple histone H3 lysine 4 methylation A Patel, VE Vought, S Swatkoski, S Viggiano, B Howard, V Dharmarajan, ... Journal of Biological Chemistry 289 (2), 868-884, 2014 | 37 | 2014 |
