| Role of CAR and PXR in xenobiotic sensing and metabolism YM Wang, SS Ong, SC Chai, T Chen Expert opinion on drug metabolism & toxicology 8 (7), 803-817, 2012 | 273 | 2012 |
| Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein− protein interactions JH Lee, Q Zhang, S Jo, SC Chai, M Oh, W Im, H Lu, HS Lim Journal of the American Chemical Society 133 (4), 676-679, 2011 | 159 | 2011 |
| Small-molecule modulators of PXR and CAR SC Chai, MT Cherian, YM Wang, T Chen Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1859 (9 …, 2016 | 104 | 2016 |
| SPA70 is a potent antagonist of human pregnane X receptor W Lin, YM Wang, SC Chai, L Lv, J Zheng, J Wu, Q Zhang, YD Wang, ... Nature communications 8 (1), 1-14, 2017 | 97 | 2017 |
| Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase DC Scott, JT Hammill, J Min, DY Rhee, M Connelly, VO Sviderskiy, ... Nature chemical biology 13 (8), 850-857, 2017 | 97 | 2017 |
| One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase T Ju, RB Goldsmith, SC Chai, MJ Maroney, SS Pochapsky, TC Pochapsky Journal of molecular biology 363 (4), 823-834, 2006 | 87 | 2006 |
| Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1 YM Wang, W Lin, SC Chai, J Wu, SS Ong, EG Schuetz, T Chen Toxicology and applied pharmacology 272 (1), 96-107, 2013 | 79 | 2013 |
| Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase SC Chai, AA Jerkins, JJ Banik, I Shalev, JL Pinkham, PC Uden, ... Journal of Biological Chemistry 280 (11), 9865-9869, 2005 | 79 | 2005 |
| Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs J Min, A Mayasundari, F Keramatnia, B Jonchere, SW Yang, J Jarusiewicz, ... Angewandte Chemie 133 (51), 26867-26874, 2021 | 77 | 2021 |
| Characterization of Metal Binding in the Active Sites of Acireductone Dioxygenase Isoforms from Klebsiella ATCC 8724 SC Chai, T Ju, M Dang, RB Goldsmith, MJ Maroney, TC Pochapsky Biochemistry 47 (8), 2428-2438, 2008 | 74 | 2008 |
| Pregnane X receptor and drug-induced liver injury YM Wang, SC Chai, CT Brewer, T Chen Expert opinion on drug metabolism & toxicology 10 (11), 1521-1532, 2014 | 70 | 2014 |
| Fe (II) is the native cofactor for Escherichia coli methionine aminopeptidase SC Chai, WL Wang, QZ Ye Journal of Biological Chemistry 283 (40), 26879-26885, 2008 | 60 | 2008 |
| A current structural perspective on PXR and CAR in drug metabolism CD Buchman, SC Chai, T Chen Expert opinion on drug metabolism & toxicology 14 (6), 635-647, 2018 | 59 | 2018 |
| Data analysis approaches in high throughput screening AN Goktug, SC Chai, T Chen Drug discovery, 201-226, 2013 | 59 | 2013 |
| Discovery of Inhibitors of Escherichia coli Methionine Aminopeptidase with the Fe(II)-Form Selectivity and Antibacterial Activity WL Wang, SC Chai, M Huang, HZ He, TD Hurley, QZ Ye Journal of medicinal chemistry 51 (19), 6110-6120, 2008 | 57 | 2008 |
| Probes of the catalytic site of cysteine dioxygenase SC Chai, JR Bruyere, MJ Maroney Journal of Biological Chemistry 281 (23), 15774-15779, 2006 | 57 | 2006 |
| Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase JP Lu, SC Chai, QZ Ye Journal of medicinal chemistry 53 (3), 1329-1337, 2010 | 48 | 2010 |
| Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation Q Zhang, H Xiao, SC Chai, QQ Hoang, H Lu Journal of Biological Chemistry 286 (44), 38264-38274, 2011 | 37 | 2011 |
| Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer SC Chai, WC Wright, T Chen Medicinal research reviews 40 (3), 1061-1083, 2020 | 36 | 2020 |
| Small-molecule modulators of the constitutive androstane receptor MT Cherian, SC Chai, T Chen Expert opinion on drug metabolism & toxicology 11 (7), 1099-1114, 2015 | 36 | 2015 |
