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Katherine Chan
Katherine Chan
在 utoronto.ca 的电子邮件经过验证
标题
引用次数
引用次数
年份
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ...
Nature 586 (7827), 120-126, 2020
3162020
Drug-induced mitochondrial toxicity
K Chan, D Truong, N Shangari, PJ O’Brien
Expert opinion on drug metabolism & toxicology 1 (4), 655-669, 2005
2082005
Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies
B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, ...
Cell reports 27 (2), 599-615. e12, 2019
1122019
Human and animal hepatocytes in vitro with extrapolation in vivo
JO Peter, K Chan, PM Silber
Chemico-biological interactions 150 (1), 97-114, 2004
1122004
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
M Aregger, KA Lawson, M Billmann, M Costanzo, AHY Tong, K Chan, ...
Nature metabolism 2 (6), 499-513, 2020
872020
Context-dependent regulation of ferroptosis sensitivity
L Magtanong, GD Mueller, KJ Williams, M Billmann, K Chan, DA Armenta, ...
Cell chemical biology 29 (9), 1409-1418. e6, 2022
752022
Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes
JW Martin, K Chan, SA Mabury, PJ O’Brien
Chemico-biological interactions 177 (3), 196-203, 2009
682009
Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p‐benzoquinone compounds
K Chan, N Jensen, PJ O'Brien
Journal of applied toxicology 28 (5), 608-620, 2008
682008
1191 GS-5816, A second generation HCV NS5A inhibitor with potent antiviral activity, broad genotypic coverage and a high resistance barrier
G Cheng, M Yu, B Peng, YJ Lee, A Trejo-Martin, R Gong, C Bush, A Worth, ...
Journal of hepatology, S484-S485, 2013
632013
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®
JG Taylor, S Zipfel, K Ramey, R Vivian, A Schrier, KK Karki, A Katana, ...
Bioorganic & Medicinal Chemistry Letters 29 (16), 2428-2436, 2019
602019
Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated aldehydes
K Chan, R Poon, PJ O'Brien
Journal of applied toxicology 28 (8), 1027-1039, 2008
562008
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
SA Moquin, O Simon, R Karuna, SB Lakshminarayana, F Yokokawa, ...
Science translational medicine 13 (579), eabb2181, 2021
552021
Structure–activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes
K Chan, NS Jensen, PM Silber, PJ O’Brien
Chemico-Biological Interactions 165 (3), 165-174, 2007
552007
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent
HJ Kwon, W Xing, K Chan, A Niedziela-Majka, KM Brendza, T Kirschberg, ...
PLoS One 10 (4), e0122844, 2015
512015
Identifying cell receptors for the nanoparticle protein corona using genome screens
W Ngo, JLY Wu, ZP Lin, Y Zhang, B Bussin, A Granda Farias, AM Syed, ...
Nature Chemical Biology 18 (9), 1023-1031, 2022
482022
Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated esters, acrylates and methacrylates
K Chan, PJ O'Brien
Journal of applied toxicology 28 (8), 1004-1015, 2008
482008
A cohesin traffic pattern genetically linked to gene regulation
AL Valton, SV Venev, B Mair, ES Khokhar, AHY Tong, M Usaj, K Chan, ...
Nature structural & molecular biology 29 (12), 1239-1251, 2022
422022
Pooled lentiviral CRISPR-Cas9 screens for functional genomics in mammalian cells
M Aregger, M Chandrashekhar, AHY Tong, K Chan, J Moffat
Brain Tumor Stem Cells: Methods and Protocols, 169-188, 2019
412019
Development of robust hepatitis C virus genotype 4 subgenomic replicons
B Peng, M Yu, S Xu, YJ Lee, Y Tian, H Yang, K Chan, H Mo, ...
Gastroenterology 144 (1), 59-61. e6, 2013
412013
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
Y Feng, C Li, JA Stewart, P Barbulescu, N Seija Desivo, A Álvarez-Quilón, ...
Nature 600 (7888), 324-328, 2021
402021
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