Functional genomic landscape of cancer-intrinsic evasion of killing by T cells KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ... Nature 586 (7827), 120-126, 2020 | 316 | 2020 |
Drug-induced mitochondrial toxicity K Chan, D Truong, N Shangari, PJ O’Brien Expert opinion on drug metabolism & toxicology 1 (4), 655-669, 2005 | 208 | 2005 |
Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, ... Cell reports 27 (2), 599-615. e12, 2019 | 112 | 2019 |
Human and animal hepatocytes in vitro with extrapolation in vivo JO Peter, K Chan, PM Silber Chemico-biological interactions 150 (1), 97-114, 2004 | 112 | 2004 |
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism M Aregger, KA Lawson, M Billmann, M Costanzo, AHY Tong, K Chan, ... Nature metabolism 2 (6), 499-513, 2020 | 87 | 2020 |
Context-dependent regulation of ferroptosis sensitivity L Magtanong, GD Mueller, KJ Williams, M Billmann, K Chan, DA Armenta, ... Cell chemical biology 29 (9), 1409-1418. e6, 2022 | 75 | 2022 |
Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes JW Martin, K Chan, SA Mabury, PJ O’Brien Chemico-biological interactions 177 (3), 196-203, 2009 | 68 | 2009 |
Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p‐benzoquinone compounds K Chan, N Jensen, PJ O'Brien Journal of applied toxicology 28 (5), 608-620, 2008 | 68 | 2008 |
1191 GS-5816, A second generation HCV NS5A inhibitor with potent antiviral activity, broad genotypic coverage and a high resistance barrier G Cheng, M Yu, B Peng, YJ Lee, A Trejo-Martin, R Gong, C Bush, A Worth, ... Journal of hepatology, S484-S485, 2013 | 63 | 2013 |
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi® JG Taylor, S Zipfel, K Ramey, R Vivian, A Schrier, KK Karki, A Katana, ... Bioorganic & Medicinal Chemistry Letters 29 (16), 2428-2436, 2019 | 60 | 2019 |
Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated aldehydes K Chan, R Poon, PJ O'Brien Journal of applied toxicology 28 (8), 1027-1039, 2008 | 56 | 2008 |
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models SA Moquin, O Simon, R Karuna, SB Lakshminarayana, F Yokokawa, ... Science translational medicine 13 (579), eabb2181, 2021 | 55 | 2021 |
Structure–activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes K Chan, NS Jensen, PM Silber, PJ O’Brien Chemico-Biological Interactions 165 (3), 165-174, 2007 | 55 | 2007 |
Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent HJ Kwon, W Xing, K Chan, A Niedziela-Majka, KM Brendza, T Kirschberg, ... PLoS One 10 (4), e0122844, 2015 | 51 | 2015 |
Identifying cell receptors for the nanoparticle protein corona using genome screens W Ngo, JLY Wu, ZP Lin, Y Zhang, B Bussin, A Granda Farias, AM Syed, ... Nature Chemical Biology 18 (9), 1023-1031, 2022 | 48 | 2022 |
Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated esters, acrylates and methacrylates K Chan, PJ O'Brien Journal of applied toxicology 28 (8), 1004-1015, 2008 | 48 | 2008 |
A cohesin traffic pattern genetically linked to gene regulation AL Valton, SV Venev, B Mair, ES Khokhar, AHY Tong, M Usaj, K Chan, ... Nature structural & molecular biology 29 (12), 1239-1251, 2022 | 42 | 2022 |
Pooled lentiviral CRISPR-Cas9 screens for functional genomics in mammalian cells M Aregger, M Chandrashekhar, AHY Tong, K Chan, J Moffat Brain Tumor Stem Cells: Methods and Protocols, 169-188, 2019 | 41 | 2019 |
Development of robust hepatitis C virus genotype 4 subgenomic replicons B Peng, M Yu, S Xu, YJ Lee, Y Tian, H Yang, K Chan, H Mo, ... Gastroenterology 144 (1), 59-61. e6, 2013 | 41 | 2013 |
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Y Feng, C Li, JA Stewart, P Barbulescu, N Seija Desivo, A Álvarez-Quilón, ... Nature 600 (7888), 324-328, 2021 | 40 | 2021 |