| Lack of beta-arrestin signaling in the absence of active G proteins M Grundmann, N Merten, D Malfacini, A Inoue, P Preis, K Simon, ... Nature communications 9 (1), 341, 2018 | 401 | 2018 |
| The experimental power of FR900359 to study Gq-regulated biological processes R Schrage, AL Schmitz, E Gaffal, S Annala, S Kehraus, D Wenzel, ... Nature communications 6 (1), 10156, 2015 | 380 | 2015 |
| Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells R Schröder, J Schmidt, S Blättermann, L Peters, N Janssen, ... Nature protocols 6 (11), 1748-1760, 2011 | 210 | 2011 |
| Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases E Christiansen, KR Watterson, CJ Stocker, E Sokol, L Jenkins, K Simon, ... British Journal of Nutrition 113 (11), 1677-1688, 2015 | 134 | 2015 |
| Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ... Journal of Biological Chemistry 286 (12), 10628-10640, 2011 | 130 | 2011 |
| Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties E Christiansen, C Urban, M Grundmann, ME Due-Hansen, ... Journal of medicinal chemistry 54 (19), 6691-6703, 2011 | 91 | 2011 |
| Pharmacology of free fatty acid receptors and their allosteric modulators M Grundmann, E Bender, J Schamberger, F Eitner International journal of molecular sciences 22 (4), 1763, 2021 | 87 | 2021 |
| Temporal bias: time-encoded dynamic GPCR signaling M Grundmann, E Kostenis Trends in pharmacological sciences 38 (12), 1110-1124, 2017 | 87 | 2017 |
| Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs BD Hudson, E Christiansen, IG Tikhonova, M Grundmann, E Kostenis, ... The FASEB Journal 26 (12), 4951, 2012 | 84 | 2012 |
| Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes E Christiansen, SVF Hansen, C Urban, BD Hudson, ET Wargent, ... ACS medicinal chemistry letters 4 (5), 441-445, 2013 | 81 | 2013 |
| Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans R Wagner, G Kaiser, F Gerst, E Christiansen, ME Due-Hansen, ... Diabetes 62 (6), 2106-2111, 2013 | 77 | 2013 |
| Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40 J Schmidt, K Liebscher, N Merten, M Grundmann, M Mielenz, ... Journal of Biological Chemistry 286 (14), 11890-11894, 2011 | 67 | 2011 |
| Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties E Christiansen, ME Due-Hansen, C Urban, M Grundmann, R Schröder, ... Journal of medicinal chemistry 55 (14), 6624-6628, 2012 | 63 | 2012 |
| Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability E Christiansen, ME Due-Hansen, C Urban, M Grundmann, J Schmidt, ... Journal of medicinal chemistry 56 (3), 982-992, 2013 | 62 | 2013 |
| A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation AL Schmitz, R Schrage, E Gaffal, TH Charpentier, J Wiest, ... Chemistry & biology 21 (7), 890-902, 2014 | 60 | 2014 |
| N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators R Blöcher, C Lamers, SK Wittmann, D Merk, M Hartmann, L Weizel, ... Journal of medicinal chemistry 59 (1), 61-81, 2016 | 54 | 2016 |
| WNT stimulation dissociates a Frizzled 4 inactive-state complex with Gα12/13 E Arthofer, B Hot, J Petersen, K Strakova, S Jäger, M Grundmann, ... Molecular pharmacology 90 (4), 447-459, 2016 | 50 | 2016 |
| Direct blood pressure-independent anti-fibrotic effects by the selective nonsteroidal mineralocorticoid receptor antagonist finerenone in progressive models of kidney fibrosis K Droebner, M Pavkovic, M Grundmann, E Hartmann, L Goea, ... American Journal of Nephrology 52 (7), 588-601, 2021 | 45 | 2021 |
| Label-free biosensor assays in GPCR screening M Grundmann, E Kostenis G Protein-Coupled Receptor Screening Assays: Methods and Protocols, 199-213, 2015 | 43 | 2015 |
| A molecular mechanism for sequential activation of a G protein-coupled receptor M Grundmann, IG Tikhonova, BD Hudson, NJ Smith, K Mohr, T Ulven, ... Cell Chemical Biology 23 (3), 392-403, 2016 | 38 | 2016 |
