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Lena Smirnova
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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
A Rybak, H Fuchs, L Smirnova, C Brandt, EE Pohl, R Nitsch, FG Wulczyn
Nature cell biology 10 (8), 987-993, 2008
9982008
Regulation of miRNA expression during neural cell specification
L Smirnova, A Gräfe, A Seiler, S Schumacher, R Nitsch, FG Wulczyn
European Journal of Neuroscience 21 (6), 1469-1477, 2005
8812005
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
A Rybak, H Fuchs, K Hadian, L Smirnova, EA Wulczyn, G Michel, R Nitsch, ...
Nature cell biology 11 (12), 1411-1420, 2009
2942009
Metabolomics in toxicology and preclinical research
T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench, M Coen, ...
Altex 30 (2), 209, 2013
2482013
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
U Marx, T Akabane, TB Andersson, E Baker, M Beilmann, S Beken, ...
Altex 37 (3), 365, 2020
2222020
A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity
D Pamies, P Barrera, K Block, G Makri, A Kumar, D Wiersma, L Smirnova, ...
Altex 34 (3), 362, 2017
2042017
Food for Thought…: Developmental Neurotoxicity–Challenges in the 21st Century and In Vitro Opportunities
L Smirnova, HT Hogberg, M Leist, T Hartung
Altex 31 (2), 129, 2014
1792014
Integrated Testing Strategies (ITS) for safety assessment.
C Rovida, N Alépée, AM Api, DA Basketter, F y Bois, F Caloni, E Corsini, ...
ALTEX-Alternatives to Animal Experimentations 32 (1), 25-40, 2015
1722015
Good cell culture practice for stem cells and stem-cell-derived models
D Pamies, A Bal-Price, A Simeonov, D Tagle, D Allen, D Gerhold, D Yin, ...
1622017
Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2
CK Bullen, HT Hogberg, A Bahadirli-Talbott, WR Bishai, T Hartung, ...
ALTEX-Alternatives to animal experimentation 37 (4), 665-671, 2020
1592020
Animal testing and its alternatives–The most important omics is economics
L Meigs, L Smirnova, C Rovida, M Leist, T Hartung
ALTEX-Alternatives to animal experimentation 35 (3), 275-305, 2018
1572018
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
BZ Schmidt, M Lehmann, S Gutbier, E Nembo, S Noel, L Smirnova, ...
Archives of toxicology 91, 1-33, 2017
1412017
Rotenone exerts developmental neurotoxicity in a human brain spheroid model
D Pamies, K Block, P Lau, L Gribaldo, CA Pardo, P Barreras, L Smirnova, ...
Toxicology and applied pharmacology 354, 101-114, 2018
1272018
A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis
L Smirnova, G Harris, J Delp, M Valadares, D Pamies, HT Hogberg, ...
Archives of toxicology 90, 2725-2743, 2016
1132016
t4 workshop report: pathways of toxicity
A Kleensang, A Maertens, M Rosenberg, S Fitzpatrick, J Lamb, ...
Altex 31 (1), 53, 2014
1092014
Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish
L Smirnova, BS Caffo, DH Gracias, Q Huang, IE Morales Pantoja, B Tang, ...
Frontiers in Science 1, 1017235, 2023
852023
Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery
PEC Leite, MR Pereira, G Harris, D Pamies, LMG Dos Santos, ...
Particle and fibre toxicology 16, 1-20, 2019
802019
Toward a 3D model of human brain development for studying gene/environment interactions
HT Hogberg, J Bressler, KM Christian, G Harris, G Makri, C O'Driscoll, ...
Stem Cell Research & Therapy 4, 1-7, 2013
762013
Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology
C Rovida, T Barton-Maclaren, E Benfenati, F Caloni, PC Chandrasekera, ...
Altex 37 (4), 579, 2020
752020
Cellular resilience
L Smirnova, G Harris, M Leist, T Hartung
702015
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