| Genome-scale CRISPR-Cas9 knockout screening in human cells O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ... Science 343 (6166), 84-87, 2014 | 5892 | 2014 |
| Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi, DA Scott, J Song, ... Cell 160 (6), 1246-1260, 2015 | 1114 | 2015 |
| Engineered CRISPR-Cas9 nuclease with expanded targeting space H Nishimasu, X Shi, S Ishiguro, L Gao, S Hirano, S Okazaki, T Noda, ... Science 361 (6408), 1259-1262, 2018 | 1104 | 2018 |
| Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aortic aneurysms K Satoh, P Nigro, T Matoba, MR O'dell, Z Cui, X Shi, A Mohan, C Yan, ... Nature medicine 15 (6), 649-656, 2009 | 435 | 2009 |
| Autism genes converge on asynchronous development of shared neuron classes B Paulsen, S Velasco, AJ Kedaigle, M Pigoni, G Quadrato, AJ Deo, ... Nature 602 (7896), 268-273, 2022 | 289 | 2022 |
| Cell divisions are required for L1 retrotransposition X Shi, A Seluanov, V Gorbunova Molecular and cellular biology 27 (4), 1264-1270, 2007 | 127 | 2007 |
| Comprehensive comparative analysis of 5′-end RNA-sequencing methods X Adiconis, AL Haber, SK Simmons, A Levy Moonshine, Z Ji, MA Busby, ... Nature methods 15 (7), 505-511, 2018 | 116 | 2018 |
| Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons H Tekin, S Simmons, B Cummings, L Gao, X Adiconis, CC Hession, ... Nature Biomedical Engineering 2 (7), 540-554, 2018 | 97 | 2018 |
| Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia FF Wagner, L Benajiba, AJ Campbell, M Weïwer, JR Sacher, JP Gale, ... Science translational medicine 10 (431), eaam8460, 2018 | 91 | 2018 |
| Neurotensin orchestrates valence assignment in the amygdala H Li, P Namburi, JM Olson, M Borio, ME Lemieux, A Beyeler, GG Calhoon, ... Nature 608 (7923), 586-592, 2022 | 70 | 2022 |
| Inhibitors of glycogen synthase kinase 3 with exquisite kinome-wide selectivity and their functional effects FF Wagner, JA Bishop, JP Gale, X Shi, M Walk, J Ketterman, D Patnaik, ... ACS Chemical Biology 11 (7), 1952-1963, 2016 | 61 | 2016 |
| Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome PK McCamphill, LJ Stoppel, RK Senter, MC Lewis, AJ Heynen, ... Science translational medicine 12 (544), eaam8572, 2020 | 54 | 2020 |
| Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis SY Park, X Shi, J Pang, C Yan, BC Berk Arteriosclerosis, thrombosis, and vascular biology 33 (4), 737-743, 2013 | 46 | 2013 |
| Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons C Lu, X Shi, A Allen, D Baez-Nieto, A Nikish, NE Sanjana, JQ Pan The FASEB Journal 33 (4), 5287, 2019 | 38 | 2019 |
| Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma M Nie, L Du, W Ren, J Joung, X Ye, X Shi, S Ciftci, D Liu, K Wu, F Zhang, ... Cell Death & Disease 12 (5), 419, 2021 | 29 | 2021 |
| G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart J Pang, X Xu, MR Getman, X Shi, SL Belmonte, H Michaloski, A Mohan, ... Journal of molecular and cellular cardiology 51 (5), 769-776, 2011 | 26 | 2011 |
| Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction X Shi, C Lu, A Corman, A Nikish, Y Zhou, RJ Platt, I Iossifov, F Zhang, ... The American Journal of Human Genetics 110 (10), 1750-1768, 2023 | 13 | 2023 |
| The RSK inhibitor BIX02565 limits cardiac ischemia/reperfusion injury X Shi, MM O’Neill, S MacDonnell, PS Brookes, C Yan, BC Berk Journal of cardiovascular pharmacology and therapeutics 21 (2), 177-186, 2016 | 12 | 2016 |
| Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity M Sorek, W Oweis, M Nissim-Rafinia, M Maman, S Simon, CC Hession, ... Genome Biology 22, 1-25, 2021 | 10 | 2021 |
| AN IN VIVO GENOME-SCALE CRISPR SCREEN DEFINES REGULATORS OF METASTASIS S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi CANCER DISCOVERY 5 (5), 461-461, 2015 | 1 | 2015 |
