| IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation F Mercurio, H Zhu, BW Murray, A Shevchenko, BL Bennett, J Li, ... Science 278 (5339), 860-866, 1997 | 2701 | 1997 |
| Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation KM Sakamoto, KB Kim, A Kumagai, F Mercurio, CM Crews, RJ Deshaies Proceedings of the National Academy of Sciences 98 (15), 8554-8559, 2001 | 1944 | 2001 |
| NF‐κB and the link between inflammation and cancer JA DiDonato, F Mercurio, M Karin Immunological reviews 246 (1), 379-400, 2012 | 1732 | 2012 |
| Severe liver degeneration in mice lacking the IκB kinase 2 gene Q Li, DV Antwerp, F Mercurio, KF Lee, IM Verma Science 284 (5412), 321-325, 1999 | 1316 | 1999 |
| Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 A Lin, A Minden, H Martinetto, FX Claret, C Lange-Carter, F Mercurio, ... Science 268 (5208), 286-290, 1995 | 1029 | 1995 |
| Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation J Didonato, F Mercurio, C Rosette, J Wu-Li, H Suyang, S Ghosh, M Karin Molecular and cellular biology 16 (4), 1295-1304, 1996 | 1013 | 1996 |
| Identification of the receptor component of the IκBα–ubiquitin ligase A Yaron, A Hatzubai, M Davis, I Lavon, S Amit, AM Manning, JS Andersen, ... Nature 396 (6711), 590-594, 1998 | 904 | 1998 |
| Multiple signals converging on NF-κB F Mercurio, AM Manning Current opinion in cell biology 11 (2), 226-232, 1999 | 691 | 1999 |
| NF-κB as a primary regulator of the stress response F Mercurio, AM Manning Oncogene 18 (45), 6163-6171, 1999 | 595 | 1999 |
| Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B JA DiDonato, F Mercurio, M Karin Molecular and cellular biology, 1995 | 469 | 1995 |
| IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex F Mercurio, BW Murray, A Shevchenko, BL Bennett, DB Young, JW Li, ... Molecular and cellular biology 19 (2), 1526-1538, 1999 | 456 | 1999 |
| Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes NH Purcell, G Tang, C Yu, F Mercurio, JA DiDonato, A Lin Proceedings of the National Academy of Sciences 98 (12), 6668-6673, 2001 | 417 | 2001 |
| p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. F Mercurio, JA DiDonato, C Rosette, M Karin Genes & development 7 (4), 705-718, 1993 | 399 | 1993 |
| Inhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase A Yaron, H Gonen, I Alkalay, A Hatzubai, S Jung, S Beyth, F Mercurio, ... The EMBO journal 16 (21), 6486-6494, 1997 | 331 | 1997 |
| HTLV-I Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation MJ Yin, LB Christerson, Y Yamamoto, YT Kwak, S Xu, F Mercurio, ... Cell 93 (5), 875-884, 1998 | 317 | 1998 |
| Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway YW Zhang, DM Otterness, GG Chiang, W Xie, YC Liu, F Mercurio, ... Molecular cell 19 (5), 607-618, 2005 | 316 | 2005 |
| Activation of transcription factor NF-κB requires ELKS, an IκB kinase regulatory subunit JLD Sigala, V Bottero, DB Young, A Shevchenko, F Mercurio, IM Verma Science 304 (5679), 1963-1967, 2004 | 303 | 2004 |
| Ubiquitous and lymphocyte‐specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. E Serfling, R Barthelmäs, I Pfeuffer, B Schenk, S Zarius, R Swoboda, ... The EMBO journal 8 (2), 465-473, 1989 | 301 | 1989 |
| Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy Q Chen, W Xie, DJ Kuhn, PM Voorhees, A Lopez-Girona, D Mendy, ... Blood, The Journal of the American Society of Hematology 111 (9), 4690-4699, 2008 | 296 | 2008 |
| Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination X Tang, S Orlicky, Z Lin, A Willems, D Neculai, D Ceccarelli, F Mercurio, ... Cell 129 (6), 1165-1176, 2007 | 259 | 2007 |
