| Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication F Christ, A Voet, A Marchand, S Nicolet, BA Desimmie, D Marchand, ... Nature chemical biology 6 (6), 442-448, 2010 | 544 | 2010 |
| Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication S Emiliani, A Mousnier, K Busschots, M Maroun, B Van Maele, D Tempé, ... Journal of Biological Chemistry 280 (27), 25517-25523, 2005 | 323 | 2005 |
| Transportin-SR2 imports HIV into the nucleus F Christ, W Thys, J De Rijck, R Gijsbers, A Albanese, D Arosio, S Emiliani, ... Current Biology 18 (16), 1192-1202, 2008 | 320 | 2008 |
| Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus L Vandekerckhove, F Christ, B Van Maele, J De Rijck, R Gijsbers, ... Journal of virology 80 (4), 1886-1896, 2006 | 270 | 2006 |
| The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding K Busschots, J Vercammen, S Emiliani, R Benarous, Y Engelborghs, ... Journal of Biological Chemistry 280 (18), 17841-17847, 2005 | 267 | 2005 |
| Cellular co-factors of HIV-1 integration B Van Maele, K Busschots, L Vandekerckhove, F Christ, Z Debyser Trends in biochemical sciences 31 (2), 98-105, 2006 | 264 | 2006 |
| Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization F Christ, S Shaw, J Demeulemeester, BA Desimmie, A Marchand, S Butler, ... Antimicrobial agents and chemotherapy 56 (8), 4365-4374, 2012 | 213 | 2012 |
| Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication J De Rijck, L Vandekerckhove, R Gijsbers, A Hombrouck, J Hendrix, ... Journal of virology 80 (23), 11498-11509, 2006 | 204 | 2006 |
| Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure− activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors S Pasquini, C Mugnaini, C Tintori, M Botta, A Trejos, RK Arvela, M Larhed, ... Journal of medicinal chemistry 51 (16), 5125-5129, 2008 | 184 | 2008 |
| Identification of the LEDGF/p75 binding site in HIV-1 integrase K Busschots, A Voet, M De Maeyer, JC Rain, S Emiliani, R Benarous, ... Journal of molecular biology 365 (5), 1480-1492, 2007 | 178 | 2007 |
| LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions BA Desimmie, R Schrijvers, J Demeulemeester, D Borrenberghs, ... Retrovirology 10 (1), 1-16, 2013 | 169 | 2013 |
| Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV A Hombrouck, J De Rijck, J Hendrix, L Vandekerckhove, A Voet, ... PLoS pathogens 3 (3), e47, 2007 | 162 | 2007 |
| Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 … M Billamboz, F Bailly, ML Barreca, L De Luca, JF Mouscadet, C Calmels, ... Journal of medicinal chemistry 51 (24), 7717-7730, 2008 | 150 | 2008 |
| LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs R Schrijvers, J De Rijck, J Demeulemeester, N Adachi, S Vets, K Ronen, ... PLoS pathogens 8 (3), e1002558, 2012 | 148 | 2012 |
| Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain … M Billamboz, F Bailly, C Lion, N Touati, H Vezin, C Calmels, ML Andréola, ... Journal of medicinal chemistry 54 (6), 1812-1824, 2011 | 144 | 2011 |
| Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity TL Aboye, H Ha, S Majumder, F Christ, Z Debyser, A Shekhtman, ... Journal of medicinal chemistry 55 (23), 10729-10734, 2012 | 142 | 2012 |
| Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75 L De Luca, ML Barreca, S Ferro, F Christ, N Iraci, R Gitto, AM Monforte, ... ChemMedChem 4 (8), 1311-1316, 2009 | 138 | 2009 |
| The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy F Christ, Z Debyser Virology 435 (1), 102-109, 2013 | 136 | 2013 |
| Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ K Bartholomeeusen, F Christ, J Hendrix, JC Rain, S Emiliani, R Benarous, ... Journal of Biological Chemistry 284 (17), 11467-11477, 2009 | 126 | 2009 |
| LEDGIN-mediated inhibition of integrase–LEDGF/p75 interaction reduces reactivation of residual latent HIV LS Vranckx, J Demeulemeester, S Saleh, A Boll, G Vansant, R Schrijvers, ... EBioMedicine 8, 248-264, 2016 | 113 | 2016 |
