Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase DA Ruess, GJ Heynen, KJ Ciecielski, J Ai, A Berninger, D Kabacaoglu, ... Nature medicine 24 (7), 954-960, 2018 | 350 | 2018 |
Evidence for C Cl/C Br⋅⋅⋅ π Interactions as an Important Contribution to Protein–Ligand Binding Affinity H Matter, M Nazaré, S Güssregen, DW Will, H Schreuder, A Bauer, ... Angewandte Chemie International Edition 48 (16), 2911-2916, 2009 | 297 | 2009 |
A flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones M Nazare, C Schneider, A Lindenschmidt, DW Will Angewandte Chemie International Edition 43 (34), 4526-4528, 2004 | 133 | 2004 |
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray … M Nazaré, DW Will, H Matter, H Schreuder, K Ritter, M Urmann, M Essrich, ... Journal of medicinal chemistry 48 (14), 4511-4525, 2005 | 122 | 2005 |
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels M Schewe, H Sun, Ü Mert, A Mackenzie, ACW Pike, F Schulz, ... Science 363 (6429), 875-880, 2019 | 120 | 2019 |
A General and Mild Palladium‐Catalyzed Domino Reaction for the Synthesis of 2H‐Indazoles N Halland, M Nazaré, O R'kyek, J Alonso, M Urmann, A Lindenschmidt Angewandte Chemie International Edition 48 (37), 6879-6882, 2009 | 117 | 2009 |
Pyrazole-derivatives as factor Xa inhibitors M Nazare, V Wehner, DW Will, H Matter US Patent 7,910,606, 2011 | 81 | 2011 |
Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions H Matter, DW Will, M Nazaré, H Schreuder, V Laux, V Wehner Journal of medicinal chemistry 48 (9), 3290-3312, 2005 | 81 | 2005 |
An activatable lanthanide luminescent probe for time‐gated detection of nitroreductase in live bacteria B Brennecke, Q Wang, Q Zhang, HY Hu, M Nazaré Angewandte Chemie International Edition 59 (22), 8512-8516, 2020 | 68 | 2020 |
Oxybenzamide derivatives useful for inhibiting factor Xa or viia M Nazaré, DW Will, A Peyman, H Matter, G Zoller, U Gerlach US Patent 6,953,857, 2005 | 68 | 2005 |
A new highly thyrotropin receptor-selective small-molecule antagonist with potential for the treatment of Graves' orbitopathy P Marcinkowski, I Hoyer, E Specker, J Furkert, C Rutz, ... Thyroid 29 (1), 111-123, 2019 | 64 | 2019 |
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein–ligand complexes M Nazaré, H Matter, DW Will, M Wagner, M Urmann, J Czech, ... Angewandte Chemie International Edition 51 (4), 905-911, 2012 | 64 | 2012 |
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis HY Hu, NH Lim, D Ding-Pfennigdorff, J Saas, KU Wendt, O Ritzeler, ... Bioconjugate Chemistry 26 (3), 383-388, 2015 | 60 | 2015 |
A general and mild domino approach to substituted 1-aminoindoles N Halland, M Nazaré, J Alonso, O R'kyek, A Lindenschmidt Chemical communications 47 (3), 1042-1044, 2011 | 52 | 2011 |
Enantiospecific Synthesis of the (9S, 18R)‐Diastereomer of the Leukocyte Adhesion Inhibitor Cyclamenol A M Nazaré, H Waldmann Chemistry–A European Journal 7 (15), 3363-3376, 2001 | 50 | 2001 |
Synthesis of the (9S,18R) Diastereomer of Cyclamenol A M Nazaré, H Waldmann Angewandte Chemie International Edition 39 (6), 1125-1128, 2000 | 48 | 2000 |
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors N Halland, F Schmidt, T Weiss, J Saas, Z Li, J Czech, M Dreyer, ... ACS medicinal chemistry letters 6 (1), 73-78, 2015 | 47 | 2015 |
N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel … C Boldron, A Besse, MF Bordes, S Tissandié, X Yvon, B Gau, A Badorc, ... Journal of medicinal chemistry 57 (17), 7293-7316, 2014 | 47 | 2014 |
Identification and characterization of a single high‐affinity fatty acid binding site in human serum albumin L Wenskowsky, H Schreuder, V Derdau, H Matter, J Volkmar, M Nazaré, ... Angewandte Chemie 130 (4), 1056-1060, 2018 | 44 | 2018 |
Revealing cytotoxic substructures in molecules using deep learning HE Webel, TB Kimber, S Radetzki, M Neuenschwander, M Nazaré, ... Journal of computer-aided molecular design 34 (7), 731-746, 2020 | 42 | 2020 |