CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, ... Nature biotechnology 31 (9), 833-838, 2013 | 2277 | 2013 |
Next-generation digital information storage in DNA GM Church, Y Gao, S Kosuri Science 337 (6102), 1628-1628, 2012 | 1439 | 2012 |
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription F Zhang, L Cong, S Lodato, S Kosuri, GM Church, P Arlotta Nature biotechnology 29 (2), 149-153, 2011 | 1184 | 2011 |
Large-scale de novo DNA synthesis: technologies and applications S Kosuri, GM Church Nature methods 11 (5), 499-507, 2014 | 971 | 2014 |
Causes and effects of N-terminal codon bias in bacterial genes DB Goodman, GM Church, S Kosuri Science 342 (6157), 475-479, 2013 | 630 | 2013 |
Composability of regulatory sequences controlling transcription and translation in Escherichia coli S Kosuri, DB Goodman, G Cambray, VK Mutalik, Y Gao, AP Arkin, D Endy, ... Proceedings of the National Academy of Sciences 110 (34), 14024-14029, 2013 | 472 | 2013 |
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips S Kosuri, N Eroshenko, EM LeProust, M Super, J Way, JB Li, GM Church Nature biotechnology 28 (12), 1295-1299, 2010 | 443* | 2010 |
Refactoring bacteriophage T7 LY Chan, S Kosuri, D Endy Molecular systems biology 1 (1), 2005.0018, 2005 | 414 | 2005 |
Engineering an allosteric transcription factor to respond to new ligands ND Taylor, AS Garruss, R Moretti, S Chan, MA Arbing, D Cascio, ... Nature methods 13 (2), 177-183, 2016 | 319 | 2016 |
Probing the limits of genetic recoding in essential genes MJ Lajoie, S Kosuri, JA Mosberg, CJ Gregg, D Zhang, GM Church Science 342 (6156), 361-363, 2013 | 170 | 2013 |
Assembly of nucleic acid sequences in emulsions GM Church, RC Terry, S Kosuri, D Zhang US Patent 10,202,628, 2019 | 149 | 2019 |
Multiplexed gene synthesis in emulsions for exploring protein functional landscapes C Plesa, AM Sidore, NB Lubock, D Zhang, S Kosuri Science 359 (6373), 343-347, 2018 | 122 | 2018 |
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning EM Jones, NB Lubock, AJ Venkatakrishnan, J Wang, AM Tseng, JM Paggi, ... Elife 9, e54895, 2020 | 111 | 2020 |
A multiplexed assay for exon recognition reveals that an unappreciated fraction of rare genetic variants cause large-effect splicing disruptions R Cheung, KD Insigne, D Yao, CP Burghard, J Wang, YHE Hsiao, ... Molecular cell 73 (1), 183-194. e8, 2019 | 111 | 2019 |
Metagenomic mining of regulatory elements enables programmable species-selective gene expression NI Johns, ALC Gomes, SS Yim, A Yang, T Blazejewski, CS Smillie, ... Nature methods 15 (5), 323-329, 2018 | 101 | 2018 |
Transcription activator-like effectors F Zhang, L Cong, S Kosuri, GM Church US Patent 9,499,592, 2016 | 97 | 2016 |
Engineered CO2 fixing microorganisms producing carbon-based products of interest DA Berry, DE Robertson, FA Skraly, BD Green, CP Ridley, S Kosuri, ... US Patent 7,981,647, 2011 | 84 | 2011 |
Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically Encoded Multiplexed Reporter Assay in Escherichia coli G Urtecho, AD Tripp, KD Insigne, H Kim, S Kosuri Biochemistry 58 (11), 1539-1551, 2018 | 82 | 2018 |
Highly parallel genome variant engineering with CRISPR–Cas9 MJ Sadhu, JS Bloom, L Day, JJ Siegel, S Kosuri, L Kruglyak Nature genetics 50 (4), 510-514, 2018 | 78 | 2018 |
Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides MT Bonde, S Kosuri, HJ Genee, K Sarup-Lytzen, GM Church, ... ACS synthetic biology 4 (1), 17-22, 2015 | 73 | 2015 |