Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin M Elsner, B Guldbakke, M Tiedge, R Munday, S Lenzen Diabetologia 43, 1528-1533, 2000 | 589 | 2000 |
Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells M Elsner, W Gehrmann, S Lenzen Diabetes 60 (1), 200-208, 2011 | 236 | 2011 |
Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells W Gehrmann, M Elsner, S Lenzen Diabetes, Obesity and Metabolism 12, 149-158, 2010 | 206 | 2010 |
Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan M Elsner, M Tiedge, B Guldbakke, R Munday, S Lenzen Diabetologia 45, 1542-1549, 2002 | 189 | 2002 |
The LEW. 1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus S Lenzen, M Tiedge, M Elsner, S Lortz, H Weiss, A Jörns, G Klöppel, ... Diabetologia 44, 1189-1196, 2001 | 151 | 2001 |
Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells M Elsner, E Gurgul-Convey, S Lenzen Free radical biology and medicine 41 (5), 825-834, 2006 | 121 | 2006 |
Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells KLA Souza, E Gurgul-Convey, M Elsner, S Lenzen Journal of Endocrinology 197 (1), 139-150, 2008 | 112 | 2008 |
Antagonism between saturated and unsaturated fatty acids in ROS mediated lipotoxicity in rat insulin-producing cells W Gehrmann, W Würdemann, T Plötz, A Jörns, S Lenzen, M Elsner Cellular Physiology and Biochemistry 36 (3), 852-865, 2015 | 80 | 2015 |
The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells T Plötz, M Hartmann, S Lenzen, M Elsner Nutrition & metabolism 13, 1-11, 2016 | 77 | 2016 |
Metabolic regulation, activity state, and intracellular binding of glucokinase in insulin-secreting cells. M Tiedge, H Steffeck, M Elsner, S Lenzen Diabetes 48 (3), 514-523, 1999 | 69 | 1999 |
Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells I Mehmeti, S Lortz, M Elsner, S Lenzen Journal of Biological Chemistry 289 (39), 26904-26913, 2014 | 66 | 2014 |
Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction M Elsner, T Terbish, A Jörns, O Naujok, D Wedekind, HJ Hedrich, ... Molecular Therapy 20 (5), 918-926, 2012 | 62 | 2012 |
Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan M Elsner, M Tiedge, S Lenzen Diabetologia 46, 1713-1714, 2003 | 60 | 2003 |
The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells T Plötz, B Krümmel, A Laporte, A Pingitore, SJ Persaud, A Jörns, M Elsner, ... Nutrition & Diabetes 7 (12), 305, 2017 | 54 | 2017 |
A specific fluorescence probe for hydrogen peroxide detection in peroxisomes W Gehrmann, M Elsner Free radical research 45 (5), 501-506, 2011 | 47 | 2011 |
AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells C Krüger, M Waldeck-Weiermair, J Kaynert, T Pokrant, Y Komaragiri, ... Redox biology 43, 101962, 2021 | 43 | 2021 |
Engineering of a glucose-responsive surrogate cell for insulin replacement therapy of experimental insulin-dependent diabetes M Tiedge, M Elsner, NH McClenaghan, HJ Hedrich, D Grube, ... Human gene therapy 11 (3), 403-414, 2000 | 39 | 2000 |
Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus H Weiss, A Bleich, HJ Hedrich, B Kölsch, M Elsner, A Jörns, S Lenzen, ... Mammalian Genome 16, 432-441, 2005 | 32 | 2005 |
Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line NH McClenaghan, M Elsner, M Tiedge, S Lenzen Biochemical and biophysical research communications 242 (2), 262-266, 1998 | 26 | 1998 |
Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan M Elsner, E Gurgul-Convey, S Lenzen Antioxidants & Redox Signaling 10 (4), 691-700, 2008 | 25 | 2008 |