| Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis JE Chipuk, GP McStay, A Bharti, T Kuwana, CJ Clarke, LJ Siskind, ... Cell 148 (5), 988-1000, 2012 | 471 | 2012 |
| Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins LJ Siskind, RN Kolesnick, M Colombini Journal of Biological Chemistry 277 (30), 26796-26803, 2002 | 461 | 2002 |
| The lipids C2-and C16-ceramide form large stable channels: implications for apoptosis LJ Siskind, M Colombini Journal of Biological Chemistry 275 (49), 38640-38644, 2000 | 369 | 2000 |
| Mitochondrial ceramide and the induction of apoptosis LJ Siskind Journal of bioenergetics and biomembranes 37, 143-153, 2005 | 311 | 2005 |
| Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations LJ Siskind, RN Kolesnick, M Colombini Mitochondrion 6 (3), 118-125, 2006 | 282 | 2006 |
| Ceramide starves cells to death by downregulating nutrient transporter proteins GG Guenther, ER Peralta, KR Rosales, SY Wong, LJ Siskind, AL Edinger Proceedings of the National Academy of Sciences 105 (45), 17402-17407, 2008 | 227 | 2008 |
| The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis LJ Siskind, TD Mullen, KR Rosales, CJ Clarke, MJ Hernandez-Corbacho, ... Journal of biological chemistry 285 (16), 11818-11826, 2010 | 159 | 2010 |
| Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels LJ Siskind, L Feinstein, T Yu, JS Davis, D Jones, J Choi, JE Zuckerman, ... Journal of biological chemistry 283 (11), 6622-6630, 2008 | 149 | 2008 |
| Sphingolipids and mitochondrial apoptosis GA Patwardhan, LJ Beverly, LJ Siskind Journal of bioenergetics and biomembranes 48, 153-168, 2016 | 128 | 2016 |
| Repeated administration of low-dose cisplatin in mice induces fibrosis CN Sharp, MA Doll, TV Dupre, PP Shah, M Subathra, D Siow, GE Arteel, ... American Journal of Physiology-Renal Physiology 310 (6), F560-F568, 2016 | 118 | 2016 |
| Enlargement and contracture of C2-ceramide channels LJ Siskind, A Davoody, N Lewin, S Marshall, M Colombini Biophysical journal 85 (3), 1560-1575, 2003 | 111 | 2003 |
| Developing better mouse models to study cisplatin-induced kidney injury CN Sharp, LJ Siskind American Journal of Physiology-Renal Physiology 313 (4), F835-F841, 2017 | 108 | 2017 |
| Sphingosine forms channels in membranes that differ greatly from those formed by ceramide LJ Siskind, S Fluss, M Bui, M Colombini Journal of bioenergetics and biomembranes 37, 227-236, 2005 | 93 | 2005 |
| Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis TK Nowling, AR Mather, T Thiyagarajan, MJ Hernández-Corbacho, ... Journal of the American Society of Nephrology 26 (6), 1402-1413, 2015 | 75 | 2015 |
| Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease CN Sharp, MA Doll, J Megyesi, GB Oropilla, LJ Beverly, LJ Siskind American Journal of Physiology-Renal Physiology 315 (1), F161-F172, 2018 | 73 | 2018 |
| Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells M Subathra, M Korrapati, LA Howell, JM Arthur, JA Shayman, ... American Journal of Physiology-Renal Physiology 309 (3), F204-F215, 2015 | 66 | 2015 |
| Ceramide channels: destabilization by Bcl-xL and role in apoptosis KT Chang, A Anishkin, GA Patwardhan, LJ Beverly, LJ Siskind, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1848 (10), 2374-2384, 2015 | 65 | 2015 |
| BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins LJ Beverly, LA Howell, M Hernandez-Corbacho, L Casson, JE Chipuk, ... Biochemical Journal 452 (1), 111-119, 2013 | 65 | 2013 |
| Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress PP Shah, TV Dupre, LJ Siskind, LJ Beverly Oncotarget 8 (14), 22625, 2017 | 64 | 2017 |
| Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins K Romero Rosales, G Singh, K Wu, J Chen, MR Janes, MB Lilly, ... Biochemical Journal 439 (2), 299-311, 2011 | 58 | 2011 |
