Microtubule dynamics as a target in oncology AL Risinger, FJ Giles, SL Mooberry Cancer treatment reviews 35 (3), 255-261, 2009 | 320 | 2009 |
Eribulin mesylate: mechanism of action of a unique microtubule-targeting agent NF Dybdal-Hargreaves, AL Risinger, SL Mooberry Clinical Cancer Research 21 (11), 2445-2452, 2015 | 222 | 2015 |
The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms AL Risinger, EM Jackson, LA Polin, GL Helms, DA LeBoeuf, PA Joe, ... Cancer research 68 (21), 8881-8888, 2008 | 141 | 2008 |
Design, synthesis, and biological evaluations of 2, 5-diaryl-2, 3-dihydro-1, 3, 4-oxadiazoline analogs of combretastatin-A4 L Lee, LM Robb, M Lee, R Davis, H Mackay, S Chavda, B Babu, ... Journal of medicinal chemistry 53 (1), 325-334, 2010 | 101 | 2010 |
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance A Gangjee, Y Zhao, L Lin, S Raghavan, EG Roberts, AL Risinger, ... Journal of medicinal chemistry 53 (22), 8116-8128, 2010 | 88 | 2010 |
Microtubule-targeting drugs: more than antimitotics R Kaul, AL Risinger, SL Mooberry Journal of natural products 82 (3), 680-685, 2019 | 83 | 2019 |
Activity-dependent reversible inactivation of the general amino acid permease AL Risinger, NE Cain, EJ Chen, CA Kaiser Molecular biology of the cell 17 (10), 4411-4419, 2006 | 74 | 2006 |
Different Ubiquitin Signals Act at the Golgi and Plasma Membrane to Direct GAP1 Trafficking AL Risinger, CA Kaiser Molecular biology of the cell 19 (7), 2962-2972, 2008 | 65 | 2008 |
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site S Matthew, QY Chen, R Ratnayake, CS Fermaintt, D Lucena-Agell, ... Proceedings of the National Academy of Sciences 118 (9), e2021847118, 2021 | 62 | 2021 |
Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity AL Risinger, J Li, MJ Bennett, CC Rohena, J Peng, DC Schriemer, ... Cancer research 73 (22), 6780-6792, 2013 | 61 | 2013 |
Potent taccalonolides, AF and AJ, inform significant structure–activity relationships and tubulin as the binding site of these microtubule stabilizers J Li, AL Risinger, J Peng, Z Chen, L Hu, SL Mooberry Journal of the American Chemical Society 133 (47), 19064-19067, 2011 | 59 | 2011 |
A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells L Du, AL Risinger, JB King, DR Powell, RH Cichewicz Journal of natural products 77 (7), 1753-1757, 2014 | 54 | 2014 |
Identification and biological activities of new taccalonolide microtubule stabilizers J Peng, AL Risinger, GA Fest, EM Jackson, G Helms, LA Polin, ... Journal of medicinal chemistry 54 (17), 6117-6124, 2011 | 50 | 2011 |
Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy PM LoCoco, AL Risinger, HR Smith, TS Chavera, KA Berg, WP Clarke Elife 6, e29626, 2017 | 48 | 2017 |
Taccalonolides: novel microtubule stabilizers with clinical potential AL Risinger, SL Mooberry Cancer letters 291 (1), 14-19, 2010 | 45 | 2010 |
Identification of compounds with efficacy against malaria parasites from common North American plants S Cai, AL Risinger, S Nair, J Peng, TJC Anderson, L Du, DR Powell, ... Journal of natural products 79 (3), 490-498, 2016 | 43 | 2016 |
Breast cancer cell lines exhibit differential sensitivities to microtubule-targeting drugs independent of doubling time AL Risinger, NF Dybdal-Hargreaves, SL Mooberry Anticancer research 35 (11), 5845-5850, 2015 | 43 | 2015 |
The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation AL Risinger, SM Riffle, M Lopus, MA Jordan, L Wilson, SL Mooberry Molecular cancer 13, 1-12, 2014 | 42 | 2014 |
Mapping chromatin structure in vivo using DNA methyltransferases WJ Jessen, A Dhasarathy, SA Hoose, CD Carvin, AL Risinger, MP Kladde Methods 33 (1), 68-80, 2004 | 38 | 2004 |
ELR510444, a novel microtubule disruptor with multiple mechanisms of action AL Risinger, CD Westbrook, A Encinas, M Muelbaier, CM Schultes, ... Journal of Pharmacology and Experimental Therapeutics 336 (3), 652-660, 2011 | 37 | 2011 |