Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ... Nature Biomedical Engineering 5 (6), 600-612, 2021 | 192 | 2021 |
Neutralisation sensitivity of the SARS-CoV-2 omicron (B. 1.1. 529) variant: a cross-sectional study DJ Sheward, C Kim, RA Ehling, A Pankow, XC Dopico, R Dyrdak, ... The Lancet Infectious Diseases 22 (6), 813-820, 2022 | 101* | 2022 |
Evasion of neutralising antibodies by omicron sublineage BA. 2.75 DJ Sheward, C Kim, J Fischbach, S Muschiol, RA Ehling, NK Björkström, ... The Lancet Infectious Diseases 22 (10), 1421-1422, 2022 | 83 | 2022 |
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei, SW Metcalfe, ... Cell 185 (21), 4008-4022. e14, 2022 | 71 | 2022 |
Omicron sublineage BA. 2.75. 2 exhibits extensive escape from neutralising antibodies DJ Sheward, C Kim, J Fischbach, K Sato, S Muschiol, RA Ehling, ... The Lancet Infectious Diseases 22 (11), 1538-1540, 2022 | 69 | 2022 |
A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients F Bieberich, R Vazquez-Lombardi, A Yermanos, RA Ehling, DM Mason, ... Frontiers in immunology 12, 701085, 2021 | 41 | 2021 |
High efficiency gene correction in hematopoietic cells by donor-template-free CRISPR/Cas9 genome editing D Sürün, J Schwäble, A Tomasovic, R Ehling, S Stein, N Kurrle, ... Molecular Therapy-Nucleic Acids 10, 1-8, 2018 | 41 | 2018 |
Molecular design, optimization, and genomic integration of chimeric B cell receptors in murine B cells T Pesch, L Bonati, W Kelton, C Parola, RA Ehling, L Csepregi, D Kitamura, ... Frontiers in immunology 10, 2630, 2019 | 26 | 2019 |
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells D Neumeier, A Yermanos, A Agrafiotis, L Csepregi, T Chowdhury, ... Proceedings of the National Academy of Sciences 119 (18), e2113766119, 2022 | 20 | 2022 |
SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display RA Ehling, CR Weber, DM Mason, S Friedensohn, B Wagner, F Bieberich, ... Cell reports 38 (3), 2022 | 20* | 2022 |
Immune literacy: reading, writing, and editing adaptive immunity L Csepregi, RA Ehling, B Wagner, ST Reddy Iscience 23 (9), 2020 | 18 | 2020 |
Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity D Shlesinger, KL Hong, G Shammas, N Page, I Sandu, A Agrafiotis, ... Genes & Immunity 23 (6), 183-195, 2022 | 14 | 2022 |
Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single‐cell analysis D Neumeier, A Pedrioli, A Genovese, I Sandu, R Ehling, KL Hong, ... European journal of immunology 52 (2), 297-311, 2022 | 11 | 2022 |
Bjö rkströ m DJ Sheward, C Kim, J Fischbach, S Muschiol, RA Ehling NK, Karlsson Hedestam, GB, Reddy, ST, Albert, J., Peacock, TP, and Murrell …, 2022 | 7 | 2022 |
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning. Nat Biomed Eng. 2021; 5 (6): 600–12 DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ... | 7 | |
DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2 A Yermanos, KL Hong, A Agrafiotis, J Han, S Nadeau, C Valenzuela, ... BMC genomics 23 (1), 289, 2022 | 5 | 2022 |
Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity A Agrafiotis, D Neumeier, KL Hong, T Chowdhury, R Ehling, R Kuhn, ... Iscience 26 (3), 2023 | 4 | 2023 |
Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS A Agrafiotis, R Dizerens, I Vincenti, I Wagner, R Kuhn, D Shlesinger, ... Acta Neuropathologica 145 (3), 335-355, 2023 | 4 | 2023 |
B cell clonal expansion is correlated with antigen-specificity in young but not old mice A Agrafiotis, D Neumeier, KL Hong, T Chowdhury, R Ehling, R Kuhn, ... BioRxiv, 2021 | 4 | 2021 |
Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2 RA Ehling, M Minot, MD Overath, DJ Sheward, J Han, B Gao, JM Taft, ... bioRxiv, 2024.03. 28.587189, 2024 | 1 | 2024 |