关注
Roy Alexander Ehling
Roy Alexander Ehling
Ex-ETH DBSSE / now Engimmune
在 engimmune.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning
DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ...
Nature Biomedical Engineering 5 (6), 600-612, 2021
1922021
Neutralisation sensitivity of the SARS-CoV-2 omicron (B. 1.1. 529) variant: a cross-sectional study
DJ Sheward, C Kim, RA Ehling, A Pankow, XC Dopico, R Dyrdak, ...
The Lancet Infectious Diseases 22 (6), 813-820, 2022
101*2022
Evasion of neutralising antibodies by omicron sublineage BA. 2.75
DJ Sheward, C Kim, J Fischbach, S Muschiol, RA Ehling, NK Björkström, ...
The Lancet Infectious Diseases 22 (10), 1421-1422, 2022
832022
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain
JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei, SW Metcalfe, ...
Cell 185 (21), 4008-4022. e14, 2022
712022
Omicron sublineage BA. 2.75. 2 exhibits extensive escape from neutralising antibodies
DJ Sheward, C Kim, J Fischbach, K Sato, S Muschiol, RA Ehling, ...
The Lancet Infectious Diseases 22 (11), 1538-1540, 2022
692022
A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
F Bieberich, R Vazquez-Lombardi, A Yermanos, RA Ehling, DM Mason, ...
Frontiers in immunology 12, 701085, 2021
412021
High efficiency gene correction in hematopoietic cells by donor-template-free CRISPR/Cas9 genome editing
D Sürün, J Schwäble, A Tomasovic, R Ehling, S Stein, N Kurrle, ...
Molecular Therapy-Nucleic Acids 10, 1-8, 2018
412018
Molecular design, optimization, and genomic integration of chimeric B cell receptors in murine B cells
T Pesch, L Bonati, W Kelton, C Parola, RA Ehling, L Csepregi, D Kitamura, ...
Frontiers in immunology 10, 2630, 2019
262019
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
D Neumeier, A Yermanos, A Agrafiotis, L Csepregi, T Chowdhury, ...
Proceedings of the National Academy of Sciences 119 (18), e2113766119, 2022
202022
SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display
RA Ehling, CR Weber, DM Mason, S Friedensohn, B Wagner, F Bieberich, ...
Cell reports 38 (3), 2022
20*2022
Immune literacy: reading, writing, and editing adaptive immunity
L Csepregi, RA Ehling, B Wagner, ST Reddy
Iscience 23 (9), 2020
182020
Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity
D Shlesinger, KL Hong, G Shammas, N Page, I Sandu, A Agrafiotis, ...
Genes & Immunity 23 (6), 183-195, 2022
142022
Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single‐cell analysis
D Neumeier, A Pedrioli, A Genovese, I Sandu, R Ehling, KL Hong, ...
European journal of immunology 52 (2), 297-311, 2022
112022
Bjö rkströ m
DJ Sheward, C Kim, J Fischbach, S Muschiol, RA Ehling
NK, Karlsson Hedestam, GB, Reddy, ST, Albert, J., Peacock, TP, and Murrell …, 2022
72022
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning. Nat Biomed Eng. 2021; 5 (6): 600–12
DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ...
7
DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2
A Yermanos, KL Hong, A Agrafiotis, J Han, S Nadeau, C Valenzuela, ...
BMC genomics 23 (1), 289, 2022
52022
Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity
A Agrafiotis, D Neumeier, KL Hong, T Chowdhury, R Ehling, R Kuhn, ...
Iscience 26 (3), 2023
42023
Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS
A Agrafiotis, R Dizerens, I Vincenti, I Wagner, R Kuhn, D Shlesinger, ...
Acta Neuropathologica 145 (3), 335-355, 2023
42023
B cell clonal expansion is correlated with antigen-specificity in young but not old mice
A Agrafiotis, D Neumeier, KL Hong, T Chowdhury, R Ehling, R Kuhn, ...
BioRxiv, 2021
42021
Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2
RA Ehling, M Minot, MD Overath, DJ Sheward, J Han, B Gao, JM Taft, ...
bioRxiv, 2024.03. 28.587189, 2024
12024
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