Dynamic gene regulatory networks drive hematopoietic specification and differentiation DK Goode, N Obier, MS Vijayabaskar, M Lie-A-Ling, AJ Lilly, R Hannah, ... Developmental cell 36 (5), 572-587, 2016 | 230 | 2016 |
Depletion of RUNX1/ETO in t (8; 21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding A Ptasinska, SA Assi, D Mannari, SR James, D Williamson, J Dunne, ... Leukemia 26 (8), 1829-1841, 2012 | 206 | 2012 |
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis M Lichtinger, R Ingram, R Hannah, D Müller, D Clarke, SA Assi, ... The EMBO journal 31 (22), 4318-4333, 2012 | 195 | 2012 |
Subtype-specific regulatory network rewiring in acute myeloid leukemia SA Assi, MR Imperato, DJL Coleman, A Pickin, S Potluri, A Ptasinska, ... Nature genetics 51 (1), 151-162, 2019 | 174 | 2019 |
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells M Leddin, C Perrod, M Hoogenkamp, S Ghani, S Assi, S Heinz, ... Blood, The Journal of the American Society of Hematology 117 (10), 2827-2838, 2011 | 146 | 2011 |
Identification of a dynamic core transcriptional network in t (8; 21) AML that regulates differentiation block and self-renewal A Ptasinska, SA Assi, N Martinez-Soria, MR Imperato, J Piper, P Cauchy, ... Cell reports 8 (6), 1974-1988, 2014 | 145 | 2014 |
Instructive role of MLL-fusion proteins revealed by a model of t (4; 11) pro-B acute lymphoblastic leukemia S Lin, RT Luo, A Ptasinska, J Kerry, SA Assi, M Wunderlich, T Imamura, ... Cancer cell 30 (5), 737-749, 2016 | 112 | 2016 |
The oncogenic transcription factor RUNX1/ETO corrupts cell cycle regulation to drive leukemic transformation N Martinez-Soria, L McKenzie, J Draper, A Ptasinska, H Issa, S Potluri, ... Cancer Cell 34 (4), 626-642. e8, 2018 | 99 | 2018 |
PCRPi: Presaging Critical Residues in Protein interfaces, a new computational tool to chart hot spots in protein interfaces SA Assi, T Tanaka, TH Rabbitts, N Fernandez-Fuentes Nucleic acids research 38 (6), e86-e86, 2010 | 84 | 2010 |
Chronic FLT3-ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature P Cauchy, SR James, J Zacarias-Cabeza, A Ptasinska, MR Imperato, ... Cell reports 12 (5), 821-836, 2015 | 78 | 2015 |
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification J Gilmour, SA Assi, U Jaegle, D Kulu, H van de Werken, D Clarke, ... Development 141 (12), 2391-2401, 2014 | 70 | 2014 |
UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO S Goyama, J Schibler, A Gasilina, M Shrestha, S Lin, KA Link, J Chen, ... Leukemia 30 (3), 728-739, 2016 | 65 | 2016 |
RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t (8; 21) and t (3; 21) AML J Loke, SA Assi, MR Imperato, A Ptasinska, P Cauchy, Y Grabovska, ... Cell reports 19 (8), 1654-1668, 2017 | 56 | 2017 |
Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate N Obier, P Cauchy, SA Assi, J Gilmour, M Lie-A-Ling, M Lichtinger, ... Development 143 (23), 4324-4340, 2016 | 56 | 2016 |
Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors J Piper, SA Assi, P Cauchy, C Ladroue, PN Cockerill, C Bonifer, S Ott BMC genomics 16, 1-8, 2015 | 50 | 2015 |
A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program S Lin, A Ptasinska, X Chen, M Shrestha, SA Assi, PS Chin, MR Imperato, ... Blood, The Journal of the American Society of Hematology 130 (10), 1213-1222, 2017 | 43 | 2017 |
Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia R Tirtakusuma, K Szoltysek, P Milne, VV Grinev, A Ptasinska, PS Chin, ... Blood, The Journal of the American Society of Hematology 140 (17), 1875-1890, 2022 | 39 | 2022 |
RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia VV Grinev, F Barneh, IM Ilyushonak, S Nakjang, J Smink, A van Oort, ... Nature communications 12 (1), 520, 2021 | 39 | 2021 |
RUNX1-ETO depletion in t (8; 21) AML leads to C/EBPα-and AP-1-mediated alterations in enhancer-promoter interaction A Ptasinska, A Pickin, SA Assi, PS Chin, L Ames, R Avellino, S Gröschel, ... Cell reports 28 (12), 3022-3031. e7, 2019 | 35 | 2019 |
Presaging Critical Residues in Protein interfaces-Web Server (PCRPi-W): A Web Server to Chart Hot Spots in Protein Interfaces J Segura Mora, SA Assi, N Fernandez-Fuentes PloS one 5 (8), e12352, 2010 | 34 | 2010 |