| The chemical evolution of oligonucleotide therapies of clinical utility A Khvorova, JK Watts Nature biotechnology 35 (3), 238-248, 2017 | 1043 | 2017 |
| Chemically modified siRNA: tools and applications JK Watts, GF Deleavey, MJ Damha Drug discovery today 13 (19-20), 842-855, 2008 | 553 | 2008 |
| Silencing disease genes in the laboratory and the clinic JK Watts, DR Corey The Journal of pathology 226 (2), 365-379, 2012 | 539* | 2012 |
| Enhancer RNA facilitates NELF release from immediate early genes K Schaukowitch, JY Joo, X Liu, JK Watts, C Martinez, TK Kim Molecular cell 56 (1), 29-42, 2014 | 450 | 2014 |
| RNA therapeutics on the rise F Wang, T Zuroske, JK Watts Nature Reviews Drug Discovery 19, 441-442, 2020 | 214 | 2020 |
| Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing GF Deleavey, JK Watts, T Alain, F Robert, A Kalota, V Aishwarya, ... Nucleic acids research 38 (13), 4547-4557, 2010 | 122 | 2010 |
| Oligonucleotide therapeutics: chemistry, delivery and clinical progress VK Sharma, JK Watts Future medicinal chemistry 7 (16), 2221-2242, 2015 | 114 | 2015 |
| Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide H Tran, MP Moazami, H Yang, D McKenna-Yasek, CL Douthwright, ... Nature medicine 28 (1), 117-124, 2022 | 110 | 2022 |
| Energetically important C− H··· F− C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity MY Anzahaee, JK Watts, NR Alla, AW Nicholson, MJ Damha Journal of the American Chemical Society 133 (4), 728-731, 2011 | 108 | 2011 |
| 2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity JK Watts, N Choubdar, K Sadalapure, F Robert, AS Wahba, J Pelletier, ... Nucleic acids research 35 (5), 1441-1451, 2007 | 108 | 2007 |
| The NIH somatic cell genome editing program K Saha, EJ Sontheimer, PJ Brooks, MR Dwinell, CA Gersbach, DR Liu, ... Nature 592 (7853), 195-204, 2021 | 102 | 2021 |
| Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing A Mir, JF Alterman, MR Hassler, AJ Debacker, E Hudgens, D Echeverria, ... Nature Communications 9, 2641, 2018 | 101 | 2018 |
| Chemical modification of siRNA GF Deleavey, JK Watts, MJ Damha Current Protocols in Nucleic Acid Chemistry 39 (1), 16.3. 1-16.3. 22, 2009 | 91 | 2009 |
| Differential stability of 2′ F-ANA• RNA and ANA• RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility JK Watts, N Martín-Pintado, I Gomez-Pinto, J Schwartzentruber, G Portella, ... Nucleic acids research 38 (7), 2498-2511, 2010 | 90 | 2010 |
| Clinical status of duplex RNA JK Watts, DR Corey Bioorganic & medicinal chemistry letters 20 (11), 3203-3207, 2010 | 89 | 2010 |
| Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles A Poma, H Brahmbhatt, HM Pendergraff, JK Watts, NW Turner Wiley, 2015 | 86 | 2015 |
| 2′ F-Arabinonucleic acids (2′ F-ANA)—History, properties, and new frontiers JK Watts, MJ Damha Canadian Journal of Chemistry 86 (7), 641-656, 2008 | 79 | 2008 |
| Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′ F-ANA) JK Watts, A Katolik, J Viladoms, MJ Damha Organic & biomolecular chemistry 7 (9), 1904-1910, 2009 | 74 | 2009 |
| Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs J Hu, KT Gagnon, J Liu, JK Watts, J Syeda-Nawaz, CF Bennett, ... Walter de Gruyter 392 (4), 315-325, 2011 | 69 | 2011 |
| Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy J Hu, Z Rong, X Gong, Z Zhou, VK Sharma, C Xing, JK Watts, DR Corey, ... Human molecular genetics 27 (6), 1015-1026, 2018 | 67 | 2018 |
Masad J. DamhaDistinguished James McGill Professor在 mcgill.ca 的电子邮件经过验证
