The mutational constraint spectrum quantified from variation in 141,456 humans KJ Karczewski, LC Francioli, G Tiao, BB Cummings, J Alföldi, Q Wang, ... Nature 581 (7809), 434-443, 2020 | 8522* | 2020 |
Biological insights from 108 schizophrenia-associated genetic loci C Pantelis, GN Papadimitriou, S Papiol, E Parkhomenko, MT Pato, ... Nature 511 (7510), 421-427, 2014 | 7382 | 2014 |
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke, J Yang, ... Nature genetics 47 (3), 291-295, 2015 | 4531 | 2015 |
An anatomically comprehensive atlas of the adult human brain transcriptome MJ Hawrylycz, ES Lein, AL Guillozet-Bongaarts, EH Shen, L Ng, JA Miller, ... Nature 489 (7416), 391-399, 2012 | 2800 | 2012 |
Schizophrenia risk from complex variation of complement component 4 A Sekar, AR Bialas, H De Rivera, A Davis, TR Hammond, N Kamitaki, ... Nature 530 (7589), 177-183, 2016 | 2378 | 2016 |
Partitioning heritability by functional annotation using genome-wide association summary statistics HK Finucane, B Bulik-Sullivan, A Gusev, G Trynka, Y Reshef, PR Loh, ... Nature genetics 47 (11), 1228-1235, 2015 | 2257 | 2015 |
Genome-wide association study identifies five new schizophrenia loci Nature genetics 43 (10), 969-976, 2011 | 2016 | 2011 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia V Trubetskoy, AF Pardiñas, T Qi, G Panagiotaropoulou, S Awasthi, ... Nature 604 (7906), 502-508, 2022 | 1665* | 2022 |
Modeling linkage disequilibrium increases accuracy of polygenic risk scores BJ Vilhjálmsson, J Yang, HK Finucane, A Gusev, S Lindström, S Ripke, ... The american journal of human genetics 97 (4), 576-592, 2015 | 1366 | 2015 |
Identification of loci associated with schizophrenia by genome-wide association and follow-up MC O'donovan, N Craddock, N Norton, H Williams, T Peirce, V Moskvina, ... Nature genetics 40 (9), 1053-1055, 2008 | 1314 | 2008 |
Analysis of microarray data using Z score transformation C Cheadle, MP Vawter, WJ Freed, KG Becker The Journal of molecular diagnostics 5 (2), 73-81, 2003 | 1136 | 2003 |
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders PH Lee, V Anttila, H Won, YCA Feng, J Rosenthal, Z Zhu, EM Tucker-Drob, ... Cell 179 (7), 1469-1482. e11, 2019 | 1086 | 2019 |
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects CR Marshall, DP Howrigan, D Merico, B Thiruvahindrapuram, W Wu, ... Nature genetics 49 (1), 27-35, 2017 | 952 | 2017 |
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology N Mullins, AJ Forstner, KS O’Connell, B Coombes, JRI Coleman, Z Qiao, ... Nature genetics 53 (6), 817-829, 2021 | 896 | 2021 |
A structural variation reference for medical and population genetics RL Collins, H Brand, KJ Karczewski, X Zhao, J Alföldi, LC Francioli, ... Nature 581 (7809), 444-451, 2020 | 822* | 2020 |
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder AE Baum, N Akula, M Cabanero, I Cardona, W Corona, B Klemens, ... Molecular psychiatry 13 (2), 197-207, 2008 | 820 | 2008 |
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression PV Choudary, M Molnar, SJ Evans, H Tomita, JZ Li, MP Vawter, RM Myers, ... Proceedings of the National Academy of Sciences 102 (43), 15653-15658, 2005 | 774 | 2005 |
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs SH Lee, TR DeCandia, S Ripke, J Yang, ... Nature genetics 44 (3), 247-250, 2012 | 675 | 2012 |
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder JZ Li, BG Bunney, F Meng, MH Hagenauer, DM Walsh, MP Vawter, ... Proceedings of the National Academy of Sciences 110 (24), 9950-9955, 2013 | 615 | 2013 |
Rare coding variants in ten genes confer substantial risk for schizophrenia T Singh, T Poterba, D Curtis, H Akil, M Al Eissa, JD Barchas, N Bass, ... Nature 604 (7906), 509-516, 2022 | 590* | 2022 |