VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes L Glover, S Hutchinson, S Alsford, D Horn Proceedings of the National Academy of Sciences 113 (26), 7225-7230, 2016 | 106 | 2016 |
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control L Glover, S Hutchinson, S Alsford, R McCulloch, MC Field, D Horn Cellular microbiology 15 (12), 1984-1993, 2013 | 76 | 2013 |
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex J Faria, L Glover, S Hutchinson, C Boehm, MC Field, D Horn Nature communications 10 (1), 3023, 2019 | 68 | 2019 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling JA Thomas, N Baker, S Hutchinson, C Dominicus, A Trenaman, L Glover, ... PLoS neglected tropical diseases 12 (11), e0006980, 2018 | 63 | 2018 |
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes L Glover, S Alsford, N Baker, DJ Turner, A Sanchez-Flores, S Hutchinson, ... Nature protocols 10 (1), 106-133, 2015 | 60 | 2015 |
Biallelic mutations in LRRC56, encoding a protein associated with intraflagellar transport, cause mucociliary clearance and laterality defects S Bonnefoy, CM Watson, KD Kernohan, M Lemos, S Hutchinson, ... The American Journal of Human Genetics 103 (5), 727-739, 2018 | 59 | 2018 |
CRISPR in parasitology: not exactly cut and dried! JM Bryant, S Baumgarten, L Glover, S Hutchinson, N Rachidi Trends in parasitology 35 (6), 409-422, 2019 | 57 | 2019 |
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes J Faria, V Luzak, LSM Müller, BG Brink, S Hutchinson, L Glover, D Horn, ... Nature microbiology 6 (3), 289-300, 2021 | 55 | 2021 |
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes N Baker, G Hamilton, JM Wilkes, S Hutchinson, MP Barrett, D Horn Proceedings of the National Academy of Sciences 112 (29), 9112-9117, 2015 | 52 | 2015 |
The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands S Hutchinson, S Foulon, A Crouzols, R Menafra, B Rotureau, AD Griffiths, ... PLoS pathogens 17 (9), e1009904, 2021 | 34 | 2021 |
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles N Zhang, M Zoltner, KF Leung, P Scullion, S Hutchinson, RC Del Pino, ... Plos Pathogens 14 (2), e1006850, 2018 | 33 | 2018 |
High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes S Hutchinson, L Glover, D Horn BMC Genomics, 2016 | 33 | 2016 |
Escaping the immune system by DNA repair and recombination in African trypanosomes N Sima, EJ McLaughlin, S Hutchinson, L Glover Open biology 9 (11), 190182, 2019 | 25 | 2019 |
Chemogenomic profiling of antileishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei CF Collett, C Kitson, N Baker, HB Steele-Stallard, MV Santrot, ... Antimicrobial Agents and Chemotherapy 63 (8), 10.1128/aac. 00795-19, 2019 | 21 | 2019 |
A post-transcriptional respiratome regulon in trypanosomes A Trenaman, L Glover, S Hutchinson, D Horn Nucleic Acids Research 47 (13), 7063-7077, 2019 | 15 | 2019 |
Flagellar incorporation of proteins follows at least two different routes in trypanosomes L Vincensini, T Blisnick, E Bertiaux, S Hutchinson, C Georgikou, CP Ooi, ... Biology of the Cell 110 (2), 33-47, 2018 | 12 | 2018 |
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes AK Mehnert, M Prorocic, A Dujeancourt-Henry, S Hutchinson, ... Nucleic acids research 49 (3), 1436-1454, 2021 | 11 | 2021 |
Mex67 paralogs mediate division of labor in trypanosome RNA processing and export SO Obado, M Stein, E Hegedűsová, W Zhang, S Hutchinson, M Brillantes, ... bioRxiv, 2022.06. 27.497849, 2022 | 6 | 2022 |
Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes J Faria, V Luzak, LSM Müller, BG Brink, S Hutchinson, L Glover, D Horn, ... bioRxiv, 2020.01. 27.921452, 2020 | 4 | 2020 |
Development of a generalisable tryptophan-optimised quenchbody biosensor based on a synthetic nanobody library JH Cater, N Elsalamouny, GH Mansour, S Hutchinson, C Mc Guinness, ... bioRxiv, 2024.03. 27.582625, 2024 | 1 | 2024 |