关注
Mark Bunnage
Mark Bunnage
Senior Vice President & Head of Research, Vertex
在 vrtx.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8382015
Target validation using chemical probes
ME Bunnage, ELP Chekler, LH Jones
Nature chemical biology 9 (4), 195-199, 2013
4552013
Getting pharmaceutical R&D back on target
ME Bunnage
Nature chemical biology 7 (6), 335-339, 2011
3722011
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
3322014
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains
S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ...
Cancer research 73 (11), 3336-3346, 2013
2922013
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
2542012
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
1862014
Applications of chemogenomic library screening in drug discovery
LH Jones, ME Bunnage
Nature reviews Drug discovery 16 (4), 285-296, 2017
1852017
Total synthesis of balanol
KC Nicolaou, ME Bunnage, K Koide
Journal of the American Chemical Society 116 (18), 8402-8403, 1994
1481994
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
O Fedorov, J Castex, C Tallant, DR Owen, S Martin, M Aldeghi, ...
Science advances 1 (10), e1500723, 2015
1422015
Fluorine in drug design: a case study with fluoroanisoles
L Xing, DC Blakemore, A Narayanan, R Unwalla, F Lovering, RA Denny, ...
ChemMedChem 10 (4), 715-726, 2015
1372015
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase
N Narayana, TC Diller, K Koide, ME Bunnage, KC Nicolaou, LL Brunton, ...
Biochemistry 38 (8), 2367-2376, 1999
1341999
Total synthesis of brevetoxin A: Part 1: First generation strategy and construction of BCD ring system
KC Nicolaou, ME Bunnage, DG McGarry, S Shi, PK Somers, PA Wallace, ...
Chemistry–A European Journal 5 (2), 599-617, 1999
1271999
Know your target, know your molecule
ME Bunnage, AM Gilbert, LH Jones, EC Hett
Nature chemical biology 11 (6), 368-372, 2015
1152015
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease
DS Millan, ME Bunnage, JL Burrows, KJ Butcher, PG Dodd, TJ Evans, ...
Journal of medicinal chemistry 54 (22), 7797-7814, 2011
1112011
Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′, 5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction
ME Bunnage, JP Mathias, SDA Street, A Wood
US Patent 6,916,927, 2005
1112005
Total synthesis of brevetoxin A: Part 2: Second generation strategy and construction of EFGH model system
KC Nicolaou, PA Wallace, S Shi, MA Ouellette, ME Bunnage, JL Gunzner, ...
Chemistry–A European Journal 5 (2), 618-627, 1999
1011999
Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit
BS Gerstenberger, JD Trzupek, C Tallant, O Fedorov, P Filippakopoulos, ...
Journal of medicinal chemistry 59 (10), 4800-4811, 2016
982016
An expeditious asymmetric synthesis of allophenylnorstatine
ME Bunnage, SG Davies, CJ Goodwin, O Ichihara
Tetrahedron 50 (13), 3975-3986, 1994
97*1994
Donated chemical probes for open science
S Müller, S Ackloo, CH Arrowsmith, M Bauser, JL Baryza, J Blagg, ...
elife 7, e34311, 2018
942018
系统目前无法执行此操作,请稍后再试。
文章 1–20