Upgrading aminoacyl-tRNA synthetases for genetic code expansion O Vargas-Rodriguez, A Sevostyanova, D Söll, A Crnković Current opinion in chemical biology 46, 115-122, 2018 | 111 | 2018 |
Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli MG Napolitano, M Landon, CJ Gregg, MJ Lajoie, L Govindarajan, ... Proceedings of the National Academy of Sciences 113 (38), E5588-E5597, 2016 | 74 | 2016 |
Exclusive use of trans-editing domains prevents proline mistranslation O Vargas-Rodriguez, K Musier-Forsyth Journal of Biological Chemistry 288 (20), 14391-14399, 2013 | 54 | 2013 |
Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid Y Song, H Zhou, MN Vo, Y Shi, MH Nawaz, O Vargas-Rodriguez, ... Nature Communications 8 (1), 2281, 2017 | 46 | 2017 |
Genetic encoding of three distinct noncanonical amino acids using reprogrammed initiator and nonsense codons JM Tharp, O Vargas-Rodriguez, A Schepartz, D Soll ACS chemical biology 16 (4), 766-774, 2021 | 44 | 2021 |
Engineering posttranslational proofreading to discriminate nonstandard amino acids AM Kunjapur, DA Stork, E Kuru, O Vargas-Rodriguez, M Landon, D Söll, ... Proceedings of the National Academy of Sciences 115 (3), 619-624, 2018 | 43 | 2018 |
Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation Z Liu*, O Vargas-Rodriguez*, Y Goto, EM Novoa, L Ribas de Pouplana, ... Proceedings of the National Academy of Sciences 112 (19), 6027-6032, 2015 | 43 | 2015 |
Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation M Das*, O Vargas-Rodriguez*, Y Goto, H Suga, K Musier-Forsyth Nucleic acids research 42 (6), 3943-3953, 2014 | 42 | 2014 |
Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site SV Melnikov, NF Khabibullina, E Mairhofer, O Vargas-Rodriguez, ... Nucleic Acids Research 47 (4), 2089-2100, 2019 | 36 | 2019 |
Transfer RNAs with novel cloverleaf structures T Mukai, O Vargas-Rodriguez, M Englert, HJ Tripp, NN Ivanova, ... Nucleic Acids Research 45 (5), 2776-2785, 2017 | 35 | 2017 |
The central role of tRNA in genetic code expansion NM Reynolds, O Vargas-Rodriguez, D Söll, A Crnković Biochimica et Biophysica Acta (BBA)-General Subjects 1861 (11), 3001-3008, 2017 | 34 | 2017 |
Ancestral AlaX editing enzymes for control of genetic code fidelity are not tRNA-specific EM Novoa, O Vargas-Rodriguez, S Lange, Y Goto, H Suga, ... Journal of Biological Chemistry 290 (16), 10495-10503, 2015 | 25 | 2015 |
Engineered aminoacyl-tRNA synthetases with improved selectivity toward noncanonical amino acids HS Kwok, O Vargas-Rodriguez, SV Melnikov, D Söll ACS chemical biology 14 (4), 603-612, 2019 | 24 | 2019 |
Conformational and chemical selection by a trans-acting editing domain EM Danhart, M Bakhtina, WA Cantara, AB Kuzmishin, X Ma, BL Sanford, ... Proceedings of the National Academy of Sciences 114 (33), E6774-E6783, 2017 | 22 | 2017 |
A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation KS Hoffman*, O Vargas-Rodriguez*, DW Bak, T Mukai, LK Woodward, ... Journal of Biological Chemistry 294 (34), 12855-12865, 2019 | 17 | 2019 |
Plasticity and constraints of tRNA aminoacylation define directed evolution of aminoacyl-tRNA synthetases A Crnković, O Vargas-Rodriguez, D Söll International journal of molecular sciences 20 (9), 2294, 2019 | 16 | 2019 |
Effects of heterologous tRNA modifications on the production of proteins containing noncanonical amino acids A Crnković*, O Vargas-Rodriguez*, A Merkuryev, D Söll Bioengineering 5 (1), 11, 2018 | 16 | 2018 |
Bacterial translation machinery for deliberate mistranslation of the genetic code O Vargas-Rodriguez, AH Badran, KS Hoffman, M Chen, A Crnković, ... Proceedings of the National Academy of Sciences 118 (35), e2110797118, 2021 | 14 | 2021 |
Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity O Vargas-Rodriguez, M Bakhtina, D McGowan, J Abid, Y Goto, H Suga, ... Journal of Biological Chemistry 295 (48), 16180-16190, 2020 | 12 | 2020 |
Uncovering translation roadblocks during the development of a synthetic tRNA A Prabhakar, N Krahn, J Zhang, O Vargas-Rodriguez, M Krupkin, Z Fu, ... Nucleic Acids Research 50 (18), 10201-10211, 2022 | 11 | 2022 |