| TLR3 deficiency in patients with herpes simplex encephalitis SY Zhang, E Jouanguy, S Ugolini, A Smahi, G Elain, P Romero, D Segal, ... science 317 (5844), 1522-1527, 2007 | 1290 | 2007 |
| Structural basis of toll-like receptor 3 signaling with double-stranded RNA L Liu, I Botos, Y Wang, JN Leonard, J Shiloach, DM Segal, DR Davies Science 320 (5874), 379-381, 2008 | 896 | 2008 |
| Therapeutic applications of extracellular vesicles: clinical promise and open questions B György, ME Hung, XO Breakefield, JN Leonard Annual review of pharmacology and toxicology 55 (1), 439-464, 2015 | 529 | 2015 |
| The TLR3 signaling complex forms by cooperative receptor dimerization JN Leonard, R Ghirlando, J Askins, JK Bell, DH Margulies, DR Davies, ... Proceedings of the National Academy of Sciences 105 (1), 258-263, 2008 | 338 | 2008 |
| Stabilization of exosome-targeting peptides via engineered glycosylation ME Hung, JN Leonard Journal of Biological Chemistry 290 (13), 8166-8172, 2015 | 309 | 2015 |
| FedExosomes: engineering therapeutic biological nanoparticles that truly deliver ME Marcus, JN Leonard Pharmaceuticals 6 (5), 659-680, 2013 | 245 | 2013 |
| TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection I Jelinek, JN Leonard, GE Price, KN Brown, A Meyer-Manlapat, ... The Journal of Immunology 186 (4), 2422-2429, 2011 | 230 | 2011 |
| A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery ME Hung, JN Leonard Journal of extracellular vesicles 5 (1), 31027, 2016 | 215 | 2016 |
| Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis C Ricci, V Pastukh, J Leonard, J Turrens, G Wilson, D Schaffer, ... American Journal of Physiology-Cell Physiology 294 (2), C413-C422, 2008 | 188 | 2008 |
| Modular extracellular sensor architecture for engineering mammalian cell-based devices NM Daringer, RM Dudek, KA Schwarz, JN Leonard ACS synthetic biology 3 (12), 892-902, 2014 | 151 | 2014 |
| Rewiring human cellular input–output using modular extracellular sensors KA Schwarz, NM Daringer, TB Dolberg, JN Leonard Nature chemical biology 13 (2), 202-209, 2017 | 143 | 2017 |
| Antiviral RNAi therapy: emerging approaches for hitting a moving target JN Leonard, DV Schaffer Gene therapy 13 (6), 532-540, 2006 | 143 | 2006 |
| Lentivirus delivery of IL‐10 to promote and sustain macrophage polarization towards an anti‐inflammatory phenotype RM Boehler, R Kuo, S Shin, AG Goodman, MA Pilecki, JN Leonard, ... Biotechnology and bioengineering 111 (6), 1210-1221, 2014 | 133 | 2014 |
| Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets JMH Liu, J Zhang, X Zhang, KA Hlavaty, CF Ricci, JN Leonard, LD Shea, ... Biomaterials 80, 11-19, 2016 | 119 | 2016 |
| Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression RM Gower, RM Boehler, SM Azarin, CF Ricci, JN Leonard, LD Shea Biomaterials 35 (6), 2024-2031, 2014 | 89 | 2014 |
| Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape JN Leonard, DV Schaffer Journal of Virology 79 (3), 1645-1654, 2005 | 80 | 2005 |
| Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli Y Chuang, ME Hung, BK Cangelose, JN Leonard Innate immunity 22 (8), 647-657, 2016 | 77 | 2016 |
| The COMET toolkit for composing customizable genetic programs in mammalian cells PS Donahue, JW Draut, JJ Muldoon, HI Edelstein, N Bagheri, JN Leonard Nature communications 11 (1), 779, 2020 | 68 | 2020 |
| The evolution of synthetic receptor systems J Manhas, HI Edelstein, JN Leonard, L Morsut Nature chemical biology 18 (3), 244-255, 2022 | 62 | 2022 |
| Computation-guided optimization of split protein systems TB Dolberg, AT Meger, JD Boucher, WK Corcoran, EE Schauer, ... Nature chemical biology 17 (5), 531-539, 2021 | 62 | 2021 |
David SchafferProfessor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience, UC Berkeley在 berkeley.edu 的电子邮件经过验证
