| Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet JA Piccirilli, SA Benner, T Krauch, SE Moroney, SA Benner Nature 343 (6253), 33-37, 1990 | 870 | 1990 |
| Metal ion catalysis in the Tetrahymena ribozyme reaction JA Piccirilli, JS Vyle, MH Caruthers, TR Cech Nature 361 (6407), 85-88, 1993 | 511 | 1993 |
| Hachimoji DNA and RNA: A genetic system with eight building blocks S Hoshika, NA Leal, MJ Kim, MS Kim, NB Karalkar, HJ Kim, AM Bates, ... Science 363 (6429), 884-887, 2019 | 439 | 2019 |
| RNA catalyses nuclear pre-mRNA splicing SM Fica, N Tuttle, T Novak, NS Li, J Lu, P Koodathingal, Q Dai, JP Staley, ... Nature 503 (7475), 229-234, 2013 | 418 | 2013 |
| A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore H Huang, NB Suslov, NS Li, SA Shelke, ME Evans, Y Koldobskaya, ... Nature chemical biology 10 (8), 686-691, 2014 | 351 | 2014 |
| Ribozyme-catalyzed and nonenzymic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom D Herschlag, JA Piccirilli, TR Cech Biochemistry 30 (20), 4844-4854, 1991 | 330 | 1991 |
| Aminoacyl esterase activity of the Tetrahymena ribozyme JA Piccirilli, TS McConnell, AJ Zaug, HF Noller, TR Cech Science 256 (5062), 1420-1424, 1992 | 290 | 1992 |
| General acid catalysis by the hepatitis delta virus ribozyme SR Das, JA Piccirilli Nature Chemical Biology 1 (1), 45-52, 2005 | 284 | 2005 |
| Metal ion catalysis during splicing of premessenger RNA EJ Sontheimer, S Sun, JA Piccirilli Nature 388 (6644), 801-805, 1997 | 246 | 1997 |
| Three metal ions at the active site of the Tetrahymena group I ribozyme S Shan, A Yoshida, S Sun, JA Piccirilli, D Herschlag Proceedings of the National Academy of Sciences 96 (22), 12299-12304, 1999 | 222 | 1999 |
| Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns. PM Gordon, EJ Sontheimer, JA Piccirilli Rna 6 (2), 199-205, 2000 | 193 | 2000 |
| RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme Z Miao, RW Adamiak, M Antczak, RT Batey, AJ Becka, M Biesiada, ... Rna 23 (5), 655-672, 2017 | 186 | 2017 |
| Defining the Catalytic Metal Ion Interactions in the Tetrahymena Ribozyme Reaction S Shan, AV Kravchuk, JA Piccirilli, D Herschlag Biochemistry 40 (17), 5161-5171, 2001 | 183 | 2001 |
| Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome EJ Sontheimer, PM Gordon, JA Piccirilli Genes & development 13 (13), 1729-1741, 1999 | 176 | 1999 |
| Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage NS Li, JK Frederiksen, JA Piccirilli Accounts of chemical research 44 (12), 1257-1269, 2011 | 172 | 2011 |
| RNA catalysis by a group I ribozyme: developing a model for transition state stabilization TR Cech, D Herschlag, JA Piccirilli, AM Pyle The Journal of biological chemistry (Print) 267 (25), 17479-17482, 1992 | 164 | 1992 |
| Synthetic antibodies for specific recognition and crystallization of structured RNA JD Ye, V Tereshko, JK Frederiksen, A Koide, FA Fellouse, SS Sidhu, ... Proceedings of the National Academy of Sciences 105 (1), 82-87, 2008 | 152 | 2008 |
| Crystal structure of the catalytic core of an RNA-polymerase ribozyme DM Shechner, RA Grant, SC Bagby, Y Koldobskaya, JA Piccirilli, ... Science 326 (5957), 1271-1275, 2009 | 143 | 2009 |
| Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center H Ramu, N Vázquez-Laslop, D Klepacki, Q Dai, J Piccirilli, R Micura, ... Molecular cell 41 (3), 321-330, 2011 | 141 | 2011 |
| Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis PM Gordon, JA Piccirilli Nature structural biology 8 (10), 893-898, 2001 | 140 | 2001 |
