| Predicting protein–protein interactions based only on sequences information J Shen, J Zhang, X Luo, W Zhu, K Yu, K Chen, Y Li, H Jiang Proceedings of the National Academy of Sciences 104 (11), 4337-4341, 2007 | 1115 | 2007 |
| Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition S Shangary, D Qin, D McEachern, M Liu, RS Miller, S Qiu, ... Proceedings of the National Academy of Sciences 105 (10), 3933-3938, 2008 | 816 | 2008 |
| Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation D Zhang, Y Wang, Z Shi, J Liu, P Sun, X Hou, J Zhang, S Zhao, BP Zhou, ... Cell reports 10 (8), 1335-1348, 2015 | 320 | 2015 |
| Ras conformational ensembles, allostery, and signaling S Lu, H Jang, S Muratcioglu, A Gursoy, O Keskin, R Nussinov, J Zhang Chemical reviews 116 (11), 6607-6665, 2016 | 319 | 2016 |
| Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells X Qiu, X Zhu, L Zhang, Y Mao, J Zhang, P Hao, G Li, P Lv, Z Li, X Sun, ... Cancer research 63 (19), 6488-6495, 2003 | 281 | 2003 |
| Structural basis for activity regulation of MLL family methyltransferases Y Li, J Han, Y Zhang, F Cao, Z Liu, S Li, J Wu, C Hu, Y Wang, J Shuai, ... Nature 530 (7591), 447-452, 2016 | 233 | 2016 |
| Identification of a cellularly active SIRT6 allosteric activator Z Huang, J Zhao, W Deng, Y Chen, J Shang, K Song, L Zhang, C Wang, ... Nature chemical biology 14 (12), 1118-1126, 2018 | 217 | 2018 |
| SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane J Huang, J Yan, J Zhang, S Zhu, Y Wang, T Shi, C Zhu, C Chen, X Liu, ... Nature communications 3 (1), 911, 2012 | 212 | 2012 |
| The structural basis of oncogenic mutations G12, G13 and Q61 in small GTPase K-Ras4B S Lu, H Jang, R Nussinov, J Zhang Scientific reports 6 (1), 21949, 2016 | 205 | 2016 |
| ASD: a comprehensive database of allosteric proteins and modulators Z Huang, L Zhu, Y Cao, G Wu, X Liu, Y Chen, Q Wang, T Shi, Y Zhao, ... Nucleic acids research 39 (suppl_1), D663-D669, 2011 | 190 | 2011 |
| Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view S Lu, H Jang, S Gu, J Zhang, R Nussinov Chemical Society Reviews 45 (18), 4929-4952, 2016 | 183 | 2016 |
| Allosite: a method for predicting allosteric sites W Huang, S Lu, Z Huang, X Liu, L Mou, Y Luo, Y Zhao, Y Liu, Z Chen, ... Bioinformatics 29 (18), 2357-2359, 2013 | 173 | 2013 |
| Crystal structure of HAb18G/CD147 implications for immunoglobulin superfamily homophilic adhesion XL Yu, T Hu, JM Du, JP Ding, XM Yang, J Zhang, B Yang, X Shen, ... Journal of Biological Chemistry 283 (26), 18056-18065, 2008 | 160 | 2008 |
| Harnessing allostery: a novel approach to drug discovery S Lu, S Li, J Zhang Medicinal research reviews 34 (6), 1242-1285, 2014 | 156 | 2014 |
| Allosteric methods and their applications: Facilitating the discovery of allosteric drugs and the investigation of allosteric mechanisms S Lu, Q Shen, J Zhang Accounts of chemical research 52 (2), 492-500, 2019 | 140 | 2019 |
| Allosteric modulator discovery: from serendipity to structure-based design S Lu, X He, D Ni, J Zhang Journal of medicinal chemistry 62 (14), 6405-6421, 2019 | 139 | 2019 |
| Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections Z Qin, J Zhang, B Xu, L Chen, Y Wu, X Yang, X Shen, S Molin, A Danchin, ... BMC microbiology 6, 1-18, 2006 | 137 | 2006 |
| Small molecule allosteric modulators of G-protein-coupled receptors: drug–target interactions S Lu, J Zhang Journal of medicinal chemistry 62 (1), 24-45, 2018 | 136 | 2018 |
| ADME evaluation in drug discovery. 9. Prediction of oral bioavailability in humans based on molecular properties and structural fingerprints S Tian, Y Li, J Wang, J Zhang, T Hou Molecular pharmaceutics 8 (3), 841-851, 2011 | 136 | 2011 |
| Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design S Lu, X He, Z Yang, Z Chai, S Zhou, J Wang, AU Rehman, D Ni, J Pu, ... Nature Communications 12 (1), 4721, 2021 | 134 | 2021 |
Duan NiThe University of Sydney在 sydney.edu.au 的电子邮件经过验证
